Navigation Links
New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

unrealistic expectations, the requirements are going to be even higher, and it’s going to be harder and even more expensive to bring a new drug to market.?/p>

About 70 percent of bacteria found in hospitals resist at least one of the drugs commonly used to treat the infections they cause, according to the Food and Drug Administration. The agency warns that unless problems are detected early and swift action taken to find substitute drugs, previously treatable diseases could again emerge in more virulent forms. Public health officials cite antibiotic resistance as a growing problem for a host of diseases, from childhood ear infections to malaria.

Last year, the FDA published a report calling attention to inefficiencies in the drug and medical product development process, urging changes to make the process “more predictable and less costly.?The latest estimates put the cost of bringing a new product to market at $1.6 billion to $1.8 billion.

UF researchers are working on an approach known as PK/PD, which combines principles of pharmacokinetics, or an analysis of drug concentrations in the body, and pharmacodynamics, their effect on bacteria or how a drug kills bacteria.

“In the past, blood samples were taken and the serum concentration of the drug was measured and that number was used to make dosing decisions,?said Derendorf, whose work is primarily funded by the pharmaceutical companies Pfizer and Sankyo. “That may not always be the right place to look. Most infections are not in the blood but in other sites of the body. Some of the recommendations we have may not be the optimal doses.?/p>

UF researchers have developed a patent-pending technique called microdialysis that uses a small needle probe to measure how much of a drug actually ends up in the fluid surrounding the bacteria at sites of infection and are among the first in the country to test the method in people. These concentrations can differ widely from those found in the bloo
'"/>

Source:University Of Florida


Page: 1 2 3 4

Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. FDA Announces Series of Changes to the Class of Marketed Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
3. FDA Warns About Antipsychotic Drugs and Elderly
4. Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
5. Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
6. Drugs from the deep blue
7. Engineered Stem Cells Show Promise For Sneaking Drugs Into The Brain
8. Discovery Could Lead To Novel Approaches In HIV Treatment
9. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
10. NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma
11. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New Drugs For Bad Bugs Approach Could Bolster Antibiotic Arsenal

(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... addition of the "iPhone 5S Fingerprint Sensor ... report to their offering. ... acquisition of AuthenTec in July 2012, Apple introduced ... It is currently the only device of Apple ...
(Date:12/19/2014)... 18, 2014  23andMe, Inc., the leading personal genetics ... pinpoints fine-scale differences in genetic ancestry of individuals from ... Since immigrants first arrived more than four hundred ... has served as a meeting place for peoples from ... the ongoing mixing of peoples with African, European, and ...
(Date:12/17/2014)... , Dec. 15, 2014 Research and Markets ... addition of the "Samsung Galaxy S5 - ... report to their offering. ... totally different sensing technology than the iPhone 5S, ... sensor in its product. The Galaxy ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2
... EUGENE, Ore.(Aug. 20, 2007)Nitric acid is a notoriously strong and ... our atmosphere. However, a team of researchers have found that ... top of a water surface. The discovery of the ... the surface of water requires us to re-evaluate how we ...
... of G&D, Drs. Maria Divina Deato and Robert Tjian ... alternative transcriptional core promoter complex directs cell-type specific differentiation ... of transcriptional control of terminal cell differentiation, and will ... date at www.genesdev.org . For nearly 30 ...
... after prior full-dose conventional radiation therapy respond to Boron ... a Phase I/II study at the Helsinki University Hospital, ... Heikki Joensuu, University of Helsinki, considers the results ... field for BNCT, since thus far BNCT has been ...
Cached Biology News:University of Oregon researcher finds that on water's surface, nitric acid is not so tough 2A new radiation therapy treatment developed for head and neck cancer patients 2
(Date:12/24/2014)... “Preparative & Process Chromatography Market ... (Columns, Solvents, Buffers, Valves, Guages, Seals), Accessories, Services, ... Forecasts to 2019” provides a detailed overview of ... trends, and strategies impacting the preparative and process ... of the revenue and share analysis. , ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge ... users and partners of platform upgrades. This ... benefits; empowering users in their quest to ... tools. , According to SoundConnect’s Marketing Manager, ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... mercaptan such as its definition, classification, application ... product specification, manufacturing process, and product cost ... and applications. The analysis also covers upstream ... channels, industry development trend and proposals. In ...
(Date:12/24/2014)... Pipette.com announces their Holiday in ... submit their #HolidayInTheLab pictures for a chance to win ... For those struggling to think of a holiday gift ... the Lab Contest provides the ideal holiday presents. The ... send pictures of their chemistree, holiday sweaters, as well ...
Breaking Biology Technology:Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... , CAMBRIDGE, Mass. , April 28 ... Research Awards Program.  Given annually, the awards will fund ... of diseases and other important human traits. To inaugurate ... interpretation services to three winning research groups, each of ...
... ... browsers enable researchers to quickly and effectively use these invaluable resources. , ... Seattle, WA (PRWEB) April 26, 2010 -- OpenHelix ... on the Overview of Genome Browsers. , , , Ensembl is a genome browser ...
... , LELYSTAD and ,S-HERTOGENBOSCH, The Netherlands ... based biotechnology firm focusing on,protein mimicking technology for the generation of ... therapeutic vaccine,portfolio with Immunovo BV of ,s-Hertogenbosch. Under the terms of ... a,minority interest in Immunovo. , ...
Cached Biology Technology:Knome Announces KnomeDISCOVERY Research Awards Program 2New and Updated Online Tutorials for Ensembl Legacy and Overview of Genome Browsers 2New and Updated Online Tutorials for Ensembl Legacy and Overview of Genome Browsers 3Pepscan Signs Partnering Agreement With Immunovo for its Therapeutic Vaccine Portfolio 2Pepscan Signs Partnering Agreement With Immunovo for its Therapeutic Vaccine Portfolio 3
... versatile enclosures are designed ... or other process gas ... environment. HEPA filtration, heating/cooling, ... modules also available, along ...
... researcher, the new 4300 DNA Analysis System from ... quality of your data. High confidence in more ... LI-COR DNA analysis systems have had for more ... third generation instrument based on LI-CORs highly sensitive ...
... isolation chamber provides a safe, clean ... pharmaceuticals, in accord with USP-797 requirements. ... (ISO 5) cleanliness conditions in the ... rod and tilt-up front panel for ...
... siRNA Tracker Intracellular Localization Kit with ... forward approach to directly label and ... an efficient yet non-destructive manner, for ... and functional inhibition of target gene ...
Biology Products: