Navigation Links
New binding target for oncogenic viral protein

The DNA tumor virus simian virus 40 produces the Large T antigen which inactivates two of the cell's most important cancer-preventing proteins, p53 and pRb. In a study published in the Journal of Biological Chemistry, researchers at the Fred Hutchinson Cancer Research Center report the discovery of an additional target for T antigen--a protein called Fbw7.

The Fbw7 gene is located in a chromosomal region that is deleted in up to 30% of human tumors. "Fbw7 is itself an important tumor suppressor which makes it an attractive choice for inactivation by Large T," explained Dr. Markus Welcker, the study's first author.

The research appears as the "Paper of the Week" in the March 4 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

DNA tumor viruses proliferate by hijacking their host cell's DNA replication machinery. In order to do this, they have evolved mechanisms to override normal cellular replication controls. Simian virus 40 (SV40) accomplishes this task by producing the highly oncogenic large T antigen. This protein corrupts the cellular checkpoint mechanisms that guard cell division and the transcription, replication and repair of DNA. T antigen also inactivates some of the most important proteins that protect cells against malignant transformation, including tumor suppressor proteins p53 and pRb.

In the Journal of Biological Chemistry paper, Dr. Welcker and Dr. Bruce Clurman report that T antigen also binds to another tumor suppressor, Fbw7. This protein is part of a ubiquitin ligase complex that adds ubiquitin to proteins to mark them for destruction by the cell. Fbw7 recognizes a destruction signal on certain proteins that need to be degraded and brings them in close proximity to the enzymes that attach ubiquitin. The proteins recognized by Fbw7 play key roles in cell division, cell growth, differentiation, and cell death.

"These proteins are also some of the
'"/>

Source:American Society for Biochemistry and Molecular Biology


Page: 1 2

Related biology news :

1. Ancient olfaction protein is shared by many bugs, offering new pest control target
2. A bacterial genome reveals new targets to combat infectious disease
3. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
4. Researchers identify target for cancer drugs
5. Study reveals candidate targets for anti-retroviral therapeutics
6. MUHC researchers make cancer target breakthrough
7. Future diabetes drugs may target new protein interaction
8. Smart drug targets deadly brain cancer
9. NHGRI targets 12 more organisms for genome sequencing
10. While on trail of dioxin, scientists pinpoint cancer target of green tea
11. Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New binding target for oncogenic viral protein

(Date:5/23/2013)... mechanism by which estrogen suppresses lipid synthesis in the ... approach toward treating certain liver diseases. , With ... are changing long-held views in the field. Study results ... Science Signaling . , "The dogma in the ... only receptors located in the nucleus respond to steroid ...
(Date:5/23/2013)... Given the implications for the overall health, development, ... a primary role in ensuring that all students ... minutes per day of vigorous or moderate-intensity physical ... of Medicine. Recent estimates suggest that only ... guideline for promoting better health and development. ...
(Date:5/23/2013)... 2013) A new report from the Institute of ... engage in at least 60 minutes of vigorous or ... more than half of American youth meet current evidence-based ... moderate intensity physical activity daily, according to the report, ... in school for nearly half of their waking hours, ...
Breaking Biology News(10 mins):UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis 2Schools should provide opportunities for 60 minutes of daily physical activity to all students 2Schools should provide opportunities for 60 minutes of daily physical activity to all students 3Schools should provide students with daily physical activity, IOM recommends 2
... 5, 2007) As if being admitted to the ... higher risk of becoming infected with a superbug bacterium, ... difficile kill human intestinal cells by causing them to ... fuel. This results in severe diarrhea and, in rare ...
... dog-walking in bushland significantly reduces bird diversity and ... practice in sensitive bushland and conservation areas. ... impacts of dog-walking have remained subjective and unresolved ... the first clear evidence that birds perceive dogs ...
... know. The supermarket headlines tell us so., Inquiring Texas ... B a tiny, sometimes obscure pest that can damage ... to young cotton for about four weeks," said Dr. ... Lubbock. "They feed on new plant growth, primarily the ...
Cached Biology News:Curbing C. difficile's toxin production 2A dog in the hand scares birds in the bush 2Inquiring minds want to know about cotton fleahoppers 2Inquiring minds want to know about cotton fleahoppers 3
(Date:5/24/2013)... May 24, 2013 Quincy Bioscience, ... and development of calcium-binding proteins to support healthy ... safety assessment study of apoaequorin in ... published for the British Industrial Biological Research Association. ... to investigate potential adverse effects, if any, of ...
(Date:5/23/2013)... Can economic incentives such as gift cards, T-shirts, ... public to increase their donations of blood? , A ... School Assistant Professor Mario Macis says the answer ... of recent research that supports their argument, the three ... Science that the World Health Organization and national blood ...
(Date:5/23/2013)... The maker community is a contemporary ... They focus on learning practical skills while applying them ... bringing their ideas to life via crowdfunding. A subgroup ... making projects using biology. Glowing Plant has worked for ... them glow with bioluminescence genes, and has now pursued ...
(Date:5/23/2013)... BioTrends Research Group, one of the ... biopharmaceutical issues, finds that, unaided, one in five ... that in the past six months, they have ... anticipation of the next generation of HCV treatments—notably ... 6 percent reported that they had begun warehousing ...
Breaking Biology Technology:Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 3Glowing Plant Releases Maker Kit, Enabling Anyone to Make a Glowing Plant at Home 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3
... Heritage Labs, a,division of Hooper Holmes (Amex: ... a new at-home consumer product that measures the ... The Appraise(R) Home,A1c Kit provides consumers with an ... and reliable test results equivalent to whole,blood tests ...
... YORK, Aug. 7 Keryx Biopharmaceuticals,Inc. (Nasdaq: KERX ... 11, 2008,at 8:30 a.m. EDT to discuss the second ... Executive Officer of the Company, will,host the call. Keryx ... press release to be issued prior to the call., ...
... (OTC Bulletin Board: GNTA) today announced financial results,for the ... in the second quarter, including the following:, -- ... -- AGENDA Phase 3 trial of Genasense in ... tesetaxel, a leading, clinical-stage oral taxane,lifted by FDA, ...
Cached Biology Technology:Hooper Holmes' Heritage Labs Division Launches New Home Diabetes Test 2Hooper Holmes' Heritage Labs Division Launches New Home Diabetes Test 3Hooper Holmes' Heritage Labs Division Launches New Home Diabetes Test 4Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2008 Financial Results on Monday, August 11, at 8:30 A.M. EDT 2Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 2Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 3Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 4Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 5Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 6Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 7Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 8Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 9Genta Incorporated Announces Second Quarter 2008 Financial Results and Corporate Highlights 10
Recombinant Equine TNF-alpha/TNFSF1A, CF...
GRADIENT MAKER, 30 ML, 1 EA. Category: Protein Vertical Instruments....
DALT GRADIENT MAKER,230V, 1 EA. Category: 2D DALT Systems....
Rat whole blood (Sprague-Dawley, averaging 7-8 weeks of age, either sex) is collected at the time of slaughter and refrigerated within 6 hours, and processed and frozen within 24 hours. The serum is ...
Biology Products: