Navigation Links
New component of the 'brakes' on nerve regeneration found

chinery within neurons. Also, they found that treating neurons with a nonfunctional version of TAJ/TROY abolished neurons' response to the "braking" molecules produced by myelin and encouraged neuron growth.

"Given the limited expression of p75, the discovery of TAJ function is an important step for understanding the regulation of axon regeneration," wrote Mi and colleagues.

Wrote Park and colleagues, "The implication that more than one TNF receptor member may be involved in myelin inhibition adds a new level of complexity to designing therapeutic strategies for treating CNS injury." They cited studies showing that TNF receptors are expressed in many types of cells in the CNS and are intimately involved in inflammatory responses that also play a role--perhaps harmful, perhaps beneficial to regeneration or recovery--in regulating response to injury. "Further characterization of the underlying mechanisms of these findings and their relation to myelin inhibition may provide important insights into designing therapeutic strategies to block myelin inhibition and cell death in the context of CNS injury," they wrote.

###

Jong Bae Park, Glenn Yiu, Shinjiro Kaneko, Jing Wang, Jufang Chang, and Zhigang He: "A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors"

Zhaohui Shao, Jeffrey L. Browning, Xinhua Lee, Martin L. Scott, Sveltlana Shulga-Morskaya, Norm Allaire, Greg Thill, Melissa Levesque, Dinah Sah, John M. McCoy, Beth Murray, Vincent Jung, R. Blake Pepinsky, and Sha Mi: "TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration"


'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Gap-climbing fruit flies reveal components of goal-driven behaviors
2. Study uncovers dirty little secret: Soil emissions are much-bigger-than-expected component of air pollution
3. Solexa and collaborating scientists illuminate the small RNA component of the transcriptome
4. Uniquely human component of language found in gregarious birds
5. Mice lacking key immune component still control chronic viral infections
6. African parasite makes component of fat differently from all other organisms
7. New study reveals components of cocoa may enhance the appearance of the skin
8. Researchers in Montréal and the US create model of key immune-system component
9. Twin studies reveal genetic components leading to cardiac and kidney disease
10. Wisconsin scientists grow critical nerve cells
11. Clam embryo study shows pollutant mixture adversely affects nerve cell development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New component the brakes nerve regeneration found

(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/st5b3m/saudi_arabia ) has announced the ... - Growth, Trends & Forecasts (2014-2020)" report to ... Sensors market is estimated at $0.23 billion by 2018 ... The near future will bring biomedical sensors ... individual. These sensors can be set to trigger alerts ...
(Date:8/24/2015)... , August 24, 2015 The ... ,s largest biometrics manufacturer DERMALOG and its customized solutions ... "2015 African Biometrics Company of the Year Award". DERMALOG is ... Nigeria .   -Cross reference: Picture is ... - On Thursday evening, in ...
(Date:8/20/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... Card Alliance and the EMV Migration Forum.  ... Card Alliance Latin America (SCALA) Chapter provides NXT-ID, Inc. ... leaders promoting adoption of smart card technology. ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 2NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 3NXT-ID, Inc. Joins Smart Card Alliance and EMV Migration Forum 4
... in Spanish . , New World hemorrhagic ... that can cause terrible, Ebola-like symptoms. Current treatments are ... Hughes Medical Institute (HHMI) researchers have discovered exactly how ... onto and infects human cells, offering a much-needed lead ...
... built a sensor array that, for the first time, can ... living cell. Hydrogen peroxide has long been known to ... evidence that points to a more beneficial role: it appears ... pathway that stimulates growth, among other functions. When that ...
... better prevent diseases may be in our future, just ... University recently published an academic journal article discussing the ... of food on gene expression. The researchers discussed the ... from expressing disease. The researchers said nutrigenomics could completely ...
Cached Biology News:New ways to disarm deadly South American hemorrhagic fever viruses 2New ways to disarm deadly South American hemorrhagic fever viruses 3New sensor array detects single molecules for the first time 2Studies on nutrients, gene expression could lead to tailored diets for disease prevention 2Studies on nutrients, gene expression could lead to tailored diets for disease prevention 3
(Date:9/1/2015)... ... September 01, 2015 , ... A new host-based therapy ... at the Keck Graduate Institute and its collaborators. The discovery has the potential ... published online on August 27 by Scientific Reports, an open access research journal ...
(Date:9/1/2015)... , September 1, 2015 Shire plc ... Sara Mathew to its Board of Directors as ... the Audit, Compliance & Risk Committee of the Shire Board. ... Sara previously served as Chairman, President and Chief ... December 2013. During her 12-year tenure at D&B, she helped ...
(Date:8/31/2015)... ... , ... In recent years, biodegradable plastics have found wide ... and compostability. These properties can help in limiting the degradation of the enviorment ... the market for biodegradable plastics can be broadly segmented into packaging, fibers, agriculture, ...
(Date:8/31/2015)... DUBLIN , Aug. 31, 2015 Research ... of the "Mexico Biomedical Sensors Market - Growth, ... The Mexico Biomedical Sensors market ... CAGR of 2.68% over the period 2014-2020 ... adaptable to the genetic formulation of each individual. These ...
Breaking Biology Technology:Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 2Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 3Scientists Discover New Use for an Old Therapy Inhibiting Deadly Pathogens Including Ebola and Anthrax 4Shire Appoints Sara Mathew to Board of Directors 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Mexico Biomedical Sensors Market Report 2015-2020 2
... having the next big thing is not enough. , ... mid-sized firm occupying several hard-won niches, or a high-energy ... says Tom Miller, an intellectual property lawyer with Michael ... presentation to eInnovate, a Milwaukee-based technology forum, Miller said ...
... , a niche hardware company that makes networking products for ... Chippewa Valley Angel Investors Network . , ,"This [investment] is ... getting our products to market sooner," said Corky Seeber, president ... space and equipment, and to develop additional products." , ,"Were ...
... thousands of manufacturing jobs that have vanished all through ... industries is a fool's errand. Instead, efforts are underway ... the technological inventions coming out of Wisconsin's institutes of ... entities have sprung up with the intent of assisting ...
Cached Biology Technology:Protect your intellectual property before it's too late 2Protect your intellectual property before it's too late 3Chippewa Valley angels invest in network hardware company 2Chippewa Valley angels invest in network hardware company 3Will tech transfer save Wisconsin's economy? 2Will tech transfer save Wisconsin's economy? 3Will tech transfer save Wisconsin's economy? 4Will tech transfer save Wisconsin's economy? 5Will tech transfer save Wisconsin's economy? 6Will tech transfer save Wisconsin's economy? 7Will tech transfer save Wisconsin's economy? 8
...
Contains L-glutamine...
Immunogen: MBP-fusion protein of the C-terminal region of the a2 subunit (amino acids K581-D670) Storage: -20 C, Avoid Freeze/Thaw Cycles...
... This antibody recognizes murine IRF7 ... with other related IRF proteins. ... murine IRF7 protein was confirmed ... the 293T cells transfected with ...
Biology Products: