Navigation Links
Natural compound from 'pond scum' shows potential activity against Alzheimer's

A compound isolated from a cyanobacterium, a type of blue-green algae known as Nostoc, shows promise of becoming a natural drug candidate for fighting Alzheimer's and other neurodegenerative diseases, according to an in vitro study by researchers in Switzerland. It is believed to be the first time that a potent agent against Alzheimer's has been isolated from cyanobacteria, commonly known as 'pond scum.' The study was published in the Dec. 26 issue of the Journal of Natural Products, a monthly peer-reviewed joint publication of the American Chemical Society and the American Society of Pharmacognosy.

Cyanobacteria and other marine natural products have been increasingly found to be a promising source of drug candidates for fighting a variety of human diseases, including cancer and bacterial infections, but their chemistry has been largely unexplored, experts say. Now, a common marine organism could lead to yet another potential health benefit, says study leader Karl Gademann, Ph.D., an organic chemist at the Swiss Federal Institute of Technology (ETH) in Zürich. Gademann's lab specializes in identifying, synthesizing and studying new bioactive compounds from natural sources.

There is no cure for Alzheimer's at present, although cholinesterase inhibitors have shown promise for delaying or preventing the symptoms of mild to moderate forms of the disease, experts say. The newly isolated compound, nostocarboline, was shown to be a potent inhibitor of cholinesterase -- a brain chemical thought to be important for memory and thinking -- whose breakdown has been associated with the disease's progression. The natural compound's potency is comparable to galanthamine, a cholinesterase inhibitor already approved for the treatment of Alzheimer's, the researchers say.

As with any promising structure, it could be many years before the new compound is tested as a drug candidate in humans, the scientists caution. In addition to Gademann, others invo lved in this study include Friedrich Jüttner and Paul Becher of the University of Zürich and Julien Beuchat, currently with the Université de Lausanne in Switzerland.


'"/>

Source:American Chemical Society


Related biology news :

1. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
2. Natural Killers Could Lead to New Hepatitis Treatments
3. Natural tumor suppressor in body discovered by UCSD medical researchers
4. Naturally occurring asbestos linked to lung cancer
5. Natural selection at single gene demonstrated
6. Natural vitamin E tocotrienol reaches blood at protective levels
7. Natural pine bark extract relieves muscle cramp and pain in athletes and diabetics
8. Natural protein stops deadly human brain cancer in mice
9. Natural anti-viral enzyme helps keep cancer cells alive, researchers find
10. Natural polyester makes new sutures stronger, safer
11. Natural gut hormone offers hope for new obesity drug
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/7/2018)... ... September 06, 2018 , ... CTL Medical ... purchase its commercial spine business, which includes its complete portfolio of spine-related patents ... that result from it. The deal will make CTL Medical the world’s exclusive ...
(Date:8/31/2018)... ... 30, 2018 , ... CallTower is pleased to announce Jason Ulm, ... telecommunications experience and over ten years in executive leadership. Prior to joining CallTower, Jason ... early 2018. , In this new role, Jason will manage CallTower’s ...
(Date:8/31/2018)... Calif. (PRWEB) , ... August 30, 2018 , ... ... firm for the life sciences and healthcare industries, has received the 2018 Services Partner ... The award was presented by Box SVP of Business Development and Platform Sales, Niall ...
Breaking Biology News(10 mins):
(Date:8/21/2018)... ... August 21, 2018 , ... The Connecticut Technology Council (CTC) and Marcum ... fastest growing technology companies in Connecticut. This year’s group of top-ranked companies will be ... at the Connecticut Convention Center in Hartford. A complete list of the Marcum Tech ...
(Date:8/17/2018)... (PRWEB) , ... August 16, 2018 , ... ... organization (CRO) is pleased to announce the expansion of their team. Dr. Dawn ... hired to launch an innovative large molecule LC-MS/MS group that will specialize in ...
(Date:8/17/2018)... ... August 17, 2018 , ... VANCOUVER, ... Environmental Repositories (ISBER) is pleased to announce the release of the Russian translation ... originally released in January 2018, is a practice-changing publication aimed at advancing the ...
(Date:8/14/2018)... ... August 14, 2018 , ... Buprenorphine (BUP) ... disorder. BUP is often prescribed as a sublingual co-formulation with the opioid antagonist ... webinar, participants will learn from a review of the pharmacokinetics of BUP, NBP, ...
Breaking Biology Technology: