Navigation Links
Natural protein stops deadly human brain cancer in mice

Scientists from Johns Hopkins and from the University of Milan have effectively proven that they can inhibit lethal human brain cancers in mice using a protein that selectively induces positive changes in the activity of cells that behave like cancer stem cells. The report is published this week in Nature.

The most common type of brain cancer-glioblastoma-is marked by the presence of these stem-cell-like brain cells, which, instead of triggering the replacement of damaged cells, form cancer tissue. Stem cells, unlike all other cells in the body, are capable of forming almost any kind of cell when the right "signals" trigger their development.

For their treatment experiment, the researchers relied on a class of proteins, bone morphogenic proteins, that cause neural stem-cell-like clusters to lose their stem cell properties, which in turn stops their ability to divide.

First they pretreated human glioblastoma cells with bone morphogenic protein 4 (BMP4), then injected these treated cells into mouse brains. In mice injected with cells that were not pretreated, large, invasive cancers grew. In the mice with BMP4-treated cells, no cancers grew at all. Three to four months after injection, all mice that got untreated cells died, and nearly all mice with BMP4-treated cells were alive.

Next, the scientists delivered slow-release BMP4-containing "beads" directly into mouse brains with implanted glioblastoma cells. Mice that got empty beads developed large malignant tumors and died. Mice with BMP4 beads survived much longer, and 80 percent survived four months after cancer cell implants.

"Our idea is to treat patients with BMP4 or something like it right after surgery to remove glioblastoma in hopes of preventing the regrowth of the cancer and improving survival time," says Alessandro Olivi, M.D., director of the Division of Neurosurgical Oncology at Hopkins and a contributor to the study.

Olivi says clinical studies usi ng BMP4 could begin within a year and, if successful, drug therapies could be available to the public within three to four years.

"This was proof of the idea that BMPs could stop glioblastoma by depleting the stem-cell-like population that feeds it," says Henry Brem, M.D., chairman of the Department of Neurosurgery at Hopkins and a collaborator in the study. "This opens exciting doors to future research into treatments and therapies for such a devastating disease."


'"/>

Source:Johns Hopkins Medical Institutions


Related biology news :

1. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
2. Natural Killers Could Lead to New Hepatitis Treatments
3. Natural tumor suppressor in body discovered by UCSD medical researchers
4. Naturally occurring asbestos linked to lung cancer
5. Natural compound from pond scum shows potential activity against Alzheimers
6. Natural selection at single gene demonstrated
7. Natural vitamin E tocotrienol reaches blood at protective levels
8. Natural pine bark extract relieves muscle cramp and pain in athletes and diabetics
9. Natural anti-viral enzyme helps keep cancer cells alive, researchers find
10. Natural polyester makes new sutures stronger, safer
11. Natural gut hormone offers hope for new obesity drug
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2018)... ... September 20, 2018 , ... Global ... in Berlin announce a collaboration to deliver the first integrated epitope determination and ... the HLA region. For the first time, fully characterized HLA sequences and their ...
(Date:9/12/2018)... PARK, Calif. (PRWEB) , ... September 10, 2018 ... ... that a paper detailing the performance of its new Multiplexed Ion Beam Imaging ... the September 6 issue. This study will also be shared during a webinar ...
(Date:9/7/2018)... ... 06, 2018 , ... Sensors Midwest (#SensorsMW18), the ... Sensors Expo & Conference , announces their partnership with Fraunhofer USA Center for ... Enabled Industrial IoT Certification Program. Taking place on October 17, 2018 at the ...
Breaking Biology News(10 mins):
(Date:9/15/2018)... ... 14, 2018 , ... Nationally recognized public accounting and consulting firm Cherry ... of the Firm’s Nashville practice, on her appointment to Launch Tennessee’s Board ... named Managing Partner of the Firm’s Nashville practice in December 2017 . In this ...
(Date:9/12/2018)... ... September 10, 2018 , ... Franz Inc. , ... technology, AllegroGraph , for Knowledge Graphs, and Semantic Web Company , developers ... today announced a partnership to develop the Noam Chomsky Knowledge Graph. This ...
(Date:9/12/2018)... ... September 11, 2018 , ... Sterlitech Corporation, ... Forward Osmosis (FO) membranes from Fluid Technology Solutions (FTS H2O) to their offering ... are constructed from cellulose triacetate (CTA) material. The highly hydrophilic nature of the ...
(Date:9/7/2018)... ... ... Now available on live stream, the NanoScientific Symposium on SPM at SUNY ... panel of industry leaders from Harvard, Cornell, RPI, IBM, SUNY and more to discuss ... the field. Register today to be a part of the nanometrology conference that ...
Breaking Biology Technology: