Navigation Links
Neural stem cells lend the brain a surprising capacity for self-repair

The brain contains stem cells with a surprising capacity for repair, researchers report in the December 15 issue of the journal Cell, published by Cell Press. The novel insight into the brain's natural ability to heal might ultimately have clinical implications for the treatment of brain damage, according to the researchers.

The researchers found that mice whose brains were severely damaged by loss of the genes "Numb" and "Numblike" in one region just after birth showed substantial mending within weeks. They attributed that repair to neural stem cell "escapees" that had somehow retained or restored the genes' activity and, with it, their regenerative potential.

"At two weeks, the knockout animals' brains had developed a big hole," said Yuh-Nung Jan, a Howard Hughes Medical Institute investigator at the University of California, San Francisco. "We thought that the mice would not live long, but by four weeks, the hole was largely repaired and the animals survived.

"It was a big surprise. It was not known that the brain has this kind of ability to repair itself."

Jan and his colleagues first discovered Numb in the fruit fly Drosophila more than 10 years ago. The gene was found by them and others to play a role in determining the fate of neuroblasts, cells that develop into neurons or other support cells in the insects' brains. Later, researchers found two functionally related mammalian proteins, dubbed Numb and Numblike, to be critical in the development of neurons in embryonic mice.

To investigate the genes' role after birth, Jan's team developed mice in which Numb and Numblike could be turned off only in a portion of the brain termed the subventricular zone (SVZ) when they administered a particular drug. The SVZ is known to be a site, or niche, that contains neural stem cells after birth.

In newborn mice, loss of the genes left the SVZ "greatly disturbed," Jan said.

Their results indicated that Numb and N
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Neural stem cell gene plays crucial role in eye development
2. Neural networking nanotubes
3. Neural bottleneck found that thwarts multi-tasking
4. Wisconsin scientists grow critical nerve cells
5. Spleen may be source of versatile stem cells
6. Researchers discover way to make cells in the eye sensitive to light
7. Priming embryonic stem cells to fulfill their promise
8. Lack of enzyme turns fat cells into fat burners
9. Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
10. Elusive HIV shape change revealed; Key clue to how virus infects cells
11. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Neural stem cells lend the brain surprising capacity for self repair

(Date:8/4/2015)... 2015 Research ... the addition of the "Digital Forensics ... Sub-Segment (Computer Forensics, Network Forensics, Mobile Device ... Vertical and Region - Global Forecast to ... By Component (Hardware, Software, and Service), ...
(Date:8/4/2015)... ) today reported financial and operating results for the second quarter ... quarter contract revenue of $ 85.2 million, a ... of 26 % , Second quarter adjusted ... royalties in the current quarter , Operating cash ... to present another strong financial quarter, with all our divisions achieving ...
(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. (Nasdaq: ... solutions, today announced that members of the executive management ... Pacific Crest Global Technology Leadership Forum on Tuesday, August ... will be held at the Sonnenalp Resort in ... presentation may include forward-looking information. An audio webcast of ...
Breaking Biology News(10 mins):Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2AMRI Announces Second Quarter 2015 Results 2AMRI Announces Second Quarter 2015 Results 3AMRI Announces Second Quarter 2015 Results 4AMRI Announces Second Quarter 2015 Results 5AMRI Announces Second Quarter 2015 Results 6AMRI Announces Second Quarter 2015 Results 7AMRI Announces Second Quarter 2015 Results 8AMRI Announces Second Quarter 2015 Results 9AMRI Announces Second Quarter 2015 Results 10AMRI Announces Second Quarter 2015 Results 11AMRI Announces Second Quarter 2015 Results 12AMRI Announces Second Quarter 2015 Results 13AMRI Announces Second Quarter 2015 Results 14AMRI Announces Second Quarter 2015 Results 15AMRI Announces Second Quarter 2015 Results 16AMRI Announces Second Quarter 2015 Results 17AMRI Announces Second Quarter 2015 Results 18AMRI Announces Second Quarter 2015 Results 19AMRI Announces Second Quarter 2015 Results 20AMRI Announces Second Quarter 2015 Results 21AMRI Announces Second Quarter 2015 Results 22AMRI Announces Second Quarter 2015 Results 23AMRI Announces Second Quarter 2015 Results 24
... of the most common pathological changes after epileptic ... considered to be closely related with temporal lobe ... or synaptic remodeling in hippocampal CA3 pyramidal cells, ... synaptic circuits, thereby increasing epileptic susceptibility. Exogenous neuropeptide ...
... JoVE, the Journal of Visualized Experiments will publish ... the genes that govern food-related behavior in honey bees. ... closer toward understanding and perhaps changing undesirable ... technique has already helped to unravel [the] complex gene ...
... The science-based management and governance of shared transboundary water ... articles now published in a special edition of the ... of the Global Environmental Facility,s IW:LEARN project and the ... the special open-access volume includes a treasury of articles ...
Cached Biology News:Honey bee gene targeting offers system to understand food-related behavior 2Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 2Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 3Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 4Managing waters shared across national boundaries: Treasury of papers helps capture 20 years of lessons 5
(Date:8/3/2015)... DIEGO , Aug. 3, 2015  Halozyme Therapeutics, ... Update Conference Call for the second quarter 2015 on ... PT. Dr. Helen Torley , president and chief ... date post-market, Halozyme will release financial results for the ... webcast live through the "Investors" section of Halozyme,s corporate ...
(Date:8/3/2015)... ... 03, 2015 , ... The synthetic rubber industry is recognized ... as ethylbenzene, a precursor to styrene, used to make styrene-butadiene resins, styrene butadiene ... production of tyres and other components. Thus, growth in the automotive industry is ...
(Date:8/3/2015)... 3, 2015 E-QURE Corp. (OTCQB: ... its Bio-electrical Signal Therapy device ("BST Device"), a new ... to heal chronic wounds, today announced that the Company ... Israeli distributor specializing in medical devices, for the marketing ... is a 70 years old, sales, marketing and distribution ...
(Date:8/3/2015)... ... August 03, 2015 , ... Sterlitech Corporation introduces the compact, ... of analytical laboratory equipment. With optimized features, such as PTFE-coated contact surfaces, an ... and maintenance-free solution for a broad range of vacuum filtration applications. , Featuring ...
Breaking Biology Technology:Halozyme to Host Second Quarter 2015 Financial Results Conference Call 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 2World Benzene Market to Surpass 46 MMT by 2020, According to TechSci Research Report Published at MarketPublishers.com 3E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Sterlitech Launches New Line of Vacuum Pumps 2
... Bioscience announced today that it has been awarded ... from the United,States Defense Threat Reduction Agency (DTRA) ... a broad spectrum therapeutic for the treatment,of a ... is melioidosis which is the most common cause ...
... Office and Expanded Team Demonstrates USC,s Increased ... Positions USC to Strengthen and Leverage Robust ... ANGELES, Oct. 8 In a move that,demonstrates ... breakthrough research in the biosciences, the USC,Stevens Institute ...
... will market Salugen,s DNA-customized nutritional solutions ... ... Oct. 19 Salugen(R) ( http://www.salugen.com ),a leading personalized ... Southfield, Michigan to distribute Salugen,s,nutritional gene testing and DNA-customized ...
Cached Biology Technology:Implicit Awarded US $16.3 Million U.S. Government Contract to Develop Immunomodulatory Drug for Biodefense Threats 2The USC Stevens Institute for Innovation Opens Shop on USC Health Sciences Campus 2The USC Stevens Institute for Innovation Opens Shop on USC Health Sciences Campus 3The USC Stevens Institute for Innovation Opens Shop on USC Health Sciences Campus 4Salugen Expands U.S. Distribution and Announces a Partnership with DNA Dimensions to Bring DNA Customized Nutritional Solutions to Metro Detroit Area 2Salugen Expands U.S. Distribution and Announces a Partnership with DNA Dimensions to Bring DNA Customized Nutritional Solutions to Metro Detroit Area 3
... Product Goat polyclonal to Cholesterol ... Reactivity / Specificity Cross-reacts with ... Background Information Cholesterol oxidases exist ... oxidases and are implicated in bacterial pathogenesis. ...
Phospho-PERK (Thr980) Antibody...
Goat polyclonal to BACE1 ( Abpromise for all tested applications). entrezGeneID: 23621 SwissProtID: P56817...
Sheep polyclonal to Staphylococcus DNase ( Abpromise for all tested applications). Antigen: Full length native protein (purified)....
Biology Products: