Navigation Links
Need oxygen? Cells know how to spend and save

Researchers at Johns Hopkins have discovered how cells fine-tune their oxygen use to make do with whatever amount is available at the moment.

Too little oxygen threatens life by compromising mitochondria that power it, so when oxygen is scarce, cells appear to adjust by replacing one protein with an energy-efficient substitute that "is specialized to keep the motor running smoothly even as it begins to run out of gas," says Gregg Semenza, M.D., Ph.D., a professor of pediatrics and director of the vascular biology program in the Institute for Cell Engineering at Hopkins. "This is one way that cells maintain energy production under less than ideal conditions." A report on the work is in the April 6 issue of Cell.

"Cells require a constant supply of oxygen," Semenza says, "so it's vital for them to quickly react to slight changes in oxygen levels." The protein-swap is how they do it.

In the mitochondria, the tiny powerhouses found in every cell, energy is produced by passing electrons through a series of relay stations called cytochromes until they eventually join with oxygen to form water. This final step is directed by the protein cytochrome coxidase, or COX for short. If electrons react with oxygen before reaching COX, they generate "free radicals" that can damage or destroy cells. The mitochondria are designed to produce energy without excess free radical production at normal oxygen levels.

Semenza's team noticed that one particular component of the COX protein complex, COX4, comes in two different forms, COX4-1 and COX4-2. Under normal oxygen conditions, the cells' mitochondria contain mostly COX4-1. The researchers suspected that COX 4-2 might be the active protein under stressful, low-oxygen conditions, which the researchers refer to as hypoxia.

To test the idea, the team compared the growth of human cells in normal oxygen conditions (what's generally present in normal room air) compared to cells grown in hyp
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Jump-starting T Cells In Skin Cancer
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
4. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
5. Weill Cornell Research Reveals Secrets Of Trafficking Within Cells
6. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
7. Placenta Is A Rich Source Of Blood Stem Cells
8. UCSD Discovery Shows How Embryonic Stem Cells Perform Quality Control Inspections
9. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
10. Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis
11. Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Need oxygen Cells know how spend and save

(Date:1/22/2015)... Jan. 21, 2015  Analyst Report Issued by Small Cap IR. ... showed that planet-wide, transactions at merchants on the leading payment ... number of credit, debit, and prepaid cards reached 6.54 billion.  ... of fraudulent card usage in 2012, and credit and debit ...
(Date:1/22/2015)... NEW YORK , Jan. 22, 2015   EyeLock, Inc. ... announced it has appointed Steve Gerber to the ... Gerber will be responsible for leading development of mobile platforms ... 25 years of success and innovation in the semiconductor industry ...
(Date:12/22/2014)... Inc. (NASDAQ: NXTD and NXTDW) ("NXT-ID" or ... mobile commerce market, announces it has retained famous pickpocket, entertainer ... International CES debut of the Wocket™ biometric smart wallet.  ... NXT-ID booth January 6th and 7 th , 2015, demonstrating ...
Breaking Biology News(10 mins):$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4
... MD FASEB MARC (Maximizing Access to Research Careers) ... Society for the Study of Reproduction (SSR) Annual Meeting ... These awards are meant to promote the entry of ... of the basic science community and to encourage the ...
... systems work together to paralyze skeletal muscles during rapid eye ... 11 issue of The Journal of Neuroscience . The ... including narcolepsy, tooth grinding, and REM sleep behavior disorder. ... recalled dreams occur your eyes continue to move but ...
... has been awarded a grant expected to total more ... (NIH) National Institute of Allergy and Infectious Diseases (NIAID). ... vaccine against HIV and the disease it causes, AIDS. ... vaccine is urgently needed to slow and eventually eliminate ...
Cached Biology News:Study identifies how muscles are paralyzed during sleep 2Scripps Research Institute wins $77 million to develop AIDS vaccine center 2Scripps Research Institute wins $77 million to develop AIDS vaccine center 3
(Date:1/22/2015)... January 22, 2015 Diagenode, Inc., ... as the Bioruptor® and complete solutions for epigenetics ... chromatin immunoprecipitation, alleviating the need for manual processing. ... needed for ChIP of histones or transcription factors ...
(Date:1/22/2015)... Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... on advanced wound care, announces that AMNIOEXCEL® and ... been added to the Premier, Inc. Regenerative Skin ... for the AMNIOEXCEL® and AMNIOMATRIX® product lines, which ...
(Date:12/24/2014)... Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), today announced ... on May 4, 2015 (the "Annual Meeting"). Because ...
(Date:12/24/2014)... On Friday, December 19, 2014, President Obama ... Resolution Appropriations Act of 2015, which for the first ... through the Congressionally Directed Medical Research Programs (CDMRP) administered ... (HA), working in conjunction with its allies on Capitol ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... Inverness Medical,Innovations, Inc. (Amex: IMA ) ... dated January 31, 2008 and entitled "Inverness Medical,Innovations ... and Medical Device Conference on February 5, 2008." ... Company,s presentation. The,correct time of the presentation is ...
... Calif., Feb. 1 Edwards Lifesciences,Corporation (NYSE: ... technologies to,treat advanced cardiovascular disease, is scheduled to ... Medical Device,Conference at the Grand Hyatt Hotel in ... M. Abate, Edwards Lifesciences, corporate vice president, chief,financial ...
... Inc.,(Nasdaq: VRUS ) management will be presenting at ... February 11 - 13, 2008 at the,Waldorf-Astoria Hotel in ... provide an overview of the company on Monday,February 11, ... Salon. In,addition, Dr. Michelle Berrey, Pharmasset,s Chief Medical Officer, ...
Cached Biology Technology:Edwards Lifesciences to Present at the Merrill Lynch Global Pharmaceutical, Biotechnology & Medical Device Conference 2Pharmasset to Present at the BIO CEO & Investor Conference 2008 on Monday, February 11th 2
APG5 autophagy 5-like (S. cerevisiae)...
Human Jagged 2 Biotinylated Affinity Purified PAb...
Mouse/Rat WNK1 Affinity Purified Polyclonal Ab...
Griess Reagent component for determination of nitrite in aqueous solutions....
Biology Products: