Navigation Links
New, automated tool successfully classifies and relates proteins in unprecedented way

a computational strategy for automatically clustering, or grouping, proteins based on SLF similarities and differences. For his study, Murphy used images of randomly chosen, fluorescently labeled proteins. These proteins were produced inside living cells using a technology called CD tagging, which was developed by Jonathan Jarvik and Peter Berget, both associate professors of biological sciences at Carnegie Mellon. The computational analyses were carried out together with Xiang Chen, a graduate student in the Merck Computational Biology and Chemistry program. Chen and Murphy found that the new tool outperformed existing methods of identifying overlapping proteins within cells, such as simple visual categorization of their locations. "Our tool outperformed clustering based on the terms developed by the Gene Ontology Consortium, the best previous way of describing protein location. We found that the Gene Ontology terms were too limited to describe the many complex location patterns we found. Of course, the other drawback of term-based approaches is that they have to be assigned manually by database curators, and this is often not consistent between different curators," said Murphy. Murphy and his colleagues are currently amassing more protein image data using CD Tagging so that they can refine their approach further. They are also working on ways to "train" a general system that will work for different cell types.
'"/>

Source:Carnegie Mellon

Related : Journal of Biomedecine and Biotechnology article


Page: 1 2

Related biology news :

1. Agilent Technologies releases automated literature search tool for biology researchers
2. Biomarkers isolated from saliva successfully predict oral and breast cancer
3. UN successfully tests green pesticide against locusts
4. Stem cell therapy successfully treats heart attack in animals
5. Mad cow proteins successfully detected in blood
6. Israeli scientists successfully transplant frozen-thawed ovaries in sheep
7. Magnetic probe successfully tracks implanted cells in cancer patients
8. UWs Rosetta software to unlock secrets of many human proteins
9. Global analysis of membrane proteins
10. UNC plant researchers discover proteins interact to form hair-trigger protection against invaders
11. Researchers develop new method for facile identification of proteins in bacterial cells
Post Your Comments:
(Date:8/28/2014)... called TX Invasives is now available from the Lady ... at Austin for identifying harmful non-native plant, insect and ... the United States cause about $137 billion in economic ... clog waterways, kill native plants and more. , "By ... reporting where invasive species occur, we,re more likely to ...
(Date:8/28/2014)... America (ESA) is pleased to announce the selection of ... Society. Honorary Membership acknowledges those who have served ESA ... the affairs of the Society that has reached an ... the ESA Governing Board and then voted on by ... the Awards Ceremony at Entomology 2014, ESA,s Annual Meeting ...
(Date:8/28/2014)... have identified a handful of bacterial culprits that may ... and ulcerative colitis, using patients, own intestinal immune responses ... 28 in the journal Cell . , Trillions ... plays a critical role in the development and progression ... number of bacterial species affect a person,s susceptibility to ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Yale study identifies possible bacterial drivers of IBD 2
... conodonts early vertebrates that kept their skeleton in their ... teeth (see image) and, like teeth, they were often worn ... conodonts evolved the first vertebrate dentitions. Scientists know that ... they are microscopic about 2 to 0.2 mm long ...
... A parking lot at the edge of the University ... emerging concern for the environment and human health. ... journal Environmental Science & Technology , has found that ... lots throughout the nation, has significant health and ecosystem implications. ...
... For the first time, scientists at the University of ... progenitor cells using induced pluripotent stem (iPS) cells derived ... retina structures showed the capacity to form layers of ... development and these cells possessed the machinery that ...
Cached Biology News:Size isn't everything -- it's how sharp you are 2UNH research adds to mounting evidence against popular pavement sealcoat 2Scientists produce eye structures from human blood-derived stem cells 2
(Date:8/28/2014)... this month, a report was created by Colorado ... Force on the performance of vehicles using an eco-friendly, ... fuel made from mustard seeds, offered great potential as ... friendly future. In fact, every branch of the U.S. ... foreign oil over the next few years. They will ...
(Date:8/27/2014)... August 27, 2014 Green & Grow ... Series B funding and secured Otter Capital as a ... will accelerate commercialization of GGI’s Agriplier™ technology, building on ... , “Since our first meeting, we have been ... biological product space,” said Alan Sobba, President and CEO ...
(Date:8/27/2014)... how plants survive impact by the huge amounts ... using this energy for photosynthesis. The hypothesis is ... quickly dissipate the energy throughout the entire protein ... Physics have now managed to successfully ,film, this ... light-absorbing proteins which play a role in photosynthesis ...
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
Breaking Biology Technology:Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3DTU researchers film protein quake for the first time 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4
... UCLA today announced the launch of the Mattel ... of personalized medicine for children, including the opportunities ... the world,s first dedicated solely to nanomedicine and ... a nanopediatrics program? Because children are not small ...
... 17 Bunge Limited,(NYSE: BG ), an integrated, ... the quarter ended September 30, 2008, on Thursday,October 23, ... management will host a conference call at 10:00 a.m.,EDT ... To listen to the conference call, please dial ...
... American Society of Anesthesiologists Annual Meeting as Masimo ... Oxygen Content (SpOC) monitor with live ... ... the inventor,of Pulse CO-Oximetry(TM) and Measure-Through-Motion-and-Low-Perfusion pulse,oximetry, announced today that ...
Cached Biology Technology:Mattel Children's Hospital UCLA launches program in nanopediatrics 2Bunge Limited Schedules Third Quarter 2008 Earnings Release and Conference Call 2Five New Clinical Studies Show Value of Masimo PVI & PI 2Five New Clinical Studies Show Value of Masimo PVI & PI 3Five New Clinical Studies Show Value of Masimo PVI & PI 4Five New Clinical Studies Show Value of Masimo PVI & PI 5
Mouse NOV/CCN3 Affinity Purified Polyclonal Ab...
SNARE associated protein snapin, clone MGC:2717...
HiTrap NHS-activated HP, 1 x 5 ml. Category: Chromatography Systems & Accessories, Systems....
Human Serpin A8/AGT Affinity Purified Polyclonal Ab Keywords: Ang II, AngII, Hypertension, Salt Homeostasis, Pre-eclampsia...
Biology Products: