Navigation Links
New compound prevents alcoholic behavior, relapse in animals by blocking stress response

A study of alcohol-dependent animals shows that a newly discovered compound that blocks chemical signals active during the brain’s response to stress effectively stops excessive drinking and prevents relapse.

The new, synthetic compound, known as MTIP, also muted the anxiety that typically develops in rats experiencing the equivalent of a hangover. Such stress is linked with higher levels of a brain chemical called corticotropin-releasing factor (CRF), which is also thought to trigger relapse in rats that have developed a long-term dependency on alcohol. The research, by Markus Heilig, MD, PhD, at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and his team, appears in the March 7 issue of The Journal of Neuroscience.

"This study shows the activity of a compound that potentially could be used in human subjects," says George Koob, PhD, of the Scripps Research Institute. "It moves the field over another translational barrier, closer to the day when the dark side of addiction is treated."

The new findings build on previous work showing the effectiveness of blocking certain CRF receptors—proteins that bind CRF and make it active—in treating alcohol dependence in animals. CRF levels in the brain rise in the short term after drinking; in subjects that are not dependent, this activation returns to normal within a day or so. The new study shows that the CRF system becomes overactive in the long term in animals with a history of alcohol dependence, increasing the risk for relapse.

Heilig and his team showed that MTIP blocked the activity of CRF in stressful situations without affecting its activity under ordinary circumstances. They studied rats that had been put through several cycles of heavy alcohol consumption and withdrawal to create dependency, as well as animals selectively bred to consume more alcohol. Injections of MTIP prevented excessive drinking of alcohol in both cases and eliminated the rats?suscept
'"/>

Source:Society for Neuroscience


Page: 1 2

Related biology news :

1. Researchers discover chemical compounds that affect plant growth
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
5. Novel compounds show promise as safer, more potent insecticides
6. Metal-containing compounds show promise as HIV weapon
7. Natural compound from pond scum shows potential activity against Alzheimers
8. Chemical compound inhibits tumor growth, size in new mouse study
9. Seaweed yields new compounds with pharmaceutical potential
10. Phenolic compounds may explain Mediterranean diet benefits
11. UC Berkeley researchers create a biologically-inspired artificial compound eye
Post Your Comments:
(Date:8/21/2014)... Carolina State University have developed a novel and versatile ... applications for creating new materials as well as for ... technique allows us to model much larger and more ... quickly," says Nan Li, lead author of a paper ... State,s Department of Materials Science and Engineering. "This is ...
(Date:8/20/2014)... Institute (HCI) at the University of Utah have identified ... BCR-ABL, the unregulated enzyme driving the blood cancer chronic ... nearly 6,000 new cases of CML will be diagnosed ... kinase inhibitors (TKIs), target BCR-ABL and are effective at ... control it in a way that allows patients to ...
(Date:8/20/2014)... visible in in this image of the Para and ... were most likely intentionally set in order to deforest ... or stand of trees where the land is thereafter ... conversion of forestland to farms, ranches, or urban use. ... of the Amazon Rainforest in the middle of the ...
Breaking Biology News(10 mins):Researchers develop models to study polyelectrolytes, including DNA and RNA 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... serious and growing environmental problem, especially on the Indian ... years ago, used genetic techniques to create "arsenic-eating" plants ... was a problem, however. The arsenic sequestered from soil ... it difficult to harvest for safe disposal. Now, the ...
... from the University of Montana, University of California - ... have shown that a top predator strongly affected plants ... web by eating organisms that transport nutrients between ecosystems. ... by thwarting nutrient subsidies," is published in the February ...
... Antiretroviral therapy (ART) for infants born with HIV infection ... five months of life, according to a study published ... Infectious Diseases, now available online. , Uncertainty over when ... from their mothers revolves around balancing the benefits of ...
Cached Biology News:Researchers discover way to transport environmental arsenic to plant leaves in new clean-up strategy 2Not just the birds 2Not just the birds 3New study shows benefit of early therapy in HIV-infected infants 2
(Date:8/21/2014)... & Rockville, MD (PRWEB) August 21, 2014 ... (ITI) is making progress in its development of JRC-LAMP-vax, ... Japanese red cedar pollen. Phase IC studies began this ... real solution to hay fever. , The Japanese red ... 35 million people in Japan. Mountain Cedar pollen wreaks ...
(Date:8/21/2014)... team including DESY scientists has observed tiny quantum vortices ... in the journal Science that the exotic ... nanodroplets. It is the first time that the quantum ... of what is known as superfluid helium, have been ... expectations," says Andrey Vilesov of the University of Southern ...
(Date:8/21/2014)... Ireland , August 21, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/3zh3q8/global_hormone ) has announced the addition ... 2014-2018"  report to their offering.  ... known as hormone therapy, is a means ... being produced by the body. This type ...
(Date:8/21/2014)... 21, 2014 Telomere Biosciences, LLC (Telomere ... "TELO-20 for Dogs" with Telomerase Activation Complex ... the world for dogs. Telomeres are the protective ... the body. A wealth of ground-breaking research by ... Science and Aging, including Nobel laureates, has demonstrated ...
Breaking Biology Technology:Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4Scientists observe quantum vortices in cold helium droplets 2Global Hormone Replacement Therapy Market 2014-2018: Key Vendors are Actavis, Bayer, Merck & Co, Novartis and Novo Nordisk 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3
... the past month, I've seen a half dozen great ... technology market. The products vary widely from unique hardware ... mobile services and beyond. Each concept is carefully conceived ... and each product meets a real and unfulfilled need ...
... At a meeting Monday highlighting university-business partnerships in Wisconsin, ... company based in Hartland, Wis., demonstrated its latest tool ... secretary of commerce for the U.S. Patent and ... R-Wis. The nations highest ranking patent official also met ...
... about asking whether technology drives business or business drives technology. ... Silence all the rattling about how superior this technology is ... certain questions that if you have to ask, you probably ... more satisfying line of inquiry is how much of your ...
Cached Biology Technology:Where have all the angels gone? 2Where have all the angels gone? 3Where have all the angels gone? 4Sensenbrenner and USPTO Director highlight benefits of technology transfer 2Sensenbrenner and USPTO Director highlight benefits of technology transfer 3Technology as the engine of business innovation 2Technology as the engine of business innovation 3
...
...
Mouse polyclonal antibody to TNPO2 - transportin 2 (importin 3, karyopherin beta 2b)...
Mouse monoclonal antibody to CDC2L5 - cell division cycle 2-like 5 (cholinesterase-related cell division controller)...
Biology Products: