Navigation Links
New clues to the dark side of a key anti-tumor guardian

Although researchers over recent years have established a foothold in understanding how p53 protects against cancer, the mechanisms by which it might contribute to aging and lifespan are not well studied. In work reported this week, researchers studying p53 function in fruit flies show new evidence that despite the protective role of p53 as a guardian against tumor formation, normal levels of p53 activity--at least in some cell types--may indeed contribute to aging and decreased lifespan.

The p53 protein is known to be a critical player in our body's natural defense against cancer--it is absent in many types of tumor cells--but it also represents an intriguing paradox when it comes to the broader roles this protein plays in our well being. Past work has shown that in animal models, hyperactivation of the p53 protein is beneficial in terms of bestowing extra protection against tumor formation, but at the same time it has a significant negative effect: a shortening of lifespan, accompanied by hallmarks of accelerated aging, including osteoporosis, decreased stress resistance, and organ atrophy.

The work is reported by Stephen Helfand and colleagues at Brown Universtiy, University of Connecticut Health Center, and University of Texas Southwest Medical Center.

The researchers investigated the role of p53 in aging by observing the effects of disrupting this protein in the neurons of adult fruit flies. They found that expression of a so-called "dominant-negative" version of p53--that is, a disfunctional version of the protein that inhibits the activity of normal p53--extended flies' life span and increased their ability to withstand gene-damaging stress. The authors found that this disruption of p53 did not further increase the lifespan of flies on a calorie-restricted diet, suggesting that decreased p53 activity and calorie restriction may influence lifespan through a common molecular mechanism.

Because neurons are less prone to tumor for mation than other cell types, and because disruption of p53 activity in neurons was sufficient to extend lifespan in the fruit fly, the new findings suggest that by attending to p53 activity in different cell types, it may be possible to take therapeutic advantage of p53's tumor-preventing activity while avoiding its unwanted negative effects on lifespan.


'"/>

Source:Cell Press


Related biology news :

1. Insight into DNAs weakest links may yield clues to cancer biology
2. High-powered gene profiles provide clues to genes involved in common form of lung cancer
3. Genetic links could unlock clues to leading cause of blindness
4. ORNL, UC Berkeley unravel real-world clues to Earths mysteries
5. Elderly mice yield clues to the process of growing old
6. Engineered skin offers clues to melanoma development
7. Scientists uncover new clues about brain function in human behavior
8. On a wing and a prayer - Alaska researchers seek clues to bird flu
9. Infection alarm yields clues to immune system behavior
10. Pair of studies offer new clues to combat antibiotic resistance
11. Ancient DNA provides clues to the evolution of social behavior
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. (NASDAQ: ... announces the filing of its 2016 Annual Report on Form 10-K ... Commission. ... 10-K is available in the Investor Relations section of the Company,s ... the SEC,s website at http://www.sec.gov . 2016 Year ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, ... secure authentication solutions, today announced that it has ... Advanced Research Projects Activity (IARPA) to develop next-generation ... program. "Innovation has been a driving ... Thor program will allow us to innovate and ...
(Date:4/11/2017)... , April 11, 2017 NXT-ID, Inc. ... technology company, announces the appointment of independent Directors Mr. ... to its Board of Directors, furthering the company,s corporate governance ... Gino ... we look forward to their guidance and benefiting from their ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... -- Kinexum, a distinguished resource for research, development and commercialization ... Thomas C. Seoh as President and CEO. Mr. ... who becomes Executive Chairman and will continue to serve ... Thomas Seoh commented, "I am excited and ... the firm,s remarkable team of life science professionals, all ...
(Date:4/26/2017)... ... April 26, 2017 , ... ... its new Bioflash MailGuardtm mail security screening solution at the National Postal Forum ... MailGuard system provides a fast, highly accurate, easy to use and low cost ...
(Date:4/25/2017)... ... 2017 , ... Franz Inc ., an early innovator ... market leader for Semantic Graph Database technology, today announced Allegro ... effective system for developing and deploying applications to solve the challenges developers face ...
(Date:4/25/2017)... ... 25, 2017 , ... Leaders of Quorum Review IRB and ... sessions at this week’s Association of Clinical Research Professionals (ACRP) 2017 Meeting & ... research. , "We are excited to present subject matter expertise on topics that impact ...
Breaking Biology Technology: