Navigation Links
Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

Nerves talk to each other using chemicals called neurotransmitters. One of those "communication chemicals," aptly named GABA (gamma amino butyric acid), shows up in unusually high amounts in some aggressive tumors, according to a new study from Washington University School of Medicine in St. Louis.

The researchers investigated metastatic neuroendocrine tumors, which include aggressive types of lung, thyroid, and prostate cancers that spread to other parts of the body. Their study will appear in the July 12 issue of the Proceedings of the National Academy of Sciences and is available online after July 4.

"GABA appears to be an indicator of a bad prognosis for these cancers," says Jeffrey I. Gordon, M.D., director of the Center for Genome Sciences at Washington University. "But there's hope in our ability to identify substances, like GABA, that are associated with metastatic tumors. Usually these tumors are diagnosed only after they have spread to other parts of the body, but now we have the potential to recognize them before they metastasize."

Elevated amounts of GABA were discovered in an analysis of aggressive neuroendocrine prostate tumors in genetically engineered mice. Along with GABA, two other substances were seen, one a related neurotransmitter and the other a plant growth hormone with an unknown function in animals. Furthermore, the researchers found that the tumors made GABA using a different set of biochemical reactions than normal. Key enzymes involved in the production of these compounds were switched on in poor prognosis malignant metastatic tumors.

"The mouse model was an important beginning point for our investigation," says the study's lead author Joseph E. Ippolito, a graduate research assistant in the University's NIH-supported Medical Scientist Training Program. "We took information about what genes were expressed in the mouse tumors, made computer-assisted predictions about what type of metabolism was going on in th
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Plants respond similarly to signals from friends, enemies
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Viral protein influences key cell-signaling pathway
4. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
5. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
6. Scientists discover that three overlapping signals in embryo help get the backbone right
7. After a time-shift, mixed signals from the circadian clock
8. Researchers make surprise discovery that some neurons can transmit three signals at once
9. Structure-building cell signals also may influence learning and memory
10. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
11. Immune systems distress signal tells bacteria when to strike back
Post Your Comments:
(Date:4/27/2015)... 2015 Profile Solutions, Inc. (OTC: PSIQ), a ... is pleased to announce that Dr Gerry Bedore ... member of its scientific advisory board. ... thought leader in technology-enhanced learning models. He was a ... published studies and books focused on online student success ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. today ... (FIDO ® ) Alliance tm , an industry ... members commit to share technology and collaborate to ... are interoperable, more secure and private, and easier ... identity verification that protects sensitive user information and ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... 23, 2015, after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
Breaking Biology News(10 mins):Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Synaptics to Report Third Quarter Results on April 23 2
... new energy-efficient approach to building occupancy detection, a better ... a high-efficiency silicon solar cell all developed or ... (NREL) have been named among this year,s most ... awards honoring our work in solar, vehicles and energy ...
... DUBLIN, Ireland , July 9, 2013 ... ) has announced the addition of the ... Report" report to their offering. ... the worldwide markets for Face and Voice Biometrics ...
... July 8, 2013 /PRNewswire-iReach/ -- Jade Holding Group, LLC dba ... surgery and wellness centers, has just added a new page ... procedure. In addition, Tickle Lipo has proven to be so ... special pricing for the procedure. (Photo: http://photos.prnewswire.com/prnh/20130708/CG43414 ...
Cached Biology News:NREL research earns 3 prestigious R&D 100 Awards 2NREL research earns 3 prestigious R&D 100 Awards 3NREL research earns 3 prestigious R&D 100 Awards 4Face and Voice Biometrics - Global Strategic Business Report 2Face and Voice Biometrics - Global Strategic Business Report 3Face and Voice Biometrics - Global Strategic Business Report 4Strax Rejuvenation Adds New Page to Website Devoted to Tickle Lipo Procedure 2
(Date:5/20/2015)... , May 20, 2015  Select Medical ... the Federal Trade Commission granted early termination of ... Improvements Act of 1976, as amended, applicable to ... Acquisition Corporation, a joint venture that Select has ... As previously announced, MJ Acquisition Corporation ...
(Date:5/20/2015)... May 20, 2015 Agricultural firm H.J. ... of its acquisition of Tiger-Sul. Since the purchase ... Alberta, Canada) in May 2005, H.J. Baker has leveraged ... it into a comprehensive portfolio of product offerings and ... H.J. Baker and the innovation of Tiger-Sul, transforming the ...
(Date:5/20/2015)... , May 20, 2015  Cypher Genomics, Inc., ... collaboration with Celgene Corporation to apply Cypher,s Coral ... that associate with patient response to innovative medicines. ... to help accelerate patient access to the right ... clinical research and development and potentially inform new ...
(Date:5/20/2015)... Carolina , 20. Mai 2015 ... für klinische Logistik (Clinical Logistics Organization/CLO) ... Geschäftsjahr 2014, das am 31. Dezember ... Unternehmen hat die Marktentwicklung übertroffen und ... - http://photos.prnewswire.com/prnh/20110930/NY78064LOGO ...
Breaking Biology Technology:Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... Madison, Wis. - TomoTherapy saw its revenues ... $131.1 million, according to the first earnings report ... ,The company also announced that it has joined a research ... produce a lower-cost proton therapy system for cancer treatment. , ...
... Vista/Office 2007 learning curve for the last two weeks, ... basement. Frustration has reached all-time highs, and all I'm trying ... a presentation, and review a financial spreadsheet. , ,It's the ... I got a new laptop. My three-year old ThinkPad ...
... of this series on e-discovery, we discussed the ... require parties to address and resolve issues regarding the ... of attack or a system of satisfying your obligation ... your company at risk. This article discusses how ...
Cached Biology Technology:TomoTherapy reports 86% revenue jump, $131M net loss in Q1 2TomoTherapy reports 86% revenue jump, $131M net loss in Q1 3Picking Vista sure seemed like a good idea at the time 2Picking Vista sure seemed like a good idea at the time 3Finding Safe Harbor in a sea of electronic discovery 2Finding Safe Harbor in a sea of electronic discovery 3
... in the evolution of laboratory automation. A ... labware to multiple laboratory instruments, LabLinx gives ... of ordinary microplate robots. It allows the ... to meet any labs specific automation needs, ...
... applications for the use of small interfering ... via the RNA interference (RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... or enzymatically, and then transfected into the ...
... Array Service enables scientists who have access to ... FAST Slides printed with proteins from S&Ss antibody ... the arrays is performed by the customer. Its ... discuss your needs with an expert and define ...
... The high-performance triple quadrupole 1200L ... in today's cost-conscious environment - incorporating ... solutions for all liquid chromatography analytical ... (API) interface and the Transmission Quadrupole ...
Biology Products: