Navigation Links
New GM mosquito sexing technique is step towards malaria control, report scientists

Scientists have genetically modified male mosquitoes to express a glowing protein in their gonads, in an advance that allows them to separate the different sexes quickly.

By providing a way to quickly sex mosquitoes, the advance paves the way for pooling large numbers of sterile males which could be used to control the mosquito population.

Research published online today in Nature Biotechnology, shows how a team from Imperial College London have altered male mosquitoes to express a green fluorescent protein in their gonads. Coupled with a high speed sorting technique, scientists will be able to identify and separate the different mosquito sexes much more easily than by manually sorting.

Professor Andrea Crisanti, senior author of the paper, from Imperial College London, said: "This advance could have enormous implications for controlling mosquito populations. Now that we can identify males and females at an early stage, it will be possible to release sterile males into the population without the risk of releasing additional females. The release of sterile males has proven effective in controlling several insect pests when methods for sorting sex are available.

"Female mosquitoes are responsible for spreading malaria, and also for damage to crops, but they are only able to breed once before dying. By forcing females to breed with sterile males, we can stop them creating additional mosquitoes and at the same time, reduce the population."

The team used the mosquito Anopheles stephensi, the mosquito responsible for much of the malaria in Asia. They engineered the mosquito larvae to express an enhanced green fluorescent protein (EGFP). The modified larvae were mixed with normal larvae, and the researchers were able to identify the modified male mosquitoes by their fluorescent gonads.

When the genetically modified mosquitoes were mixed with normal male and female mosquitoes, they found the females were as likely to breed with the modified mosquitoes as they were with the normal ones.

This work builds on earlier work by the Imperial team published in 2000, demonstrating for the first time the insertion of a foreign gene into the mosquito genome. This raised the possibility that genetic manipulation could be used as a control method in mosquito populations.

Professor Crisanti adds: "Although there have been a number of control programmes to eradicate malaria, none of these have been entirely successful, and many have also had side effects, such as environmental damage through insecticides. This advance could one day make a major impact on the burden of ill health caused by malaria, and is another step towards how genetic modification can be used safely to deal with global problems."


'"/>

Source:Imperial College London


Related biology news :

1. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
2. Fighting malaria by manipulating mosquitoes sense of smell
3. Gene that helps mosquitoes fight off malaria parasite identified
4. Genetically engineered mosquitoes show resistance to dengue fever virus
5. Oxidation defense in mosquitoes benefits malaria parasite
6. Malaria vaccine prompts victims immune system to eliminate parasite from mosquitoes
7. Genome of yellow fever/dengue fever mosquito sequenced
8. New lab technique identifies high levels of pathogens in therapy pool
9. Brain-mapping technique aids understanding of sleep, wakefulness
10. Study reveals new technique for fingerprinting environmental samples
11. Researchers pioneer new gene therapy technique using natural repair process
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
(Date:3/21/2016)... Unique technology combines v ... security   Xura, Inc. ... digital communications services, today announced it is working alongside ... customers, particularly those in the Financial Services Sector, the ... within a mobile app, alongside, and in combination with, ...
(Date:3/14/2016)... NXTD ) ("NXT-ID" or the "Company"), a company ... of a new series of commercials on Time Warner Cable ... .  The commercials will air on Bloomberg TV, Fox Business ... show. --> NXTD ) ("NXT-ID" or the "Company"), ... the airing of a new series of commercials on Time ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... Phoenix, AZ (PRWEB) , ... May 25, 2016 ... ... Arizona, Dr. Michael Fitzmaurice recently became double board-certified in surgery and surgery of ... 31, 2015. Dr. Fitzmaurice is no stranger to going above and beyond in ...
(Date:5/25/2016)... ... May 25, 2016 , ... Scientists at the University of Athens say ... mesothelioma may be hampering the research that could lead to one good one. Surviving ... read it now. , The team evaluated 98 mesothelioma patients who ...
(Date:5/25/2016)... ... 2016 , ... Lady had been battling arthritis since the age of two ... knee. Lady’s owner Hannah sought the help of Dr Jeff Christiansen of Superior ... cruciate ligament and help with the pain of Lady’s arthritis. Dr Christiansen suggested that ...
(Date:5/24/2016)... , ... May 24, 2016 , ... ... diabetes, and traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute ... engines of wound healing and tissue regeneration. , The novel method, developed by ...
Breaking Biology Technology: