Navigation Links
New component of the 'brakes' on nerve regeneration found

Among the principal obstacles to regenerating spinal cord and brain cells after injury is the "braking" machinery in neurons that prevents regeneration. While peripheral nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brakes firmly in place and locked.

Now, two groups of scientists have independently found a new component of that braking machinery, adding to understanding of the regulation of neuronal regeneration and of possible treatments to switch off the brakes on regrowth of spinal cord or brain tissue.

The two groups--one group led by Jong Bae Park, Glenn Yiu, and colleagues from Children's Hospital Boston and the other led by Sha Mi and colleagues of Biogen Idec, Inc.--discovered that a protein variously called TAJ or TROY acts as an important part of the receptor on neurons that responds to growth-inhibitory molecules in myelin. Specifically, these molecules prevent the growth of the cablelike axons of injured neurons. Myelin is the fatty sheath that encases neurons and acts as an insulator and aid to the transmission of nerve impulses.

Researchers knew that CNS neurons had receptors on their surface that accepted the inhibitory molecules--like a key fitting a lock--and switched-on inhibitory signaling within the neuron. They had also shown that a protein called p75 could function as a component of the complex of proteins that make up this receptor. The puzzle, however, was that p75 is not widely made in the adult neurons in which this inhibitory receptor complex is known to function.

The two research groups turned their attention to TAJ/TROY because it is a member of the same family of receptor proteins--called TNF receptors--as p75. Their experiments revealed that TAJ/TROY is produced throughout the adult brains of mice. Also, they found that TAJ/TROY readily fits into the inhibitory receptor complex and that the resulting receptor complex switches-on the inhibitory ma
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Gap-climbing fruit flies reveal components of goal-driven behaviors
2. Study uncovers dirty little secret: Soil emissions are much-bigger-than-expected component of air pollution
3. Solexa and collaborating scientists illuminate the small RNA component of the transcriptome
4. Uniquely human component of language found in gregarious birds
5. Mice lacking key immune component still control chronic viral infections
6. African parasite makes component of fat differently from all other organisms
7. New study reveals components of cocoa may enhance the appearance of the skin
8. Researchers in Montréal and the US create model of key immune-system component
9. Twin studies reveal genetic components leading to cardiac and kidney disease
10. Wisconsin scientists grow critical nerve cells
11. Clam embryo study shows pollutant mixture adversely affects nerve cell development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New component the brakes nerve regeneration found

(Date:8/27/2014)... A growing number of studies have shown ... the pathogenesis of Parkinson,s disease. Previous studies ... Medical University in China have shown that ... injury, reduced divalent metal transporter 1 expression, ... substantia nigra of rotenone-induced Parkinson,s disease rats. ...
(Date:8/27/2014)... hours ago the Happy Camp Complex of fires had ... July complex had consumed 35,530 as of eight hours ... the Happy Camp Ranger District of the Klamath National ... August 11, 2014. All but three of those fires ... list of contained fires and their size at containment: ...
(Date:8/27/2014)... State University have found that century-old museum specimens hold clues ... pest that can weaken and kill trees and the ... insect populations increase on oak and maple trees in warmer ... also increase with global warming," says Dr. Elsa Youngsteadt, a ... paper on the work. , "More scale insects would be ...
Breaking Biology News(10 mins):Happy Camp and July Fire Complexes in California 2Museum specimens, modern cities show how an insect pest will respond to climate change 2
... National Institute of General Medical Sciences (NIGMS), part of ... million for grants in scientific areas it identified as ... to stimulate biomedical research and the economy using funds ... Act). "The GO grants fund projects that promise ...
... release is available in German . , ... instrument wouldn,t be a bad thing. It could help to ... measure. However, it must do so constructively. In order to ... just imagination, physicists at the Max Planck Institute for Astrophysics ...
... scientists have succeeded in producing the polymers used for ... of fossil fuel based chemicals. This groundbreaking research, which ... plastics, is published in two papers in the journal ... 50th anniversary. Polymers are molecules found in ...
Cached Biology News:NIGMS invests in scientific Grand Opportunities with Recovery Act funds 2NIGMS invests in scientific Grand Opportunities with Recovery Act funds 3Visual assistance for cosmic blind spots 2Visual assistance for cosmic blind spots 3Visual assistance for cosmic blind spots 4Bioengineers succeed in producing plastic without the use of fossil fuels 2
(Date:8/27/2014)... Flagship Biosciences LLC, a leading provider of ... medical device industries, has announced a laboratory and office ... consolidated its histology and tissue analysis operations from separate ... north of Denver. The new addresses are: , ... 100, Westminster, CO 80021 , Tissue Image Analysis Lab, ...
(Date:8/27/2014)... , Aug. 27, 2014 Research and ... Stable Isotope Ratio Mass Spectrometer Industry Report 2014" ... Stable Isotope Ratio Mass Spectrometer Industry Report 2014 is ... of the global isotope ratio mass spectrometer industry. ... industry including definitions, classifications, applications and industry chain structure. ...
(Date:8/27/2014)... Tris Pharma, a specialty pharmaceutical company focused ... it has been selected as an award winner in ... Awards for Excellence competition in the Business Expansion ... judges from SCORE (Counselors to America,s Small Business) and ... at a gala event to be held on October ...
(Date:8/27/2014)... Boca Raton, FL (PRWEB) August 27, 2014 ... that are applied through the use of a handheld ... consumers across the United States. , The brand ... care unit. BIOEQUA researchers were surprised to learn that ... to be made extremely small and delivered directly to ...
Breaking Biology Technology:Flagship Biosciences Announces Relocation and Expansion 2Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2
... to bring about a consolidated manufacturing management platform, ... agreement to buy Datasweep, Inc. , a ... of the transaction, were not disclosed. , ,Located ... customers in the pharmaceutical, high-tech electronics, automotive and ...
... Paragon Development Systems (PDS) is ... integrated solution for medium-sized organizations seeking information ... businesses to integrate communications, create shared environments, ... consolidate storage and servers, providing greater freedom ...
... Two UW-Madison computer science professors, Paul ... named to the National LambdaRails Networking Researching Council (NNRC), ... fiber optic networks research goals. , ,The National ... across the country, which over the past three years ...
Cached Biology Technology:Two UW-Madison professors named to National LambdaRail Networking Research Council 2
... pulsed field separations of DNA larger than 2, ... megabase pairs. This agarose has the highest gel strength of any ... ... ...
Liquid. PBS containing 10 mM NaN 3 . AVOID FREEZE/THAW CYCLES. Recognizes α1, 2, 3, 5, 6 and 7 subunits of 20S proteasome. ...
Mouse monoclonal antibody to Lats2....
... Membrane Protein 2, Synaptobrevin 2). ... homology with any other known ... expected that the antibody will ... multata and bovine due to ...
Biology Products: