Navigation Links
New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity

Scientists at Lawrence Livermore National Laboratory (LLNL) and the Linnaeus Centre for Bioinformatics (LCB) at Uppsala University in Sweden have developed a new bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity. The cooperative efforts were headed by Krzysztof Fidelis in the United States and by Jan Komorowski in Sweden.

Understanding the complex regulatory mechanisms that tell genes when to switch on and off is one of the toughest challenges facing researchers attempting to discover how life works. "Binding sites," or areas of DNA that interact with the proteins that help control gene expression, can be a long distance on the DNA strand from the genes they influence. Recent research also has shown that gene expression can be controlled by several regulatory proteins working together at a combination of different binding sites.

(Regulatory proteins are known as "transcription factors"; transcription is the first step in the process by which the genetic information in DNA is decoded by the cell to manufacture proteins, the building blocks of life.)

"It's difficult to experimentally observe how transcription factors bind to DNA at a distance from a gene, or how regulation happens," said Fidelis, a computational biologist in Livermore's Biosciences Directorate. "But you can identify their binding sites in a promoter or regulatory region - there are usually a few of these for each gene. We wanted to see if we could somehow deduce how many transcription factors at a time, or combinations of factors, are coming together physically and how these combinations regulate genes."

"To accomplish this," Komorowski said, "we used a machine learning technique called rough sets to mathematically model general rules that could associate known binding sites and gene expression in yeast, which is one of the most widely studied organisms." From the analysis of gene activity under a variety of environm
'"/>

Source:LLNL


Page: 1 2

Related biology news :

1. European Commission funds EBI to do new research on synergies between bioinformatics and medical informatics
2. Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu
3. New lab technique identifies high levels of pathogens in therapy pool
4. Brain-mapping technique aids understanding of sleep, wakefulness
5. Study reveals new technique for fingerprinting environmental samples
6. Researchers pioneer new gene therapy technique using natural repair process
7. Newer imaging techniques may lead to over-treatment
8. Gene silencing technique offers new strategy for treating, curing disease
9. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
10. Researchers devise new technique for creating human stem cells
11. New technique rapidly detects illness-causing bacteria
Post Your Comments:
(Date:4/21/2015)... High crime rate, increasing ... access control systems market in Saudi Arabia ... published report by TechSci Research " Saudi Arabia Access Control ... systems market in Saudi Arabia ... control systems market in the Kingdom is growing at ...
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... , April 23, 2010 , Carlos Moreira , Chairman and Founder ... address to a selected audience of over 500,entrepreneurs and members of the science ... week-end in Cambridge,Massachusetts . , , ... Carlos Moreira will debate some of these initiatives ...
... Molecular biologist Alan Ashworth, Ph.D., FRS, the director of ... Cancer Research in London will receive the David T. Workman ... $50,000 from the Samuel Waxman Cancer Research Foundation will support ... "I,m both surprised and delighted that the Waxman Foundation has ...
... been working for more than a decade to understand ... Now researchers have discovered that microRNA actually moves between ... ultimately determine the types of cells that grow and ... wide range of fields, including medical gene therapy and ...
Cached Biology News:WISeKey Announce New Services and Solutions for Latin America at MIT 2WISeKey Announce New Services and Solutions for Latin America at MIT 3Alan Ashworth to receive award for his breakthrough work in breast cancer 2Production of biofuels could benefit by controlling the types of cells that develop in plants 2
(Date:4/21/2015)... , April 21, 2015  Novogen Limited (ASX:NRT; ... biotechnology company, advises that it has entered into ... fully-paid ordinary shares plus one attaching 6-month option ... every ordinary share issued, to institutional investors in ... a private placement for aggregate gross proceeds of ...
(Date:4/21/2015)... Springfield, Mo. (PRWEB) April 21, 2015 ... vessels, HOLLOWAY AMERICA is slated to discuss its custom ... also present its reimagined website, which launched just prior ... Wed. and Thurs. (April 21, 22 and 23) at ... than 12,000 representatives of the world’s largest and most ...
(Date:4/20/2015)... NC and Champaign, IL (PRWEB) April 20, 2015 ... today the establishment of its 12th clinical research site: ... PMG Research has assumed operation of the clinical research ... expanding PMG’s footprint outside the Southeast to a second ... within a 150 multi-specialty physician practice enhances PMG’s access ...
(Date:4/20/2015)... -- "Everybody is affected by cancer sooner or later," Dr. ... We,ve got to get away from that."  If you,ve ... loved one or friend battling for their life against ... other treatments cause the human body. It,s almost enough ... succumb to the disease. Dr. Dionne has developed a ...
Breaking Biology Technology:Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 2Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 3Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 4Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 5Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 6HOLLOWAY AMERICA to Reveal Newly Designed Responsive Website at INTERPHEX 2015 Today 2HOLLOWAY AMERICA to Reveal Newly Designed Responsive Website at INTERPHEX 2015 Today 3PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Is Dr. Craig Dionne the Steve Jobs of Cancer Research? 2
... San Francisco or Boston, and youre on the verge of investing ... right: The management team is in place, the business plan is ... a lawyer steps into the room, clears her throat and asks ... not write that check, she says, until you learn more about ...
... Inc. has received a written notification from the ... file financial reports for the quarter ending March 31, 2006 ... stock from NASDAQ. , ,Representatives of Merge, which does ... Qualifications Panel to request that the panel grant Merge an ...
... - Who needs a record label? Independent musicians can now ... and sell it five minutes later, courtesy of a new ... technology firm's Web Hosting 2.0 represents a customization expansion over ... users to host their existing Web site with Broadjam, or ...
Cached Biology Technology:Why repealing the shareholder wage lien law makes sense 2Why repealing the shareholder wage lien law makes sense 3
Mouse monoclonal antibody to PDK2 - pyruvate dehydrogenase kinase, isoenzyme 2...
... selection system for recombinant identification. Recombinant selection ... need for costly color screening. This quick ... accuracy in recombinant selection. pLivSelect is also ... This cloning kit can be used for ...
Mouse monoclonal to Casein Kinase 2 beta ( Abpromise for all tested applications). entrezGeneID: 1460 SwissProtID: P13862...
Alpha-2-antiplasmin precursor (Alpha-2-plasmin inhibitor) (Alpha-2-PI) (Alpha-2-AP). [Source:Uniprot/SWISSPROT;Acc:P08697] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: