Navigation Links
New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

scribed; most sites of transcription were not located in areas associated with protein-coding genes.

The team found many diverse kinds of RNAs transcribed from distinct regions of the genome, creating a complex pool of overlapping transcription. While the team validated many known protein-coding transcripts that contribute to this complex pool, they also discovered that:


Seventy-five percent of all of the RNA that were exclusively found in the nucleus had not been previously detected.
Any single base in the genome can be transcribed into several different transcripts with different, but overlapping sequences. Often, transcripts from one strand of DNA can share parts of their sequence with overlapping transcripts from the same strand or even from the opposite strand (antisense).
Transcripts missing a run of adenosine nucleotides (non-polyA) at the tail-end were twice as common as the more well-studied RNAs that have this sequence. Most transcripts derived from the sparsely transcribed regions between centers of dense transcription are non-polyA transcripts.

This study focused on an in depth scan of 10 chromosomes; however, Affymetrix has developed tiling microarrays that cover all human chromosomes. GeneChip tiling microarrays have been used by Gingeras and his collaborators, as well as the NHGRI publicly funded ENCODE project, to study the human genome in an unbiased fashion -- including regions that have historically been termed coding and non-coding.

Affymetrix is now beginning to commercialize tiling microarrays to give the research community the ability to perform these types of unbiased studies as well. By focusing research beyond the parts of the genome that have been traditionally studied, scientists hope to discover new drug targets, new biomarkers, and a better understanding of disease mechanism.

This project has been funded in whole or in part with Federal Funds from the National Cancer Institute,
'"/>

Source:Affymetrix


Page: 1 2 3

Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
8. Study finds more than one-third of human genome regulated by RNA
9. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
10. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
11. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
Post Your Comments:
(Date:4/13/2015)... -- higi, a leading cloud-based consumer engagement platform that provides ... their communities around health and wellness, announced today the ... ... convenient vehicle to receive validated health information from consumers. ... API will allow higi,s trusted partners, on a user ...
(Date:4/6/2015)... 6, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/143028 for MINIATURE, MULTI-PURPOSE ANTENNA METHOD AND ... NXT-ID introduces a new revolutionary method and ... the use of miniature antenna modules for multiple ...
(Date:4/2/2015)... , April 2, 2015 ... touch fingerprint sensor FPC1025 from the distributor World Peace ... commence during Q2 2015 although the major part of ... sensors will be used by smartphone manufacturers in ... MSEK is included in the communicated revenue guidance of ...
Breaking Biology News(10 mins):higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... WAVCIS Program and also of the Coastal Studies Institute in ... published estimates that more than 75 percent of the oil ... participated in a three-hour flyover of the affected area in ... visible from overhead. "It,s most definitely there," said Stone. ...
... Congress to take legislative action that will allow federal ... in light of U.S. District Judge Royce Lamberth,s refusal ... research using embryonic stem cells. Research!America strongly ... introduced in March 2010 by Representatives Diana DeGette (D-CO) ...
... The potential for outbreaks of spruce and mountain ... to increase significantly in the coming decades, according to ... their colleagues. Their findings, published in the September issue ... comprehensive synthesis of the effects of climate change on ...
Cached Biology News:LSU's WAVCIS director says oil remains below surface, will come ashore in pulses 2Research!America asks Congress to support embryonic stem cell research now 2Risk of beetle outbreaks rise, along with temperature, in the warming West 2
(Date:4/17/2015)... Reed Technology and Information Services ... management, preparation, and submission to the U.S. Food and ... new Lot Distribution Report (LDR) service for manufacturers of ... with the FDA’s new rule on electronic submission of ... the volume and timing of particular biologics introduced to ...
(Date:4/17/2015)... Global Stem Cells Group has ... 2015 April 27 - 29, 2015 in Boston. This ... areas of stem cell research including applications, biology, medicine, ... medicine. , The conference will address recent developments ... research in stem cell therapies, regenerative medicine, tissue engineering, ...
(Date:4/16/2015)... 16, 2015 Cambridge Semantics ... driven by Semantic Web technology, and Informa ... and services for the academic and scientific, professional ... joint solution ‘Smart Data Lake for Clinical Trial ... the 2015 Bio-IT ‘Best of Show’ Award. ...
(Date:4/16/2015)... Regis Technologies looks forward to being part ... (AACR) annual meeting. Regis will exhibit at this year's ... 18, in Philadelphia and running through April 22, 2015. ... oldest and largest organization focused on cancer research. It ... with survivors to promote awareness and research funding. ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 2Cambridge Semantics and Informa Named Bio-IT Award Finalist for Smart Data Lake Solution for Clinical Trial and Competitive Intelligence 3Regis Technologies Joins American Association for Cancer Research Annual Meeting 2
...  VisionGate, Inc., a company developing a revolutionary non-invasive test ... applications, today reported that it has achieved full automation ... generates high-resolution 3D biosignatures from intact cells.  Development of ... by a $2.6 million grant from the National ...
... human body is moved by its strongest muscles: When we ... are working on the surface of our teeth. "What the ... inlays or bridges", glass chemist Prof. Dr. Dr. Christian Rssel ... these are worn as much as healthy teeth. Ceramic materials ...
... Jan. 5, 2012 Billy Butler, designated hitter for the Kansas ... The award is given each year to a Major League Baseball ... great Fred Hutchinson, both on and off the field. ... keynote address at the Hutch Award Luncheon and presentation on Feb. ...
Cached Biology Technology:VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer 2VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer 3VisionGate Uses $2.6 Million NIH Grant to Achieve Full Automation of Cell-CT™ 3D Imaging System for Early Diagnosis of Cancer 4Nanocrystals make dentures shine 2Royals Batter Billy Butler Named Hutch Award Winner 2
Rabbit polyclonal to Aortic Elastin ( Abpromise for all tested applications). entrezGeneID: 2006 SwissProtID: P15502...
Rabbit polyclonal to GPR56 ( Abpromise for all tested applications). entrezGeneID: 9289 SwissProtID: Q9Y653...
Mouse monoclonal [2A4] to Cytokeratin 8 + 18 + 19 ( Abpromise for all tested applications). Antigen: Cytokeratins isolated from cultured pig kidney epithelial cells. Entrez GeneID: 3856 S...
Feline Rhinotracheitis Virus...
Biology Products: