Navigation Links
Nanotechnology to provide portable genetic risk detection

Currently being developed by the IST project OPTONANOGEN, a prototype of the system will initially be used to detect mutations of the BRCA1 gene that are responsible for between 2.5 and 5 per cent of the incidence of breast cancer in women. The final system, however, could be used to detect virtually any genetic anomaly as well as proteins linked to viruses, chemical contamination in food or water pollution.

"There are a broad variety of applications for this system, although the main market is in biomedicine," explains OPTONANOGEN coordinator Laura Lechuga at the National Microelectronics Centre (CNM) in Spain. "Though commercial biosensing systems exist they are larger and designed to be used in laboratories. We are the first to develop a fully integrated system on a small scale in this field."

The final device will be roughly the size of a human hand, allowing it to be used in doctors' surgeries to determine the genetic predisposition of a patient to certain diseases in a matter of minutes. That compares to the hours or even days it can take to carry out the same analysis in a laboratory, which is generally only used to test high risk groups such as women with a family history of breast cancer.

To detect genetic mutations the OPTONANOGEN system uses an array of 20 microcantilevers coated in nucleic acid that react when they come into contact with a DNA sample displaying the genetic anomaly. The sample is injected into the device via a microfluidic header and the deflection of the cantilevers ?by as little as 0.1 to 0.5 nanometres ?is picked up by a photodetector array based on the reflection of light off the cantilevers from Vertical Cavity Surface Emission Lasers (VCSELs).

"We've patented both the microcantilever set up and the optical detection system and we are due to take out a third patent on the microfluidic header, which is unique in that it uses individual inlet and outlet paths for each cantilever rather than one for the wh ole array, something that has never been achieved before," Lechuga says.

The cantilever array and microfluidic header are due to be low-cost components that would be disposable if used for medical analysis but which could be cleansed and reused for other applications.

After evaluation trials later this year, a commercial variant of the system is likely to be produced within one or two years by Sensia, a 15-month-old spin-off company from the CNM.


'"/>

Source:IST Results


Related biology news :

1. Nanotechnology may find disease before it starts
2. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
3. Nanotechnology propels advances in regenerative medicine research
4. Nanotechnology shows promise as next wrinkle fighter
5. Nanotechnology meets biology and DNA finds its groove
6. Experiments provide proof of how traveling in groups protects insects
7. Experiments provide proof of how traveling in groups protects insects
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. MetaChip provides quick, efficient toxicity screening of potential drugs
10. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
11. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/18/2016)... Calif. , Jan. 18, 2016  Extenua ... software that simplifies the use and access of ... and go-to-market partnership with American Cyber.  ... brings extensive experience leading transformational C4ISR and Cyber ... and integrating the latest proven technology solutions," said ...
(Date:1/11/2016)... 11, 2016 Synaptics Incorporated (NASDAQ: SYNA ... announced that its ClearPad ® TouchView ™ ... two separate categories in the 8 th Annual ... Technology Breakthrough. The Synaptics ® TDDI solution enables ... chain, thinner devices, brighter displays and borderless designs. ...
(Date:1/7/2016)... This BCC Research report studies the global ... devices, identifying newer markets and exploring the expansion of ... devices. Includes forecast from 2015 to 2020. ... explore the expansion of the present application market for ... biometric technology, determine its current market size, and estimate ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... 4, 2016  CytoSorbents Corporation (NASDAQ: CTSO ... flagship CytoSorb® blood filter to treat deadly inflammation ... world, announced that CEO Dr. Phillip Chan ... Capital Group,s 2016 Disruptive Growth & Healthcare Conference, ... Conference Presentation Details: Where: Convene ...
(Date:2/4/2016)... -- --> --> Q ... to provide the following update on recent corporate developments. ... 3 months we have significantly increased our cash position through ... a result, we have positioned ourselves to execute on the ... expect that development to continue on schedule. ...
(Date:2/4/2016)... Feb. 4, 2016  Spherix Incorporated (Nasdaq: SPEX ... and monetization of intellectual property, today provided an update ... the Northern District of Texas ... Inter Partes Re-examination ("IPR") proceedings that ... The IPR was initiated on only certain claims of ...
(Date:2/4/2016)... ... 2016 , ... Franz Inc. , an early innovator ... been recognized As “ Best in Semantic Web Technology - USA & Leader ... it’s our priority to showcase prominent professionals who are excelling in their industry ...
Breaking Biology Technology: