Navigation Links
New clues to the dark side of a key anti-tumor guardian

Although researchers over recent years have established a foothold in understanding how p53 protects against cancer, the mechanisms by which it might contribute to aging and lifespan are not well studied. In work reported this week, researchers studying p53 function in fruit flies show new evidence that despite the protective role of p53 as a guardian against tumor formation, normal levels of p53 activity--at least in some cell types--may indeed contribute to aging and decreased lifespan.

The p53 protein is known to be a critical player in our body's natural defense against cancer--it is absent in many types of tumor cells--but it also represents an intriguing paradox when it comes to the broader roles this protein plays in our well being. Past work has shown that in animal models, hyperactivation of the p53 protein is beneficial in terms of bestowing extra protection against tumor formation, but at the same time it has a significant negative effect: a shortening of lifespan, accompanied by hallmarks of accelerated aging, including osteoporosis, decreased stress resistance, and organ atrophy.

The work is reported by Stephen Helfand and colleagues at Brown Universtiy, University of Connecticut Health Center, and University of Texas Southwest Medical Center.

The researchers investigated the role of p53 in aging by observing the effects of disrupting this protein in the neurons of adult fruit flies. They found that expression of a so-called "dominant-negative" version of p53--that is, a disfunctional version of the protein that inhibits the activity of normal p53--extended flies' life span and increased their ability to withstand gene-damaging stress. The authors found that this disruption of p53 did not further increase the lifespan of flies on a calorie-restricted diet, suggesting that decreased p53 activity and calorie restriction may influence lifespan through a common molecular mechanism.

Because neurons are less prone to tumor for mation than other cell types, and because disruption of p53 activity in neurons was sufficient to extend lifespan in the fruit fly, the new findings suggest that by attending to p53 activity in different cell types, it may be possible to take therapeutic advantage of p53's tumor-preventing activity while avoiding its unwanted negative effects on lifespan.


'"/>

Source:Cell Press


Related biology news :

1. Insight into DNAs weakest links may yield clues to cancer biology
2. High-powered gene profiles provide clues to genes involved in common form of lung cancer
3. Genetic links could unlock clues to leading cause of blindness
4. ORNL, UC Berkeley unravel real-world clues to Earths mysteries
5. Elderly mice yield clues to the process of growing old
6. Engineered skin offers clues to melanoma development
7. Scientists uncover new clues about brain function in human behavior
8. On a wing and a prayer - Alaska researchers seek clues to bird flu
9. Infection alarm yields clues to immune system behavior
10. Pair of studies offer new clues to combat antibiotic resistance
11. Ancient DNA provides clues to the evolution of social behavior
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... , March 30, 2017  On April 6-7, ... Hack the Genome hackathon at Microsoft,s headquarters ... two-day competition will focus on developing health and wellness ... Hack the Genome is the first ... tremendous. The world,s largest companies in the genomics, tech ...
(Date:3/29/2017)... March 29, 2017  higi, the health IT company ... North America , today announced a Series ... acquisition of EveryMove. The new investment and acquisition accelerates ... tools to transform population health activities through the collection ... higi collects and secures data today on ...
(Date:3/24/2017)... 2017 The Controller General of Immigration from Maldives ... Algeen have received the prestigious international IAIR Award for the most ... Reading ... Maldives ... Abdulla Algeen (small picture on the right) have received the IAIR award ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... Austin, TX (PRWEB) , ... October 11, 2017 ... ... in August compared the implantation and pregnancy rates in frozen and fresh ... the contribution of progesterone and maternal age to IVF success. , After comparing ...
(Date:10/10/2017)... ... , ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled ... bold new look is part of a transformation to increase awareness, appeal to new ... , It will also expand its service offering from its signature gourmet cooking classes ...
(Date:10/10/2017)... Philadelphia, PA (PRWEB) , ... October 10, 2017 ... ... University City Science Center’s FirstHand program has won a US2020 STEM Mentoring Award. ... accept the award for Excellence in Volunteer Experience from US2020. , US2020’s mission ...
(Date:10/10/2017)... International research firm Parks Associates announced today that ... TMA 2017 Annual Meeting , October 11 in Scottsdale, ... security market and how smart safety and security products impact the competitive ... Parks Associates: Smart Home Devices: Main ... "The residential security market has experienced continued ...
Breaking Biology Technology: