Navigation Links
Neurologix announces positive results of gene therapy clinical trial in Parkinson's disease

Investigators report safety findings and statistically significant improvements in clinical measures of movement, PET Scans at 19th Annual Symposia on the Etiology, Pathogenesis and Treatment of Parkinson's Disease and Other Movement DisordersNeurologix's Phase I trial showed positive interim results in patients with Parkinson's disease. One year following treatment, patients exhibited a statistically significant improvement in motor function on the side of their body correlating to the treated part of the brain. Further, PET scans at one year revealed that the treated side of the brain exhibited a statistically significant decrease in abnormal metabolism, results considered similar to those achieved with STN Deep Brain Stimulation.

FORT LEE, N.J., Sept. 26, 2005 -- Neurologix, Inc. (OTCBB:NRGX) today announced positive interim results of its landmark gene therapy clinical trial for patients with Parkinson's disease. Neurologix's 12-patient, dose-escalating Phase I trial is the world's first study to use a viral vector (the non-pathogenic adeno-associated virus, or AAV) for the treatment of an adult neurological disease. In the Neurologix-funded trial, the vector was injected into a specific target site in the brain in order to transfer a gene to treat Parkinson's disease. The gene encodes glutamic acid decarboxylase (GAD), an enzyme which synthesizes the major inhibitory neurotransmitter in the brain, (gamma)-aminobutyric acid (GABA).

Under the FDA-sanctioned trial protocol, patients with advanced Parkinson's disease received unilateral (one side of the brain) infusion of AAV-GAD via a hair-thin catheter into the subthalamic nucleus (STN), a deep brain structure known to function abnormally in Parkinson's patients. According to the interim findings, Neurologix's STN AAV-GAD treatment appears to be safe and well-tolerated in advanced Parkinson's disease, with no evidence of adverse effects or immunologic reaction related to the study treatment.
'"/>

Source:jjackson@burnsmc.com


Page: 1 2 3 4 5 6

Related biology news :

1. Wiley announces publication of Databasing the Brain
2. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
3. Eisai announces Phase II data on E7389, a potential new therapy for the treatment of breast cancer
4. GlycoFi announces the first production of antibodies with human glycosylation in yeast
5. NHGRI announces new sequencing targets
6. CHAVI announces international search for genes affecting HIV response
7. NHGRI announces latest sequencing targets
8. MUHC announces a transplant first in Quebec
9. St. Jude announces breakthrough in eye cancer treatment
10. NIH announces phase III clinical trial of creatine for Parkinsons disease
11. Insight into the processes of positive and negative learners

Post Your Comments:
(Date:11/23/2009)...e is available in German . , Not just birds...ey every year. Researchers at Princeton University...rnithology in Radolfzell, Germany studied the migr...ts, the so-called "Vespertilionidae" with the help...migration over short as well as long distances of ...
(Date:11/22/2009)...- Children exposed prenatally to tobacco smoke and... risk for ADHD, according to research done at Cinc... study estimates that up to 35 percent of ADHD cas...be reduced by eliminating both of these environmen...,000 children , "Tobacco and lead exposure each...
(Date:11/22/2009)...Marine Life scientists have inventoried an astonis... sea species that have never known sunlight - crea...ck world down to 5,000 meters (~3 miles) below the..., sonar and other vanguard technologies, animals k...umber 17,650, a diverse collection of species rang...
Breaking Biology News(10 mins):We're off then: The evolution of bat migration 2Exposure to lead, tobacco smoke raises risk of ADHD 2Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 2Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 3Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 4Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 5Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 6Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 7Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 8Beyond sunlight: Explorers census 17,650 ocean species between edge of darkness and black abyss 9Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 1Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 2Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 3Dean MacCarter Ph D Addressed Differentiation of Responder vs Non Responder CRT Status with Low Level Exercise at HFSA13th Annual Scientific Meeting 57454 4Baylor Health Care System Named Among 2009 Best Places to Work in Healthcare 57451 1Baylor Health Care System Named Among 2009 Best Places to Work in Healthcare 57451 2Veteran Intellectual Property Team Joins Brown Rudnick 14113 1Veteran Intellectual Property Team Joins Brown Rudnick 14113 2
...aunching Tropical Plant Biology, a journal which w...of tropical plant biology as well as applications ...ropical Plant Biology joins the growing number of ... portfolio. The first issue is scheduled for Marc...ost rapidly advancing aspects of tropical plant bi...
...y into variation and evolution of reproductive sys... ground-breaking work within the plant sciences. ... Plant Sciences, leading botanist Spencer Barrett ... single volume some of the most compelling work on...lowers and pollination, mating patterns and gender...
...-in-Chief of Experimental Biology and Medicine (EB...or expansion of the journal and enhancement of the... and Medicine (SEBM) into Asia. The plan, which i... bringing outstanding Asian researchers onto the E...amongst the leaders in Asian Biomedical Science, a...
Other Biology News:Springer launches Tropical Plant Biology 2A special issue of the International Journal of Plant Sciences 2A special issue of the International Journal of Plant Sciences 3Experimental Biology and Medicine announces expansion into Asia, opens new office 2Experimental Biology and Medicine announces expansion into Asia, opens new office 3
(Date:11/23/2009)...romises ultra-fast communication, computation and ...n. But trying to use quantum states as carriers of...w two physicists have shown, mathematically, how t...nication, while keeping the information intact. Th...ical Review Letters and highlighted with a Viewpo...
(Date:11/23/2009)...E,Nev.,Nov.23/PRNewswire-FirstCall/--PDLBioPharma,...sestablishedNovember27,2009astheex-dividenddatefor...ngfromthesecuritizationtransactioncompletedonNovem...allstockholdersofrecordontherecorddate,December1,2...ividendat$1.67pershareofcommonstockforpurposesofth...
(Date:11/23/2009)...,Nov.23/PRNewswire-FirstCall/--NeogenCorporation(N....D.,waselectedtoNeogen,sBoardofDirectorsatthecompa...erhasmorethan40yearsofexperienceinthefood,agricult...tprofessorofagriculturaleconomicsatVirginiaTechUni...edStateschiefagriculturenegotiatorwiththerankofamb...
(Date:11/23/2009)...3/PRNewswire/--ImmuneDesignC or p.(IDC)announcedto...airman.Dr.Carterhasasuccessfultrackrec or dinbiote...xecutiveOfficeratZymoGenetics,inSeattle,WAandChief...k. ,, (Photo: http://www.newscom.com/cgi-bin/pr...nderandChiefExecutiveOfficercommented,"Iamdelighte...
Breaking Biology Technology:PDL BioPharma Announces Ex-Dividend Date of November 27 for Special Dividend 2Richard T. Crowder Joins Neogen's Board of Directors 2Immune Design Corp. Announces Appointment of Dr. Bruce L.A. Carter as Executive Chairman and Director 2
... a brain cancer death sentence. , ,Of the approxim...ually in the U.S., half will die within a year, an...t stretch survival limits are exceptionally invasi...atment with the maximum tolerated dose - all of wh...use of this, researchers are racing to find better...
...n-Madison continues to make stem-cell advances , ...ounced over the weekend, things aren,t going so we...Hwang Woo-suk, a South Korean stem-cell researcher...ns surfaced that he fabricated stem-cell research ...m were merely that he knew a colleague, Roh Sung-i...
...! I sit hear writing this article as I listen, app..."Cream Gold" (released in 2005 - not to be confuse...Cream, you may ask? Well, the successful re-emerge...certs held in London and NewYork,s Madison Square ...by-boomer. I caught a part of these concerts on pu...
Other Biology Technology:Radiology advance points way to non-invasive brain-cancer treatment 2Stem-cell controversies slow progress 2Biotech flourishes in 2005 while Big Pharma is on the decline 2Biotech flourishes in 2005 while Big Pharma is on the decline 3Biotech flourishes in 2005 while Big Pharma is on the decline 4Biotech flourishes in 2005 while Big Pharma is on the decline 5Biotech flourishes in 2005 while Big Pharma is on the decline 6Biotech flourishes in 2005 while Big Pharma is on the decline 7Biotech flourishes in 2005 while Big Pharma is on the decline 8
Bovine TNP-BGG (Bovine Gamma Globulin), BGG (Bovine Gamma Globulin) conjugated/tagged from Biosearch Technologies
ELISpot Blue Color Module (Strep-AP and BCIP-NBT) from R&D Systems
...aBEAD Mouse CD4, polyclonal Sheep anti-Mouse Fab t...CD4 (L3T4). Detach positively isolated mosue CD4+...D Mouse CD4. The isolated cells are suitable for a..., functional studies and expansion using the Dynab...
Canine IL-10 ELISpot Development Kit from R&D Systems
Biology Products: