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Nanotechnology meets biology and DNA finds its groove

of "positioning the DNA molecule right where we want it to be. It is important that we can manipulate it with such fidelity."

The system, says Schwartz, promises bench scientists a convenient and easy way to make large numbers of individual DNA molecules accessible for study. The ability to quickly get lots of molecules lined up for sequencing and analysis, says Schwartz, means entire genomes - for species or individuals - could soon become more accessible to science.

Scientists, Schwartz explains, already know how to take DNA and stiffen it by removing salts from its chemical makeup. But confining the molecule and presenting it for analysis is laborious, engaging armies of lab techs worldwide to prepare DNA samples for their moment in the lab.

"To get DNA molecules to do this on surfaces is really hard," says Schwartz. The system developed by Schwartz, de Pablo and their colleagues could change all of that. By figuring out a way to take individual DNA molecules and present them in a confined, linear fashion, the genetic information encoded in the arrangement of the base pairs that make up the molecule can be scanned and read like a bar code.

The key to the new technology, argues Schwartz, is that the system is comprehensive, inexpensive and simple enough to lend itself to large-scale efforts to analyze DNA.

"It's a simple technology that works, and that's demonstrated to work for genome analysis," says de Pablo. "It's a very robust method that can be used in a variety of settings."

In addition to Schwartz and de Pablo, authors of the PNAS study include Kyubong Jo, Dalia M. Dhingra, Michael D. Grahm, Rod Runnheim and Dan Forrest, all of UW-Madison, and Theo Odijk of the Delft University of Technology.

The work underpinning the new DNA sampling method was supported by grants from the National Science Foundation and the National Institutes of Health.


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Source:University of Wisconsin-Madison


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