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Neural stem cells lend the brain a surprising capacity for self-repair

umblike have two important functions, namely a role in the survival of neuroblasts and an unexpected role in maintaining the cellular wall that lines the ventricular region of the brain in which the SVZ resides. Without the normal complement of genes, that wall "disintegrated," he said, leaving holes in the brain.

Surprisingly, they reported, the ventricular damage was eventually repaired. SVZ reconstitution and remodeling of the ventricular wall was driven by progenitor cells that escaped Numb deletion, they found.

"Although the exact mechanisms are still being worked upon, these observations raise the possibility that postnatal neurogenesis can one day be used to repair brain damage," the researchers concluded.

"Our results here show that self-repair and local remodeling can indeed happen along the brain's lateral ventricular wall, and further insights into this process should shed light on whether SVZ neural stem cells participate in stroke/trauma-induced brain remodeling and postnatal/adult brain tumor formation. Furthermore, understanding how the SVZ cells participate in local repair should help bring us closer to the goal of using neural stem cells as therapeutic agents in neurodegenerative diseases."


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Source:Cell Press


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