Navigation Links
Neuronal 'traffic jam' marks early Alzheimer's disease

nection between the transport deficit and plaque deposition.

"So, our hypothesis is that in familial Alzheimer's disease -- or in disorders such as Down syndrome where beta-APP is overexpressed -- those defects cause early failure in cellular transport," he said. "And those failures then stimulate further production of A-beta peptide, which may further poison the machinery."

Goldstein theorized that Alzheimer's disease might develop spontaneously in people without an overt genetic defect, as the transport machinery in their neurons breaks down with age. "A person could have a predisposition to the disease, or it could just be that as time progresses, one person could by chance accumulate these blockages more than another," said Goldstein. "And randomly, some people would accumulate more than others, enough to cross a critical threshold and tip the scale toward disease."

Goldstein emphasized that any application of these findings to potential diagnostic tests or new therapies remains speculative at this time. "However, if tracers could be developed that would reflect transport function, there could be imaging methods that might be helpful for diagnosis," he said. "And, if these findings continue to hold for humans, the transport machinery could be a target for drugs to preserve that machinery."

The researchers plan to continue their exploration of the transport machinery's involvement in Alzheimer's pathology by using human embryonic stem cells to differentiate into neurons in culture. Their goal is to alter those neurons genetically by introducing mutations know to cause Alzheimer's disease in people, to then test for transport defects, and then study whether those defects produce pathology similar to that seen in Alzheimer's. One of the questions they will also ask is whether amyloid plaques poison the transport machinery. If the experiments do, indeed, confirm the predictions of the transport hypothesis, then neuronal cultures could
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Molecular Partners Required For Appropriate Neuronal Gene Repression
2. Neuronal cell cultures kept on the straight and narrow
3. Discovery of T-cell traffic control boosts new drug promise
4. A traffic light for neurons means go for improving brain research
5. New gene scanning technology marks a major advance in disease research
6. Novel molecular signature marks DNA of embryonic stem cells
7. Scientists map key landmarks in human genome
8. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. In the migratory marathon, parasitized monarchs drop out early
11. Test for early detection of prostate cancer shows promise
Post Your Comments:
(Date:12/3/2009)..., , Spanish researchers have measured CO2 levels ... atmosphere) over a sparsely inhabited rural area ...of their kind in the Iberian Peninsula, show that ...005. , Over recent years, physicists and meteoro...dioxide (CO2) levels, and how these have evolved i...
(Date:12/3/2009)..., The 30-year record low in Antarctic snowmelt th...likely due to concurrent strong positive phases fo...n Oscillation) and SAM (Southern Hemisphere Annula... Professor of Earth & Atmospheric Sciences at The ... who is also on the doctoral faculty at the CUNY G...
(Date:12/2/2009)..., , PHILADELPHIA New study results strengthen th... long period of time have an increased risk for de...or other risk factors. , "This provides one mor...ble," said senior author Michael J. Thun, M.D., M....eillance research at the American Cancer Society. ...
Breaking Biology News(10 mins):CO2 levels rising in troposphere over rural areas 2CCNY professor foresees rising Antarctic snowmelt 2Cigarette smoking increases colorectal cancer risk 2US Government Places 6 1 Million USD Orders Related to Precise Match on Card 28TM 29 for Cyber Security Programs 9217 1US Government Places 6 1 Million USD Orders Related to Precise Match on Card 28TM 29 for Cyber Security Programs 9217 2Type of Knee Surgery Makes Difference in Football Career 51400 1Type of Knee Surgery Makes Difference in Football Career 51400 2Obama 3A Too Many Still Die from Diseases That Shouldnt Kill Them 51397 1Obama 3A Too Many Still Die from Diseases That Shouldnt Kill Them 51397 2
...genome or the egg genome? , Researchers have answ...nomic question: Which of the thousands of long str...rst? And which are the duplicates? , The answers,...7, 2007, provide the first evolutionary history of...tly responsible for both disease and recent geneti...
... Capecchi, Ph.D., distinguished professor of human...ccles Institute of Human Genetics and a Howard Hug...07 Nobel Prize in Physiology or Medicine. , The a...embly at the Karolinska Institute, in Stockholm, S...evelopment of knockout mice technology, a gene-tar...
...nati (UC) radiologists have developed a new techni... diagnosis of venous diseases. , Multi-detector c... used to create three-dimensional images of arteri... from the heart and distribute blood throughout th...o the heart, are more difficult to accurately imag...
Other Biology News:Which came first, the chicken genome or the egg genome? 2Which came first, the chicken genome or the egg genome? 3Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine 2Gene-targeting pioneer Mario Capecchi shares 2007 Nobel Prize in Medicine 3New thoracic imaging approach can pinpoint underlying venous problems 2
(Date:12/3/2009)...Newswire-FirstCall/ -- VIA Pharmaceuticals, Inc. (...n the development of compounds for the treatment o...unced that it has completed the last patient visit.... ,, The FDG-PET trial enrolled 52 patients an...da including Massachusetts General Hospital, Mount...
(Date:12/3/2009)...RNewswire-FirstCall/ -- Inverness Medical Innovati...ing individuals to take charge of their health at ...ealth management, has declared a dividend of $3.00...referred Stock ( IMA-PB). The dividend will be pai...re equal to the quotient of (a) $3.00 divided by (...
(Date:12/2/2009)...RNewswire-FirstCall/ -- Martek Biosciences Corpora...nds to release the results of its fourth quarter a...ximately 4:00 p.m. Eastern Time (ET). Following t...conference call to discuss these results with inve...all live via webcast by visiting Martek,s web site...
(Date:12/2/2009)...RNewswire/ -- Reportlinker.com announces that a ne...ogue: ,, Carbondioxide Incubators - A Global M...com/p0164368/Carbondioxide-Incubators---A-Global-M...most critical equipment used in microbiology, gene... providing a controlled environment to grow and st...
Breaking Biology Technology:VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 2VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 3VIA Pharmaceuticals Completes Patient Visits in Phase 2 Trial of VIA-2291 4Martek to Announce Fourth Quarter and Fiscal Year 2009 Results 2Reportlinker Adds Carbondioxide Incubators - A Global Market Perspective 2Reportlinker Adds Carbondioxide Incubators - A Global Market Perspective 3Reportlinker Adds Carbondioxide Incubators - A Global Market Perspective 4
...an Technology and Global Business Potential, SOUT... a,leading algal biotechnology company, today anno... of the GoingGreen 100 Top Private Companies for,2...s compiled by the,AlwaysOn editorial panel. In ord...panies had to be peer-nominated, with AlwaysOn rec...
...ation,s obesity crisis by addressing gen...SAN DIEGO, Sept. 11 Salugen, Inc., a personalized... of GenoTrim, a DNA-based,nutritional solution for...,weight through both standard weight reduction str...essful for the 58 million overweight,individuals i...
...11 /PRNewswire-FirstCall/ - MIGENIX,Inc. (TSX: MGI... for,infectious diseases, reports financial result...update on its programs. UPDATE ON DRUG DEVELOPMEN...X-226; topical cationic peptide;,prevention of cat...dy is in,progress in the United States under a Spe...
Other Biology Technology:Solazyme, Inc. Selected by AlwaysOn as a GoingGreen 100 Top Private Company Award Winner 2Solazyme, Inc. Selected by AlwaysOn as a GoingGreen 100 Top Private Company Award Winner 3Salugen Announces the U.S. Launch of GenoTrim - a DNA Customized Nutritional Solution for Weight Management 2Salugen Announces the U.S. Launch of GenoTrim - a DNA Customized Nutritional Solution for Weight Management 3MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 2MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 3MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 4MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 5MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 6MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 7MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 8MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 9MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 10MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 11MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 12MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 13MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 14MIGENIX Reports First Quarter Fiscal Year 2008 Financial Results 15
Goat Anti-Human PLUNC Polyclonal Antibody, Biotin Conjugated from R&D Systems
Mouse Anti-Human RXR beta / NR2B2 Monoclonal Antibody, Unconjugated, Clone H7341 from R&D Systems
Rabbit Anti-GRASP1 Polyclonal Antibody, Unconjugated from Abcam
Porcine Galanin , 3-[125I]iodotyrosyl26 Conjugated/Tagged from GE Healthcare, formerly Amersham Biosciences
Biology Products: