Navigation Links
Nanotextured implant materials: blending in, not fighting back

Biomedical engineers are constantly coming up with ways to repair the human body, replacing defective and worn out parts with plastic, titanium, and ceramic substitutes ?but the body does not always accept such substitutes seamlessly. Engineers from Brown and Purdue universities have found that simply changing the surface texture of implants can dramatically change the way cells colonize a wide variety of materials.

Two recent experiments have focused on the materials used in stents ?those springy little cylinders that hold open once-clogged arteries ?and artificial blood vessels. Currently only about 30 percent of small diameter blood vessel grafts (less than 6 mm diameter) last more than five years, and up to 20 percent of stents need to be replaced because the artery walls thicken in and around them in a process known as restenosis. Drug-coated stents were introduced years ago as one way to combat this problem, but concerns have surfaced recently about increased clotting.

Instead of using chemistry to fight the body's response to such foreign materials, Thomas Webster, an associate professor of engineering, and Karen Haberstroh, an assistant professor of engineering, thought maybe they could use physical structure to allow the foreign materials to blend in better. "What we're trying to do is fundamentally different," says Webster. "We're trying to find materials that the body accepts, rather than develop drugs or develop materials that will kill a cell ?no matter if it kills a bad cell or a good cell. We're trying to find materials that accept good cells, as opposed to killing off bad cells."

Normal healthy blood vessels have a thin lining of specialized cells called the endothelium, surrounded by a thicker layer of smooth muscle cells that make up the arterial wall. The proteins collagen and elastin make up much of this lining and create a texture of fine nanoscale bumps on the inside of the blood vessel. This contrasts strongly with
'"/>

Source:Brown University


Page: 1 2 3

Related biology news :

1. Ophthalmologists implant five patients with artificial silicon retina microchip
2. Polymers with copper show promise for implanted sensors
3. Engineers improve plastics potential for use in implants by linking it to biological material
4. Innovative coating could give medical implants a longer life
5. Magnetic probe successfully tracks implanted cells in cancer patients
6. Sooner is better with cochlear implants, Stanford scientist shows
7. Breast implants not associated with cancer risk, study reports
8. New implanted contacts designed to fix nearsightedness
9. With cochlear implants, earlier use leads to better speech
10. Protein-coated dental implants could improve bone regeneration
11. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nanotextured implant materials blending not fighting back

(Date:7/29/2014)... new study from UC San Francisco is the first ... accumulate overtime and accelerate cellular aging, these negative effects ... and sleeping well. , "The study participants who ... shortening than the ones who didn,t maintain healthy lifestyles, ... lead author Eli Puterman, PhD, assistant professor in the ...
(Date:7/28/2014)... the United States have a circulatory problem of the ... and may even require surgery in serious cases. This ... in turn, limb amputation. , At The University of ... scientists tested a non-surgical preventative treatment in a mouse ... increased blood circulation. Their proof-of-concept study appears in ...
(Date:7/28/2014)... a wild relative of the domestic tomato, has been ... labs headed by Professors Neelima Sinha and Julin Maloof ... new genome information may help breeders produce tastier, more ... the journal Nature Genetics , was lead by ... The UC Davis labs carried out work on the ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Scientists discover genetic switch that can prevent peripheral vascular disease in mice 2
... Naturforschung will collaborate on the publication of two ... Palaeobiodiversity and Palaeoenvironments and Marine Biodiversity ... through Springer,s abstracting and indexing services and innovative ... both electronic and print versions. Palaeobiodiversity ...
... Current research suggests that a new technique to ... tissue samples. The related report by Balic et ... tissues from colorectal cancer patients using quantitative high-resolution melting ... Journal of Molecular Diagnostics . DNA in ...
... genome eight years ago, enormous progress has been made ... most human genes is still barely understood. An important ... or protein is to compare its sequence with the ... easier to investigate. From the functions of related genes ...
Cached Biology News:Springer and Senckenberg society to collaborate on life sciences and geosciences journals 2New technique for cancer screening 2Relationships in rank and file 2Relationships in rank and file 3Relationships in rank and file 4
(Date:7/29/2014)... 2014 Human Longevity, Inc. (HLI), a genomics ... extending the healthy, high performance human life span, today ... an expert in machine learning and machine translation as ... from Google where he was Distinguished Research Scientist and ... to HLI Co-Founder and CEO, J. Craig Venter ...
(Date:7/29/2014)... ELLICOTT CITY, Md. , July 29, 2014 ... has announced a new and updated program for ... October 10 – 12, 2014 in Amelia ... sponsors, CROs, sites and investigators remains unchanged, however, ... more purposeful exchange and networking opportunity among all ...
(Date:7/29/2014)...  Discovery Laboratories, Inc. (Nasdaq: DSCO),  a specialty ... of respiratory critical care, will report its second quarter ... the open of the U.S. financial markets.  ... teleconference and webcast at 9:00 a.m. Eastern Time that ... management will discuss the 2014 second quarter financial ...
(Date:7/29/2014)... July 29, 2014  ImmunoClin Corporation (IMCL) is ... treatment of infectious diseases as well as nutraceuticals. ... prevention of pathologies like cardiovascular disease, Alzheimer,s disease ... ImmunoClin Corporation will complete the strategic relocation of ... , a key center of North American ...
Breaking Biology Technology:Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 2Franz Och, Ph.D., Expert in Machine Learning and Machine Translation, Joins Human Longevity, Inc. as Chief Data Scientist 3TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 2TransCelerate, Lilly, Pfizer, and FDA Highlight Collaborative Program at the Site Solutions Summit 3Discovery Labs to Report 2014 Second Quarter Financial Results and Hold Conference Call on Tuesday, August 5, 2014 at 9:00 a.m. Eastern Time 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3
... , MONTREAL, Dec. 7 /PRNewswire/ - Enerkem Inc. ... been selected by the U.S. Department of Energy (DOE) to ... of its waste-to-biofuels facility to be located in Pontotoc, Mississippi. ... been selected in the larger demonstration scale project category of ...
... 7 ATS Medical, Inc. (Nasdaq: ATSI ), ... services today announced it has received CE Mark approval ... the European Union, indicating it is compliant with relevant ... The Enable valve is the first surgical aortic valve ...
... ... develop systems biology-driven therapeutics to include small molecules, chemotherapy and RNAi candidates and ... ... announced today that it has acquired Hermes Biosciences, Inc. a private biotechnology company ...
Cached Biology Technology:Enerkem Awarded $50 Million Funding by U.S. Department of Energy for its Mississippi Biorefinery Project 2Enerkem Awarded $50 Million Funding by U.S. Department of Energy for its Mississippi Biorefinery Project 3ATS Medical Announces CE Mark Approval for the ATS 3f Enable Bioprosthesis 2ATS Medical Announces CE Mark Approval for the ATS 3f Enable Bioprosthesis 3ATS Medical Announces CE Mark Approval for the ATS 3f Enable Bioprosthesis 4Merrimack Pharmaceuticals Acquires Hermes Biosciences, Inc. 2Merrimack Pharmaceuticals Acquires Hermes Biosciences, Inc. 3
... the standard for sample concentration and drying. ... uses a combination of centrifugal force, heat and ... run. , SC210A comes equipped with:, ... chemical compatibility ...
... RC Maxi MB (for aqueous, other low ... evaporator systems respond to specific applications of ... safe concentration of heat-labile samples. The RC ... of cold traps and a wide selection ...
... The Jouan RC Standard Bio for ... applications of molecular biology and biochemistry for ... The RC systems can be expanded with ... wide selection of rotors (eliminating sample loss ...
... The Jouan RC10 series of vacuum concentrators/centrifugal ... protection features allied to rapid and safe ... can be combined with oil-free or high ... and a wide selection of rotors (eliminating ...
Biology Products: