Navigation Links
New component of the 'brakes' on nerve regeneration found

Among the principal obstacles to regenerating spinal cord and brain cells after injury is the "braking" machinery in neurons that prevents regeneration. While peripheral nerves have no such machinery and can readily regenerate, central nervous system (CNS) neurons have their brakes firmly in place and locked.

Now, two groups of scientists have independently found a new component of that braking machinery, adding to understanding of the regulation of neuronal regeneration and of possible treatments to switch off the brakes on regrowth of spinal cord or brain tissue.

The two groups--one group led by Jong Bae Park, Glenn Yiu, and colleagues from Children's Hospital Boston and the other led by Sha Mi and colleagues of Biogen Idec, Inc.--discovered that a protein variously called TAJ or TROY acts as an important part of the receptor on neurons that responds to growth-inhibitory molecules in myelin. Specifically, these molecules prevent the growth of the cablelike axons of injured neurons. Myelin is the fatty sheath that encases neurons and acts as an insulator and aid to the transmission of nerve impulses.

Researchers knew that CNS neurons had receptors on their surface that accepted the inhibitory molecules--like a key fitting a lock--and switched-on inhibitory signaling within the neuron. They had also shown that a protein called p75 could function as a component of the complex of proteins that make up this receptor. The puzzle, however, was that p75 is not widely made in the adult neurons in which this inhibitory receptor complex is known to function.

The two research groups turned their attention to TAJ/TROY because it is a member of the same family of receptor proteins--called TNF receptors--as p75. Their experiments revealed that TAJ/TROY is produced throughout the adult brains of mice. Also, they found that TAJ/TROY readily fits into the inhibitory receptor complex and that the resulting receptor complex switches-on the inhibitory ma
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Gap-climbing fruit flies reveal components of goal-driven behaviors
2. Study uncovers dirty little secret: Soil emissions are much-bigger-than-expected component of air pollution
3. Solexa and collaborating scientists illuminate the small RNA component of the transcriptome
4. Uniquely human component of language found in gregarious birds
5. Mice lacking key immune component still control chronic viral infections
6. African parasite makes component of fat differently from all other organisms
7. New study reveals components of cocoa may enhance the appearance of the skin
8. Researchers in Montréal and the US create model of key immune-system component
9. Twin studies reveal genetic components leading to cardiac and kidney disease
10. Wisconsin scientists grow critical nerve cells
11. Clam embryo study shows pollutant mixture adversely affects nerve cell development
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New component the brakes nerve regeneration found

(Date:9/16/2014)... morbidity amongst women in Australia is increased by ... today (17 September) in BJOG: An International ... generally enjoy high standards of living; however, existing ... particular between indigenous and non indigenous Australians. , ... impact of socioeconomic position on severe maternal morbidities ...
(Date:9/16/2014)... $100 trillion in cumulative public and private spending, ... 40 percent reduction of urban passenger transport emissionscould ... public transportation, walking and cycling in cities, according ... of California, Davis, and the Institute for Transportation ... estimated 1.4 million early deaths could be avoided ...
(Date:9/16/2014)... September 13, 2014. The fire is human-caused and ... acres in size and is mostly being fueled by ... Monday night due to higher humidity. Yesterday (8/15), ... to construct a fireline on the West and North sides ... the fire: , 7 20-person Crews, 4 Hot Shot Crews, ...
Breaking Biology News(10 mins):New study examines the impact of socioeconomic position & maternal morbidity in Australia 2New study examines the impact of socioeconomic position & maternal morbidity in Australia 3Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 2Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 3Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 4Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 5
... researcher, Dr. Mark Flynn,s high-speed flywheel motor controller is ... the world. Flynn,s design has been incorporated into energy ... and sold by VYCON Inc. The 8,000 RTG ... significantly to port emissions and, as such, have ...
... an international group of colleagues to delay their race ... 7,000-hour slog through a compendium of 50,000 scientific articles ... that might herald the furtive presence of pancreatic cancer. ... and expensive testing that needs to be done before ...
... (ASM) will hold its 109th General Meeting May ... feature approximately 3,000 individual scientific presentations spanning the ... of 10,000. Microbiologists study living organisms and ... human and animal health, agriculture, the environment and ...
Cached Biology News:Saving energy and the environment with Flywheels 2Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection 2Compendium of pancreatic cancer biomarkers established as strategic approach to early-detection 3
(Date:9/16/2014)... Sept. 16, 2014  Biocom, the association representing the ... recognizes the 9 th Annual National Health Information ... IT technologies in improving our health care system. ... one of the world,s most vibrant hubs for health ... health applications to genomic testing to remote patient monitoring," ...
(Date:9/16/2014)... From cell phones to cars and flashlights, ... Scientists and technology companies constantly are seeking ways ... the first time using a water-based solution, researchers ... long-lasting and more efficient nuclear battery that could ... reliable energy source in automobiles and also in ...
(Date:9/16/2014)... BlueInGreen® , a water quality company ... dissolved gases into liquids, announced the addition of ... representative firm to its sales network. H2Flow will ... and wastewater applications in the Canadian provinces of ... 1992 and serves Quebec and Ontario markets for ...
(Date:9/16/2014)... Sept. 16, 2014  Donald Fresne, President and CEO of ... Stephan Vagner , PhD to its Scientific Advisory Committee. ... Toulouse, France , performed research at Embl (European ... at Inserm, the French institute of health and medical research. ... at the Curie Institute, Orsay, France , ...
Breaking Biology Technology:Biocom Recognizes National Health IT Week 2BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2New Appointment to the Scientific Advisory Committee at Egenix, Inc. 2
... announced today that its,Chief Financial Officer, Rick McCook, will ... July 2006., "I have enjoyed my work with ... my tenure," said McCook. "However, at this time I,intend ... to,more fully leverage my skills and experience.", "During ...
... 18 Osteotech, Inc.,(Nasdaq: OSTE ), a ... for,regenerative medicine, announced today that it has renewed ... Transplant Alliance,("EATA"), a Bulgarian public non-profit foundation. The ... an initial term of seven years and,automatically renews ...
... 18 ev3 Inc. (Nasdaq:,EVVV) will release its 2008 ... regular market trading hours., The company will host ... a.m. CT (8:30 a.m. ET). ev3 management will review ... a question and answer,session., The conference call will ...
Cached Biology Technology:Osteotech Renews Tissue Recovery Agreement with the Euro Atlantic Transplant Alliance 2Osteotech Renews Tissue Recovery Agreement with the Euro Atlantic Transplant Alliance 3
... identification Service includes 1. Scanning of ... 3. High-sensitive tryptic in-gel digestion and ... for MALDI-MS 5. Acquisition of PMF ... (Bruker ultraflex TOF/TOF) 6. Acquisition of ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... number is a new product number, ... number. If showing no availability yet, ... number (R4276) or contact customer service ... (expanded surface, easy grip) ...
... stored within neurons in vesicles called ... the synaptic bouton. Synaptosomes may ... from other cellular debris. Abnormalites in ... many pathological condtions. Conditions of ...
Biology Products: