Navigation Links
Neuronal 'traffic jam' marks early Alzheimer's disease

Early Alzheimer's disease may be precipitated by a "traffic jam" within neurons that causes swelling and prevents proper transport of proteins and structures in the cells, according to new studies by Howard Hughes Medical Institute researchers.

In mouse models of Alzheimer's disease and in human brain samples from people with the disease, researchers observed a characteristic breakdown in neurons that appears to prevent the normal movement of critical proteins to the communications centers of the nerve cells. In a vicious cycle, the traffic jam also could increase production of an abnormal protein that clogs neurons, leading to their failure and eventual death.

The researchers said their findings could provide information that might be used to develop drugs to preserve the molecular transport system and thus the viability of brain cells otherwise lost in Alzheimer's. The findings also could ultimately lead to distinctive markers of early Alzheimer's disease that could be used in early diagnostic tests for the disorder, they said.

The research team led by Lawrence S. B. Goldstein, a Howard Hughes Medical Institute investigator at the University of California, San Diego (UCSD), reported their findings in the February 25, 2005, issue of the journal Science. Goldstein and his colleagues at UCSD collaborated on the studies with a researcher at the Albert Einstein College of Medicine.

According to Goldstein, there has been evidence that late-stage Alzheimer's disease involves a failure of the machinery that transports proteins within neurons. In studies with fruit flies, Goldstein and others had observed that overexpression of the gene for a key protein that underlies Alzheimer's pathology, called beta amyloid precursor protein (beta-APP), triggers defects in axonal transport. A defective version of beta-APP is cleaved to form an aberrant form of amyloid beta (A-beta) peptide that makes up the plaques that surround the neurons of people with
'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4

Related biology news :

1. Molecular Partners Required For Appropriate Neuronal Gene Repression
2. Neuronal cell cultures kept on the straight and narrow
3. Discovery of T-cell traffic control boosts new drug promise
4. A traffic light for neurons means go for improving brain research
5. New gene scanning technology marks a major advance in disease research
6. Novel molecular signature marks DNA of embryonic stem cells
7. Scientists map key landmarks in human genome
8. UCSB scientists probe sea floor venting to gain understanding of early life on Earth
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. In the migratory marathon, parasitized monarchs drop out early
11. Test for early detection of prostate cancer shows promise
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Neuronal traffic jam marks early Alzheimer disease

(Date:5/17/2013)... An international team of scientists using ... cell movement inside a living frog embryo in greater ... method to advance biological research and the search for ... and the Karlsruher Institut fr Technologie in Germany, in ... Department of Energy,s Argonne National Laboratory, released the most ...
(Date:5/16/2013)... have used ancient shorelines to predict the stability of today,s ... high shoreline from three million years ago, for example ... thought to be evidence of a high sea level due ... led many scientists to think that if the world,s largest ... just the same in our modern, progressively warming world. ...
(Date:5/16/2013)... players and athletes choose to wear the color red ... in Psychological Science , a journal of the ... to do with their testosterone levels. , The new ... University of Sunderland and colleagues, demonstrated that males who ... had higher testosterone levels than other males who chose ...
Breaking Biology News(10 mins):New X-ray method shows how frog embryos could help thwart disease 2World's biggest ice sheets likely more stable than previously believed 2High-testosterone competitors more likely to choose red 2
... a baby is usually a joyous event, but when a child ... problems for the baby and steep medical bills for the family. ... have invented a new system to pick up very early signs ... normal length of a pregnancy is 40 weeks, while babies born ...
... -- Can HIV infection ever be cured? The prospect ... the topic of a high-level, two-day meeting of researchers ... biennial international conference of HIV researchers, funders, policy-makers and ... and Strategies to Control Them," brought together basic scientists, ...
... have provided a new solution to an old debate on why ... study to be published online next week in the online open ... of genetic "noise" caused by a surprising degree of variation in ... They found that when species hybridise, some of the variation in ...
Cached Biology News:Students design early labor detector to prevent premature births 2Students design early labor detector to prevent premature births 3Students design early labor detector to prevent premature births 4Top scientists tackle the issue of HIV persistence 2What causes hybrid vigor? 2
(Date:5/17/2013)... 17, 2013 The new Public-Private Partnership ... at the association’s recent annual meeting drew praise from ... Neelie Kroes, who called the action “a huge step ... stimulant to European innovation.” , The Board of Stakeholders ... new Photonics PPP at its 29 April meeting in ...
(Date:5/17/2013)... ALTO, Calif. , May 17, 2013 /PRNewswire/ ... it has achieved 50% enrollment of the total ... to evaluate the safety and preliminary efficacy of ... Cells) therapy for Knee Osteoarthritis (KOA). To date ... (SAE) reported. The Phase I open ...
(Date:5/17/2013)... , May 17, 2013  Insero Health, Inc., ... needs in epilepsy and related neurological disorders, is today ... its lead compound INS001 in patients with drug-resistant epilepsy.  ... and Device Trials (AED) Xll meeting by Dr. ... and Chairman of Insero,s Scientific Advisory Board.  In this ...
(Date:5/17/2013)... RURO Inc. is pleased to ... versatile refinement to the smart management solution. , ... advanced methodical management for transgenic animal colonies, genotyping ... network-based platform provides user access with a plethora ... to emphasize streamlined tasks, such as animal relocation ...
Breaking Biology Technology:SPIE Joins in Praise for ‘Huge Step Forward’ for Innovation R&D Enabled by Photonics21 Actions 2SPIE Joins in Praise for ‘Huge Step Forward’ for Innovation R&D Enabled by Photonics21 Actions 3Cellular Biomedicine Group Achieves 50% Enrollment Milestone in Phase I Clinical Trial for Knee Osteoarthritis 2Insero Health Reports Positive Data on Phase I Trial of Novel Therapy for Drug-resistant Epilepsy 2RURO Introduces ezColony 4.1 – The Versatile Transgenic Animal Colony Management Software 2
... VIEW, Calif., May 5 ChemoCentryx, Inc., today ... small molecule antagonist of the C5a receptor, CCX168, ... acceptance of the molecule as a development candidate ... alliance with GlaxoSmithKline (NYSE: GSK ). ...
... May 5 UV germicidal lamps have been used ... airborne respiratory illnesses in schools and hospitals since the ... in Mexican schools during a 1955 Mumps epidemic and ... York that same year. More recently, UVGI units were ...
... Technologies & Bioressources Inc. ("Neptune") (NASDAQ.NEPT - TSX.V.NTB) provides an ... Worldwide Sales and Distribution Update, - ... of two, additional marketing and ... recognized backgrounds in the nutraceutical and functional food, ...
Cached Biology Technology:ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist 2ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist 3ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist 4Swine Flu Fears Generate Interest in UV Disinfection Technologies...Again 2Neptune Product and Distribution Update 2Neptune Product and Distribution Update 3Neptune Product and Distribution Update 4
This free-standing laminar flow hood provides a horizontal flow of HEPA-filtered air to create a clean processing area. Air return slots along the front and side edges of the work area enhance system...
... B3 series of microscopes offer all of ... for laboratory work. Equipped with Koehler illumination, ... (ASC) objectives. The B3 is the workhorse ... binocular tube eliminates the need for re-focusing ...
... control for microbiology and cell culture. The ... suitable for DASGIP bioreactors from 150 mL ... ranges from approximately 10 °C to 60 ... an individual electrical heating element with integrated ...
RORgamma (S-14)...
Biology Products: