The second study involved 47 participants with diabetic microangiopathy (a disorder of the smallest veins commonly associated with diabetes), or intermittent claudication (a blood vessel disease that causes the legs to easily cramp).This study also used a two-week pre-trial observation period followed by a week of supplementing with Pycnogenol (200 mg per day for one week), followed by a week of observation without Pycnogenol supplementation.
Patients with diabetic microangiopathy had a 20.8 percent reduction in pain, while participants with claudication experienced a 21 percent decrease in the amount of pain experienced while supplementing with Pycnogenol. Results indicated participants who took placebo experienced no decrease in pain.
Cramps are a common problem for people of all ages, ranging to the extreme fit and healthy to people who suffer from health problems. Previously, magnesium was hailed as the natural approach for relieving muscle cramps, however studies continue to show magnesium to be inefficient for reducing muscle cramps.
"Pycnogenol improves the blood supply to muscle tissue creating a relief effect on muscle cramping and pain. Poor circulation in the muscle is known to cause cramps and Pycnogenol improved the cramping in patients due to a stimulation of blood flow to their muscle tissue. Nitric oxide (NO) a blood gas, is well known to enhance blood flow and Pycnogenol may be influencing the activity of NO," said Rohdewald. "The insufficient production of NO is the common denominator responsible for impaired blood flow in vascular disease."
Strenuous exercise is known to involve muscle damage which may be followed by symptoms of inflammation. In separate studies published this year and in 2004 and 2005, Pycnogenol demonstrated its anti-inflamma