Navigation Links
New GM mosquito sexing technique is step towards malaria control, report scientists

Scientists have genetically modified male mosquitoes to express a glowing protein in their gonads, in an advance that allows them to separate the different sexes quickly.

By providing a way to quickly sex mosquitoes, the advance paves the way for pooling large numbers of sterile males which could be used to control the mosquito population.

Research published online today in Nature Biotechnology, shows how a team from Imperial College London have altered male mosquitoes to express a green fluorescent protein in their gonads. Coupled with a high speed sorting technique, scientists will be able to identify and separate the different mosquito sexes much more easily than by manually sorting.

Professor Andrea Crisanti, senior author of the paper, from Imperial College London, said: "This advance could have enormous implications for controlling mosquito populations. Now that we can identify males and females at an early stage, it will be possible to release sterile males into the population without the risk of releasing additional females. The release of sterile males has proven effective in controlling several insect pests when methods for sorting sex are available.

"Female mosquitoes are responsible for spreading malaria, and also for damage to crops, but they are only able to breed once before dying. By forcing females to breed with sterile males, we can stop them creating additional mosquitoes and at the same time, reduce the population."

The team used the mosquito Anopheles stephensi, the mosquito responsible for much of the malaria in Asia. They engineered the mosquito larvae to express an enhanced green fluorescent protein (EGFP). The modified larvae were mixed with normal larvae, and the researchers were able to identify the modified male mosquitoes by their fluorescent gonads.

When the genetically modified mosquitoes were mixed with normal male and female mosquitoes, they found the females were as likely to breed with the modified mosquitoes as they were with the normal ones.

This work builds on earlier work by the Imperial team published in 2000, demonstrating for the first time the insertion of a foreign gene into the mosquito genome. This raised the possibility that genetic manipulation could be used as a control method in mosquito populations.

Professor Crisanti adds: "Although there have been a number of control programmes to eradicate malaria, none of these have been entirely successful, and many have also had side effects, such as environmental damage through insecticides. This advance could one day make a major impact on the burden of ill health caused by malaria, and is another step towards how genetic modification can be used safely to deal with global problems."


Source:Imperial College London

Related biology news :

1. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
2. Fighting malaria by manipulating mosquitoes sense of smell
3. Gene that helps mosquitoes fight off malaria parasite identified
4. Genetically engineered mosquitoes show resistance to dengue fever virus
5. Oxidation defense in mosquitoes benefits malaria parasite
6. Malaria vaccine prompts victims immune system to eliminate parasite from mosquitoes
7. Genome of yellow fever/dengue fever mosquito sequenced
8. New lab technique identifies high levels of pathogens in therapy pool
9. Brain-mapping technique aids understanding of sleep, wakefulness
10. Study reveals new technique for fingerprinting environmental samples
11. Researchers pioneer new gene therapy technique using natural repair process
Post Your Comments:

(Date:8/23/2017)... general public,s help is being enlisted in what,s thought to be the ... the human body –and are believed to affect health.  ... The Microbiome Immunity Project is the largest study to ... The project's goal is to help advance scientific knowledge of the role ... The ...
(Date:6/30/2017)... 2017 Today, American Trucking Associations announced ... face and eye tracking software, became the newest ... "Artificial intelligence and advanced sensing ... a driver,s attentiveness levels while on the road.  ... detect fatigue and prevent potential accidents, which could ...
(Date:5/23/2017)... , May 23, 2017  Hunova, the first robotic gym for the ... been officially launched in Genoa, Italy . The first ... and the USA . The technology was developed ... market by the IIT spin-off Movendo Technology thanks to a 10 million ... News Release, please click: ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... for two-dimensional representations of a complex biological network, a depiction of a system ... big mess,” said Dmitry Korkin, PhD, associate professor of computer science at Worcester ...
(Date:10/12/2017)... ca (PRWEB) , ... October 12, 2017 , ... ... the Surgical Wound Market with the addition of its newest module, US Hemostats ... $1.2B market for thrombin hemostats, absorbable hemostats, fibrin sealants, synthetic sealants and biologic ...
(Date:10/11/2017)... ... October 11, 2017 , ... The ... endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression plasmids. ... is transformative for performing systematic gain-of-function studies. , This complement to loss-of-function ...
(Date:10/11/2017)... Oct. 11, 2017  VMS BioMarketing, a leading provider of ... oncology Clinical Nurse Educator (CNE) network, which will launch this ... communication among health care professionals to enhance the patient care ... staff, and other health care professionals to help women who ... ...
Breaking Biology Technology: