Navigation Links
Navigating an integrated yeast network

Scientists have for the first time mapped multiple complex biological interactions in a yeast cell in a simple graphical form, enhancing our understanding of how the networks of interaction by which components of a cell influence one another. New research published in the Open Access journal Journal of Biology shows that such maps can also reveal cryptic interactions and enable accurate predictions about interactions that haven't been observed experimentally.

A living cell contains thousands of proteins, genes and macromolecules, enmeshed in complex webs of relationships involving direct or indirect contact. At the simplest level, some recurring patterns of interconnections occur more frequently than expected in randomized networks, and these are called 'network motifs'. Lan Zhang from Harvard Medical School, USA, and colleagues found that the concept of 'network themes' ?recurring complex patterns that encompass multiple occurrences of network motifs ?allows the building of 'thematic maps' of interactions between macromolecules that can be tied to biological phenomena and may help represent more fundamental network design principles than do simple motifs.

Zhang et al. integrated five different types of biological relationships found in the yeast Saccharomyces cerevisae: protein-protein interactions, genetic interactions, transcriptional regulation, sequence homology and expression correlation. The authors are the first to integrate so many types of data to search for network motifs. The authors conclude that most network motifs found in the integrated S. cerevisae network can be understood in terms of just a few network themes, associated with specific biological phenomena.

Their results also show that thematic maps can highlight previously unknown relationships between functional modules in a cell. In addition, they can be used to predict interactions that are hard to identify experimentally, or to predict the function of genes involved in s pecific themes.

According to Markus Herrgard and Bernhard Palsson of University of California, San Diego, the authors' approach can be readily extended to different types of cellular networks. "[T]he thousands of physical and functional interactions that exist within all cells can begin to be untangled to provide [the] basis for detailed network reconstruction and to elucidate fundamental organizational principles of biological networks."

This press release is based on the following article:

Motifs, themes and thematic maps of an integrated Saccharomyces cerevisiae interaction network Lan V Zhang, Oliver D King, Sharyl L Wong, Debra S Goldberg, Amy HY Tong, Guillaume Lesage, Brenda Andrews, Howard Bussey, Charles Boone and Frederick P Roth

Journal of Biology 2005, 4:6 (1 June 2005).

This article is available free of charge


'"/>

Source:BioMed Central


Related biology news :

1. Navigating the brain for sense of direction as paradigm for higher cognitive functions
2. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
3. After the yeast is gone bacteria continue to develop flavor of sparkling wine
4. GlycoFi announces the first production of antibodies with human glycosylation in yeast
5. From a lowly yeast, researchers divine a clue to human disease
6. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
7. Engineered yeast speeds ethanol production
8. Primitive yeast yields secrets of human cholesterol and drug metabolism
9. Hives ferment a yeasty brew, attract beetle pest
10. New NIAID grants strengthen national biodefense and emerging infectious diseases research network
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/28/2016)... Synaptics (NASDAQ: SYNA ), a leading developer of human interface ... 31, 2015. --> --> ... percent compared to the comparable quarter last year to $470.5 million. ... million, or $0.93 per diluted share. --> ... of fiscal 2016 grew 9 percent over the prior year period ...
(Date:1/22/2016)... 22, 2016 ... of the  "Global Behavioral Biometric Market ... --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced ... Biometric Market 2016-2020"  report to their ... Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ...
(Date:1/20/2016)... Jan. 20, 2016   MedNet Solutions , an ... spectrum of clinical research, is pleased to announce the ... achievements are the result of the company,s laser focus ... eClinical , it,s comprehensive, easy-to-use and highly affordable ... --> Key MedNet growth achievements in 2015 include: ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016  Sangamo BioSciences, Inc. (NASDAQ: ... today that Edward Lanphier , Sangamo,s president and ... progress of Sangamo,s ZFP Therapeutic ® development programs ... 2:40 pm ET on Thursday, February 11, 2016, at ... Conference. The conference is being held in ...
(Date:2/4/2016)... N.J. , Feb. 4, 2016  CytoSorbents ... immunotherapy leader commercializing its flagship CytoSorb® blood filter ... surgery patients around the world, announced that CEO ... present at the Source Capital Group,s 2016 Disruptive ... update on the company.  Conference ...
(Date:2/4/2016)...  Spherix Incorporated (Nasdaq: SPEX ) -- an intellectual property ... intellectual property, today provided an update on the Company,s ... of Texas and announcing that ... Partes Re-examination ("IPR") proceedings that VTech and Uniden ... initiated on only certain claims of two of the ...
(Date:2/4/2016)... ... ... Many of the engineers at FireflySci, Inc. have been manufacturing quartz and ... other cuvette manufacturers is their supercharged customer service and their extensive database of glass ... flow of inside information, they have recently revamped their manufacturing techniques to reduce lead ...
Breaking Biology Technology: