Navigation Links
New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

dstream, said Derendorf, who has published results from studies that evaluated the technique in people and animals with various infections. In the past, microbiologists would expose bacteria to certain concentrations of an antibiotic and then determine the minimum concentration that prevents bacterial growth. That number was taken and compared with concentrations of the drug in the blood, and from those two numbers a dosing decision is made.

“We feel that’s not the optimal way go,?he said. “It doesn’t give you the full story ?it doesn’t tell you, for example, how quickly the bacteria are killed.?/p>

So UF scientists developed a system of pumps they can use to expose bacteria to changing concentrations of an antibiotic, mimicking the concentration profile present in a patient at the actual site of an infection. They then measure how quickly the bacteria are killed or see if they regrow, and use mathematical modeling to estimate the optimal dose.

“Based on the results in the lab, then you can do a clinical study of what you think is going to work best,?Derendorf said, “and you’d find the best dose much faster than just by going by trial and error or by using some of the traditional ways.?/p>

Consider one recent example: Derendorf led a series of laboratory experiments designed to evaluate an investigational, sustained-release form of a cephalosporin antibiotic. Ultimately the PK/PD approach showed that the difference in drug concentrations in the tissues arising from the standard form of the drug versus the sustained-release variety was so minimal, development of the new formulation was not warranted.

“The company that was interested in that decided not to continue that project any more and made that decision much sooner probably than they would have in earlier days,?said Derendorf, who published the findings in the Journal of Clinical Pharmacology. “Using the information early on to make a ‘no-go?decision for a product so you don’t do
'"/>

Source:University Of Florida


Page: 1 2 3 4

Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. FDA Announces Series of Changes to the Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
3. FDA Warns About Antipsychotic Drugs and Elderly
4. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
5. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
6. Drugs from the deep blue
7. Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
8. Discovery Could Lead To Novel Approaches In HIV Treatment
9. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
10. NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma
11. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Drugs For Bad Bugs Approach Could Bolster Antibiotic Arsenal

(Date:1/22/2015)... MUNICH , January 22, 2015 ... its tenth year  The European Patent Office to present ... Two British nominations to be featured: Christofer Toumazou ... week featuring former finalists and winners of the Award   ...
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
(Date:12/19/2014)... Calif. , Dec. 18, 2014  23andMe, Inc., the leading ... that pinpoints fine-scale differences in genetic ancestry of individuals from ... Since immigrants first arrived more than four hundred years ago, ... a meeting place for peoples from different continents. This study ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... Exotic bacteria that do not rely on oxygen may have ... early atmosphere, according to a theory that UChicago researcher Albert ... volcanic crater in Siberia. He has found that bacteria ... a surprising twist that scientists must take into account as ...
... WASHINGTON, April 26, 2011 The American Chemical Society ... " Global Challenges/Chemistry Solutions " podcast series showcasing ... friendly production of a key ingredient used to make ... and accompanying website focus on a new way to ...
... Group announced today that four individuals, representing Chile, Mexico ... in Marine Conservation. The 2011 Pew Marine ... dolphin populations, measure the economic and ecological tradeoffs of ... scientific foundation for the establishment of marine protected areas ...
Cached Biology News:Cold case: Siberian hot springs reveal ancient ecology 2Cold case: Siberian hot springs reveal ancient ecology 3Pew announces 2011 recipients of distinguished marine conservation fellowship 2
(Date:1/22/2015)... (PRWEB) January 22, 2015 zFlo Motion ... pleased to announce an exciting product from a new partner. ... analysis solutions over the past 15 years, with offerings in ... recently, their 3D IMU system (inertial measurement unit), iSen, is ...
(Date:1/22/2015)... January 22, 2015 Selexis SA, a ... Research Cell Banks (RCBs) used for drug discovery to ... Banks will include Next-Generation Sequencing (NGS) data ... de-risks biologic manufacturing by ensuring the integrity of the ...
(Date:1/22/2015)... DIEGO , Jan. 22, 2015   Cypher ... and Sequenom, Inc. (NASDAQ: SQNM ), ... development agreement for next generation noninvasive prenatal tests ... genome interpretation technology, called Mantis™, to advance analysis ...
(Date:1/22/2015)... PRINCETON, N.J. , Jan. 22, 2015  Derma ... tissue regeneration company focused on advanced wound care, ... from placental tissues, have been added to the ... announcement increases the opportunity for the AMNIOEXCEL® and ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... MADISON, Wis. Platypus Technologies has received a ... grant for $2.14 million from the National Institute ... to continue development of a personal monitor for ... The monitors are designed to be small, sensitive, ...
... with IT shops right now. It's the new magic elixir ... and the music swells. Then we'll go skipping off hand-in-hand ... customers. Yes, I was touting partnership just last week in ... work. Partnership is the right relationship answer only if all ...
... Logicalis , an international IT integration company ... providers, announced Monday it has acquired Solution Technology ... one of IBM's top 10 Business Partners. Logicalis, whose ... letter of intent to purchase a regional HP solution ...
Cached Biology Technology:Blooming partnerships 2Blooming partnerships 3Blooming partnerships 4Logicalis purchases Solution Technology for $90M 2
... GELase™ Agarose Gel-Digesting Preparation contains a unique ... simple, quantitative recovery of intact DNA and ... gels following electrophoresis in TAE, TBE, MOPS, ... digested directly in the TAE, TBE, MOPS, ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
... demand is causing shortages in your laboratory ... This can cause unwanted distractions, problems and ... for your hard work and endeavour! Bring ... it up and market it internationally. We ...
... Perhaps sheer in-house demand is causing shortages ... precious antibody. This can cause unwanted distractions, problems ... royalties for your hard work and endeavour! Bring ... up and market it internationally. We work under ...
Biology Products: