Navigation Links
Navigating an integrated yeast network

Scientists have for the first time mapped multiple complex biological interactions in a yeast cell in a simple graphical form, enhancing our understanding of how the networks of interaction by which components of a cell influence one another. New research published in the Open Access journal Journal of Biology shows that such maps can also reveal cryptic interactions and enable accurate predictions about interactions that haven't been observed experimentally.

A living cell contains thousands of proteins, genes and macromolecules, enmeshed in complex webs of relationships involving direct or indirect contact. At the simplest level, some recurring patterns of interconnections occur more frequently than expected in randomized networks, and these are called 'network motifs'. Lan Zhang from Harvard Medical School, USA, and colleagues found that the concept of 'network themes' ?recurring complex patterns that encompass multiple occurrences of network motifs ?allows the building of 'thematic maps' of interactions between macromolecules that can be tied to biological phenomena and may help represent more fundamental network design principles than do simple motifs.

Zhang et al. integrated five different types of biological relationships found in the yeast Saccharomyces cerevisae: protein-protein interactions, genetic interactions, transcriptional regulation, sequence homology and expression correlation. The authors are the first to integrate so many types of data to search for network motifs. The authors conclude that most network motifs found in the integrated S. cerevisae network can be understood in terms of just a few network themes, associated with specific biological phenomena.

Their results also show that thematic maps can highlight previously unknown relationships between functional modules in a cell. In addition, they can be used to predict interactions that are hard to identify experimentally, or to predict the function of genes involved in s pecific themes.

According to Markus Herrgard and Bernhard Palsson of University of California, San Diego, the authors' approach can be readily extended to different types of cellular networks. "[T]he thousands of physical and functional interactions that exist within all cells can begin to be untangled to provide [the] basis for detailed network reconstruction and to elucidate fundamental organizational principles of biological networks."

This press release is based on the following article:

Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone and Frederick P Roth

Journal of Biology 2005, 4:6 (1 June 2005).

This article is available free of charge


'"/>

Source:BioMed Central


Related biology news :

1. Navigating the brain for sense of direction as paradigm for higher cognitive functions
2. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
3. After the yeast is gone bacteria continue to develop flavor of sparkling wine
4. GlycoFi announces the first production of antibodies with human glycosylation in yeast
5. From a lowly yeast, researchers divine a clue to human disease
6. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
7. Engineered yeast speeds ethanol production
8. Primitive yeast yields secrets of human cholesterol and drug metabolism
9. Hives ferment a yeasty brew, attract beetle pest
10. New NIAID grants strengthen national biodefense and emerging infectious diseases research network
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/4/2017)... LAS VEGAS , Jan. 4, 2017 /PRNewswire/ ... in performance biometric sensor technology, today announced the ... Benchmark™ sensor systems, the highly-accurate biometric sensor ... ® biometric technology, experience and expertise. The ... of Benchmark designed specifically for hearables, and Benchmark ...
(Date:12/22/2016)... , Dec. 20, 2016  As part of its ... the leading personal genetics company, recently released its latest children,s ... . The book focuses on the topics of inheritance and ... Science Standards (NGSS) taught in elementary school classrooms in the ... a series by illustrator Ariana Killoran , whose previous ...
(Date:12/20/2016)... 2016 The rising popularity of mobility ... is stoking significant interest in keyless access systems. ... low energy (BLE), biometrics and near-field communication (NFC) ... of wireless technologies in the automotive industry. This ... access systems opens the market to specialist companies ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... PUNE, India , Jan. 19, 2017  Market Research Future ... The Global Market for Liquid Biopsy is growing rapidly and expected ... period. Market Highlights ... The Global Liquid Biopsy Market has been assessed as ... high growth figures and boom in the coming future. There has ...
(Date:1/19/2017)... ... January 19, 2017 , ... ... pharmaceutical research and development (R&D), today announced the launch of Data ... interpretation for the rapidly evolving field of precision medicine. , Data ...
(Date:1/19/2017)... -- AquaBounty Technologies, Inc. (AIM: ABTU; NASDAQ: AQB), a ... a majority-owned subsidiary of Intrexon Corporation (NYSE: ... of its common shares on the NASDAQ Stock Market ... "AquaBounty,s listing on NASDAQ represents an important milestone for ... U.S. markets as we advance plans for commercial production ...
(Date:1/19/2017)... ... January 19, 2017 , ... DaVita Clinical ... spectrum of drug and device development, and Prism Clinical Research , a ... today announced Verified Clinical Trials (VCT) has been selected by both ...
Breaking Biology Technology: