Navigation Links
New RNAi tools enable systematic studies of gene function

An international public-private research team led by scientists at the Broad Institute of MIT and Harvard announced today the construction and availability of an extensive library of molecular reagents to silence most human and mouse genes.

As described in the March 24 issue of Cell, this library consists of small RNA molecules that can switch off genes individually, allowing the user to dissect the genetic underpinnings of normal biology and disease. These RNA-interference (RNAi)-based gene inhibitors are packaged in lentiviruses, enabling their use in virtually all types of human and mouse cells. This work springs from the RNAi Consortium (TRC), a unique collaboration among academic research institutions and leading life science companies with the mission to build comprehensive RNAi libraries and make them available to scientists worldwide.

"Switching off a single gene through RNAi reveals how that gene functions in a particular biological process. When RNAi's potential is applied to thousands of genes ?as it has been in fruit flies and nematodes ?it can provide a more complete picture of that process," said David Root, a senior author of the Cell paper and the director of TRC and the RNAi platform at the Broad Institute. "Thanks to this unique public-private effort, we now have new tools to enable the entire research community to realize the potential of RNAi in the two most important species in biomedicine."

"The RNAi library developed by TRC is a rich resource for biological discovery," said Nir Hacohen, assistant professor at Massachusetts General Hospital and Harvard Medical School, associate member of the Broad Institute and a senior author. "Ongoing studies in my own laboratory to understand how the immune system senses pathogens and appropriately targets its response will be accelerated using these tools."

RNAi gives scientists the ability to turn off an individual gene. Its workhorses are small RNA molecules, each of which i
'"/>

Source:Broad Institute of MIT and Harvard


Page: 1 2 3

Related biology news :

1. Improved statistical tools reveal many linked loci
2. Virginia Tech group adds tools to DNA-targeted anti-cancer drugs
3. New tools used to control foodborne hepatitis A outbreaks related to green onions
4. MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools
5. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
6. Discovery of new molecular tools for biosynthesis could lead to advances in use of pectin
7. Recycled paper and compost could both be key tools to control plant disease
8. Nanotech tools yield DNA transcription breakthrough
9. Molecular tools make the cut
10. Chimpanzees found to use tools to hunt mammalian prey
11. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New RNAi tools enable systematic studies gene function

(Date:9/12/2014)... come under attack from a pathogen, they sometimes respond ... the attack, committing "cell suicide" to thwart further damage ... small, often microscopic, spots or lesions on the plant. ... understand how the plant regulates this "spotty" defense mechanism ... Researchers at North Carolina State University have identified a ...
(Date:9/12/2014)... and POINT ROBERTS, Washington , September 12, ... http://www.investorideas.com ) a global news source covering leading sectors including ... on the September 9 th launch of Apple Pay, ... Intelligence, Janice Kephart , founder of the Secure Identity ... of NXT-ID, Inc, (NASDAQ: NXTD ) a company ...
(Date:9/11/2014)... Amsterdam, NL, 11 September 2014 Patients with ... preparation and ingestion, which could contribute to poor ... Published studies have also suggested that PD is ... control groups. A report published in the ... in patients with mild-to-moderate PD, finding that the ...
Breaking Biology News(10 mins):Corn spots: Study finds important genes in defense response 2Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 2Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 3Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 4Biometric Experts Comment on Launch of Apple Pay Smart Wallet Payment Service 5Few mild-to-moderate Parkinson's disease patients suffer from malnutrition, yet almost one-third are at risk 2
... Study of Hepatitis C (PEDS-C) trial reveals that children ... display significant changes in height, weight, body mass index ... issue of Hepatology , a journal of the ... that most growth-related side effects are reversible with cessation ...
... New Rochelle, NY, August 9, 2012Despite criticism from Congressional ... its Rim of the Pacific (RIMPAC) 2012 international maritime ... 50% biofuels blend. The Navy contends that renewable energy ... play in enhancing national security and energy independence. Tom ...
... University researchers are teaming up with Coastal Carolina University ... along the Savannah River to gather data for the ... and transmit real-time information about the quality and quantity ... project leaders Gene Eidson, director of Clemson,s Institute of ...
Cached Biology News:Height, weight and BMI changes seen in children treated with peginterferon alpha for hepatitis C 2US Navy defends renewable fuels strategy in Industrial Biotechnology Journal 2Clemson, Coastal Carolina universities to set hundreds of sensors in Savannah River 2
(Date:9/11/2014)... sheet of carbon, can be randomly decorated with oxygen ... could have a significant impact on the chemical, pharmaceutical ... an ultra-strong, non-corrosive coating for a wide range of ... used to paint various surfaces ranging from glass to ... treatment, the resulting coatings behave like graphite in terms ...
(Date:9/11/2014)... 2014 The Registration Committee today ... now open for Pittcon 2015, the world’s largest ... event will be held March 8-12, 2015, at ... , The discounted registration fee of $175 ... 2/20/2015). This affordable price includes unlimited week-long access ...
(Date:9/11/2014)... , Sept. 11, 2014 /PRNewswire/ - Portage Biotech ... Securities Exchange: PBT.U), announces that it intends to ... US$ 2 million for funding its preclinical development ... Company Limited, ("Biohaven"). The Company is ... to 20 million common shares at a price ...
(Date:9/11/2014)... Awarded annually by Germany’s Design ... internationally recognized quality label for excellent design. METTLER ... coveted Red Dot award in recognition ... Powder Dispenser (HPD). , The Quantos Handheld ... and ease-of-use to applications involving free-flowing powders. Forget ...
Breaking Biology Technology:Graphene paints a corrosion-free future 2Conferee Registration Opens for Pittcon 2015; Housing & Travel Open for Reservations 2Portage Announces Proposed Private Placement 2Portage Announces Proposed Private Placement 3Portage Announces Proposed Private Placement 4METTLER TOLEDO Handheld Powder Receives Red Dot Award for Product Design 2
... Enanta Pharmaceuticals, Inc. announced today that its lead ... inhibitor program, EDP-239, has been recognized on Windhover,s list ... to Watch." EDP-239 was chosen by independent experts at ... a clinically-validated target, is a non-structural viral protein that ...
... at deCODE Genetics and academic collaborators from Iceland, The Netherlands, ... today report the discovery of a variant in the sequence ... cell carcinoma of the skin (BCC), as well as prostate ...  The study was done in collaboration with Illumina, Inc., and ...
... Sept. 23, 2011 Citizens Bank today announced that ... a major expansion by The Wistar Institute that includes ... historic facility at 36th and Spruce streets in University ... an international leader in basic biomedical research, particularly cancer ...
Cached Biology Technology:Enanta's Lead NS5A Inhibitor Candidate for HCV, EDP-239, Selected as One of Windhover's Top 10 Infectious Disease Projects to Watch 2Enanta's Lead NS5A Inhibitor Candidate for HCV, EDP-239, Selected as One of Windhover's Top 10 Infectious Disease Projects to Watch 3deCODE genetics, Together with Academic Collaborators and Illumina, Discovers Genetic Risk Factor for Skin, Prostate and Brain Cancers 2deCODE genetics, Together with Academic Collaborators and Illumina, Discovers Genetic Risk Factor for Skin, Prostate and Brain Cancers 3Citizens Bank Provides $70 Million in Financing Toward $100 Million Expansion of The Wistar Institute 2
Mouse monoclonal antibody to UGT2B10 - UDP glucuronosyltransferase 2 family, polypeptide B10...
... cleanup kit is a sample preparation kit ... by removal of detergents, phenolic compounds, salts, ... concentrates dilute samples. The kit procedure involves ... mammalian tissue or cells, plant leaves, E. ...
... XIII in both reduced and non-reduced forms. It ... or human Factor XII. Factor XIII is a ... two subunits. Factor XIII-A is the catalytic subunit ... XIII is present in plasma as an Alpha2Beta2 ...
Rabbit polyclonal to Retinoic Acid Receptor beta 2 ( Abpromise for all tested applications). entrezGeneID: 5915...
Biology Products: