Navigation Links
Nanotubes used for first time to send signals to nerve cells

Texas scientists have added one more trick to the amazing repertoire of carbon nanotubes -- the ability to carry electrical signals to nerve cells.

Nanotubes, tiny hollow carbon filaments about one ten-thousandth the diameter of a human hair, are already famed as one of the most versatile materials ever discovered. A hundred times as strong as steel and one-sixth as dense, able to conduct electricity better than copper or to substitute for silicon in semiconductor chips, carbon nanotubes have been proposed as the basis for everything from elevator cables that could lift payloads into Earth orbit to computers smaller than human cells.

Thin films of carbon nanotubes deposited on transparent plastic can also serve as a surface on which cells can grow. And as researchers at the University of Texas Medical Branch at Galveston (UTMB) and Rice University suggest in a paper published in the May issue of the Journal of Nanoscience and Nanotechnology, these nanotube films could potentially serve as an electrical interface between living tissue and prosthetic devices or biomedical instruments.

"As far as I know, we're the first group to show that you can have some kind of electrical communication between these two things, by stimulating cells through our transparent conductive layer," said Todd Pappas, director of sensory and molecular neuroengineering at UTMB's Center for Biomedical Engineering and one of the study's senior authors. Pappas and UTMB research associate Anton Liopo collaborated on the work with James Tour, director of the Carbon Nanotechnology Laboratory at Rice's Richard E. Smalley Institute for Nanoscale Science and Technology, Rice postdoctoral fellow Michael Stewart and Rice graduate student Jared Hudson.

The group employed two different types of cells in their experiments, neuroblastoma cells commonly used in test-tube experiments and neurons cultured from experimental rats. Both cell types were placed on ten-layer-thick "mat s" of single-walled carbon nanotubes (SWNTs) deposited on transparent plastic. This enabled the researchers to use a microscope to position a tiny electrode next to individual cells and record their responses to electrical pulses transmitted through the SWNTs.

In addition to their electrical stimulation experiments, the scientists also studied how different kinds of SWNTs affected the growth and development of neuroblastoma cells. They compared cells placed on mats made of "functionalized" SWNTs, carbon nanotubes with additional molecules attached to their surfaces that may be used to guide cell growth or customize nanotube electrical properties, to cells cultured on unmodified "native" carbon nanotubes and conventional tissue culture plastic.

"Native carbon nanotubes support neuron attachment and growth well -- as we expected, better than the two types of functionalized nanotubes we tested," Pappas said. "Next we want to find a way to functionalize the nanotubes to make neuron attachment and communication better and make these surfaces more biocompatible."

Another avenue Pappas wants to explore is finding out whether nanotubes are sensitive enough to record ongoing electrical activity in cells. "Where we want to get to is a device that can both sense and deliver stimuli to cells for things like prosthetic control," Pappas said. "I think it's definitely doable, and we're pursuing that with Jim Tour and his group. It's great to be able to work with a guy who's on the cutting edge of nanoelectronics technology -- he seems to develop something new every week, and it's really become a great interaction."


'"/>

Source:University of Texas Medical Branch at Galveston


Related biology news :

1. Nanotubes inspire new technique for healing broken bones
2. A genes first kiss sets off that affair known as puberty
3. Love at first smell
4. Worlds largest rainforest drying experiment completes first phase
5. PCRM develops worlds first cruelty-free insulin assay
6. Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses
7. World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics
8. DuPonts first biologically derived polymer receives global recognition
9. Anti cancer virotherapy well tolerated in first human administration, research finds
10. Unlike other mammals, newborn dolphins and orcas stay active 24/7 during first months of development
11. The first impact factor for PLoS Biology ?13.9
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... -- On Monday, the Department of Homeland Security (DHS) ... for the Biometric Exit Program. The Request for Information ... explains that CBP intends to add biometrics to confirm ... States , in order to deter visa overstays, ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/15/2016)... , June 15, 2016 ... market report titled "Gesture Recognition Market by Application Market - Global ... 2016 - 2024". According to the report, the  global ... billion in 2015 and is estimated to grow ... 48.56 billion by 2024.  Increasing application ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... June 27, 2016  Global demand for enzymes ... through 2020 to $7.2 billion.  This market includes ... cleaning products, biofuel production, animal feed, and other ... and biocatalysts). Food and beverages will remain the ... increasing consumption of products containing enzymes in developing ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading ... the Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio ... and clinical trial team. , Using the CONSULT module, patients and physicians can schedule ...
(Date:6/27/2016)...   Ginkgo Bioworks , a leading organism ... today awarded as one of the World Economic ... most innovative companies. Ginkgo Bioworks is engineering biology ... world in the nutrition, health and consumer goods ... customers including Fortune 500 companies to design microbes ...
(Date:6/24/2016)... ... ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical journal ... Their findings are the subject of a new article on the Surviving Mesothelioma website. ... the blood, lung fluid or tissue of mesothelioma patients that can help point doctors ...
Breaking Biology Technology: