Navigation Links
Navigable nanotransport

To accurately transport pharmaceutical agents to their specific target organs or cell types, you need a good carrier: nanoscopic capsules with surface elements that can "recognize" the target in question could do the trick.

To date, all methods for the production of such tiny capsules require preorganized structures or "molds" to shape hollow spheres and most methods require a lengthy, tedious synthetic or purification procedure. Korean researchers led by Kimoon Kim have now developed a very simple novel approach for the direct production of polymeric nanocapsules. As described in the journal Angewandte Chemie, this method is generally applicable to any monomers as long as they have a flat core and multiple polymerizable groups at the periphery. Additionally, if building block are chosen that are able to bind specific (bio)molecules very tightly, the surface of the capsule can be easily decorated with species that are recognized by cells, showing the transporter the way to reach its goal, such as a tumor cell.

To demonstrate the power of their new concept, Kim and his team chose rigid, disk-shaped monomers equipped with a ring of special molecular "hooks" that can be activated by UV light. When a solution containing these disks is irradiated, the hooks grab on to each other, linking the disks into little, two-dimensional "patches" that in turn hook on to other patches. Once they reach a certain size, the patches bend around and close off to form hollow spheres, which can then be filled with guest molecules. The size of the spheres is very uniform and depends largely on the solvent in which the linking reaction takes place. The researchers used this method to produce capsules with diameters ranging from 50 to 600 nm.

The little disks used in this process deserve special consideration: Kim and his colleagues chose to use curcurbiturils. These disk-shaped molecules have a cavity at their center. As their shape resembles a hollowed-out pumpkin
'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2

Related biology news :

1. Major new UNC-based drinking water study suggests pregnancy fears may be overstated
2. Major breakthrough in the treatment of cancers and infectious diseases
3. Major advance made on DNA structure
4. Major WHO study concludes calcium supplements can reduce complications during pregnancy
5. Major obesity gene is lost in the shuffle
6. Major initiative proposed to address amphibian crisis
7. Major cancer study aims to identify protein markers for early-stage disease
8. Major link in brain-obesity puzzle found
9. Bioartificial kidney under study at MCG
10. W.M. Keck Foundation funds study of friendly microbes
11. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Navigable nanotransport

(Date:12/17/2014)... , Dec. 15, 2014 The Defense Logistics ... to detect and prevent counterfeit microcircuits from entering into ... performing an in-house microcircuit anti-counterfeit initiative dubbed DNA marking. ... while increasing their reliability throughout the supply chain. The ...
(Date:12/17/2014)... 2014 Valencell, a leader in performance biometric data ... industry leaders such as Intel, Jabra, Atlas, and Scosche ... products. These products will be showcased at CES 2015, ... . "Our partners choose PerformTek ...
(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally transforming the ... at international borders. Over the past decade, ePassports, biometric ... to self process through border control via eGates and ... of airports, seaports, and land borders across the globe. ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... 2010 - Novocure reported today that patients with advanced ... in survival time when tumor treating fields (TTF) therapy ... outcomes for patients receiving chemotherapy alone. Dr. Miklos Pless, ... center in Switzerland, presented the data at the European ...
... have reported direct evidence that taking up smoking results in ... results were reported at the 35th Congress of the European ... link between smoking and cancer has been established for decades, ... Institute of Cancer Studies, Birmingham, who presented the results. Smoking ...
... at Chicago College of Medicine have found how gene expression ... unusual types of breast tumors. Their findings may offer new ... 8 issue of the Journal of Biological Chemistry, ... Approximately 70 percent of breast cancers express the estrogen receptor. ...
Cached Biology News:Novocure reports data showing TTF therapy in combination with chemotherapy has the potential to increase overall survival for patients with advanced non-small cell lung cancer 2Study reveals cancer-linked epigenetic effects of smoking 2Clue to unusual drug-resistant breast cancers found 2
(Date:1/23/2015)... stimulate microbial activities in soil. These microorganisms generate plant ... in the soil or in the rhizosphere. The demand ... reducing environmental pollution and on reducing the usage of ... bio fertilizers market with analysis and forecasting of the ...
(Date:1/22/2015)... 2015  Transwestern | RBJ today announces the firm brokered a ... Shire a leading biopharmaceutical company, at Two Ledgemont Center in ... Robert Richards , president, and Brian Cohen , senior ... five-floor building at 95 Hayden Ave. Photo - ...
(Date:1/22/2015)... Johnston, RI (PRWEB) January 22, 2015 ... State , The growing team of brand-neutral, independent consultants, ... CIO Philip Rogers explained that over the years, his ... including , Moroso, Town of Plainfield, as well as ...
(Date:1/22/2015)... January 22, 2015 Controlled Substance Compliance ... which helps companies check the legal requirements around using ... to China. , As their international operations expand ... adopting software solutions built as a result of the ...
Breaking Biology Technology:Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 2Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 3Biofertilizers Market Expected to Reach $1,649.7 Million by 2019 - New Report By MarketsandMarkets 4Transwestern | RBJ Advises Shire in 202,000 SF Lease, Creating Boston's Largest Suburban Biotech Campus 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Global Compliance Service for Controlled Substances to Expand to China 2
... Siemens Medical Solutions, (http://www.usa.siemens.com/healthcareit ) continues ... clinical and financial workflows through,Soarian(R), its next-generation, ... Assembly and Annual Meeting of the,Radiological Society ... to 30 at,McCormick Place in Chicago (Booth ...
... Human Health Business, Creates a Global Leader in, Animal ... ... Projects, KENILWORTH, N.J., ... it has completed the,acquisition of Organon BioSciences N.V., creating a stronger ...
... /Xinhua-PRNewswire-FirstCall/ -- Pharmaxis,(ASX: PXS, Nasdaq: PXSL) today announced ... Plan which closed on 9 November 2007. Shareholders ... up to $5,000 worth of,shares each at the ... placement. A total of 2,496 shareholders participated ...
Cached Biology Technology:Siemens Customers Innovate Their Clinical and Financial Workflows with Help from Soarian 2Siemens Customers Innovate Their Clinical and Financial Workflows with Help from Soarian 3Schering-Plough Completes Acquisition of Organon BioSciences 2Schering-Plough Completes Acquisition of Organon BioSciences 3Schering-Plough Completes Acquisition of Organon BioSciences 4Schering-Plough Completes Acquisition of Organon BioSciences 5Pharmaxis Closes Share Purchase Plan 2
NF kappa B Related Sampler Kit 10g each...
Biotin anti-human CD164...
... Kits synthesize RNA probes with specific activities ... High specific activity, single-stranded RNA probes are ... hybridization, and blot hybridizations. MAXIscript Kits can ... modest amounts of unlabeled RNA (2-4 g/20ul ...
Mouse H60 Allophycocyanin MAb (Clone 205326) ENTREZ GeneID: 15101...
Biology Products: