Navigation Links
Nanotech tools yield DNA transcription breakthrough

f transcription, the novel methods and findings of this work will aid future studies of other molecular machines involved in cell replication, transcription and protein synthesis."

The other study reported in Science was conducted by Ebright's laboratory in collaboration with Terence Strick's laboratory at the Institut Jacques Monod in Paris. The study by the Rutgers/Paris team used single-molecule nanomanipulation. The researchers used an instrument referred to as "magnetic tweezers" to hold, stretch and twist a single molecule of DNA having a single start site for transcription. They then read out changes in the conformation of the DNA molecule in real time as transcription occurred. The researchers showed that the molecular machine responsible for transcription unwinds adjacent DNA segments and pulls unwound DNA into itself during initial transcription ("scrunching").

In addition, the researchers showed that machine rewinds this unwound DNA when the machine leaves the start site and begins to move down the gene ("unscrunching"). Finally, the researchers showed that this process of scrunching and unscrunching occurs every time that transcription initiation occurs, indicating that the process is an obligatory part of transcription initiation.

Taken together, the two studies answer the longstanding question of how the machine acquires the energy required to break its interactions with, and leave, the start site. The machine acquires this energy by unwinding DNA and pulling unwound DNA during initial transcription. As DNA is unwound, energy is stored in the system, in the same manner, Ebright notes, as winding the rubber band of a rubber-band-powered airplane stores energy. Eventually, there is sufficient energy stored in the system that the machine is able to break its interactions with the start site, to shoot forward and, at the same instant, to rewind the unwound DNA.

Ebright stated that the publication of these findings
'"/>

Source:Rutgers, the State University of New Jersey


Page: 1 2 3 4

Related biology news :

1. Nanotechnology to provide portable genetic risk detection
2. Nanotechnology may find disease before it starts
3. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
4. Nanotechnology propels advances in regenerative medicine research
5. Nanotechnology shows promise as next wrinkle fighter
6. Nanotechnology meets biology and DNA finds its groove
7. Improved statistical tools reveal many linked loci
8. Virginia Tech group adds tools to DNA-targeted anti-cancer drugs
9. New tools used to control foodborne hepatitis A outbreaks related to green onions
10. MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools
11. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nanotech tools yield DNA transcription breakthrough

(Date:6/18/2013)... 2013  Paris Air Show – Marvin ... , a leading provider of innovative test solutions ... its solutions this week at the Paris ... challenges including increasingly complex armament systems with longer ... aerospace test solutions that address legacy system obsolescence. ...
(Date:6/18/2013)... expecting a very large "dead zone" in the Gulf ... in the Chesapeake Bay this year, based on several ... of Michigan, Louisiana State University, and the Louisiana ... of Mexico hypoxic "dead" zone will be between 7,286 ... the ten largest recorded. That would range from an ...
(Date:6/18/2013)... The herbal extract of a yellow-flowered mountain plant long ... lifespan of fruit fly populations by an average of ... it,s how Rhodiola rosea , also ... attention of study leaders Mahtab Jafari and Sam Schriner. ... manner completely unrelated to dietary restriction and affects different ...
Breaking Biology News(10 mins):Marvin Test Solutions Demonstrates Next-Generation Armament Test Solutions at Paris Air Show 2Marvin Test Solutions Demonstrates Next-Generation Armament Test Solutions at Paris Air Show 3NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 2NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 3NOAA, partners predict possible record-setting deadzone for Gulf of Mexico 4Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds 2
... MIT scientists have found a new way that DNA can ... discovering that a mold used to cast a metal tool ... shapes each showing distinct functional roles. Professor Manolis Kellis ... 1 issue of the journal Genes & Development that in ...
... Advanced Public Safety Minimizes ... Cost and Increases Accuracy -, WALL, N.J., ... International, Inc. (OTC Bulletin Board: BKYI), a leader ... Advanced Public Safety (APS), a leading provider of ...
... Cold Spring Harbor Laboratorys (CSHL) researcher Raffaella Sordella, Ph.D. ... Foundation to Conquer Lung Cancer. The two-year grant will ... class of genetic mutations that appear to be a ... of cancer deaths in the United States. The ...
Cached Biology News:MIT reports new twist in microRNA biology 2Missouri Police Department Introduces Electronic Traffic Citations 2Missouri Police Department Introduces Electronic Traffic Citations 3Missouri Police Department Introduces Electronic Traffic Citations 4Cold Spring Harbor Laboratory's lung cancer research program awarded $100,000 grant 2
(Date:6/19/2013)... Clinverse, Inc. , a ... trials, today announced it will be exhibiting and ... in Boston, June 24-26, 2013. Clinverse’s eClinical ... fully configurable, cloud-based clinical financial lifecycle system. , ... Clinverse’s eClinical Commerce Network, automates site contract set-up ...
(Date:6/19/2013)... 19, 2013  Continuing its long history of proven ... Beckman Coulter , Inc. announces the U.S. Food and ... AccuTnI+3 troponin I assay for use on its Access ... on Beckman Coulter,s troponin I test for ... the proven performance to continue providing dependability to laboratories ...
(Date:6/19/2013)... 2013 Today DuPont Executive Vice President ... become leaders in the greatest challenge facing our time ... 2050. Borel spoke at the International Food ... about urgent need for students to contribute their time ... sustainable and reached in collaboration with others. , “Food ...
(Date:6/19/2013)... BioConvergence team members Curtis Strother and ... BioLogistics Summit in San Francisco earlier this month. ... IQ and IQPC, addressed the increasingly complex logistical ... attributed to current trends of globalization, outsourcing, and ... is an increase in movement, which is often ...
Breaking Biology Technology:Clinverse, Inc. Exhibiting and Showcasing Its Technology at DIA 2013 2Beckman Coulter Announces FDA Clearance of New Access AccuTnI+3 Troponin I Assay for the Access 2 Immunoassay System 2Beckman Coulter Announces FDA Clearance of New Access AccuTnI+3 Troponin I Assay for the Access 2 Immunoassay System 3DuPont Leader Calls for New Generation of Food Visionaries to Fight Hunger 2BioConvergence® Presents at BioLogistics Summit on Risk Matrix for Biosamples during Shipment 2
... 16 - Over the past two decades,stem cell ... one that is a viable option for patients ... Researchers and,clinicians at the Adult Blood and Marrow ... Hackensack University Medical Center are,responsible for many of ...
... July 23 /PRNewswire-FirstCall/ - Roche,(SWX: ROG) and ARIUS ... have signed a definitive agreement for Roche to ... of approximately C$191 million. ARIUS is,the developer of ... and selects antibodies based on their functional,ability to ...
... CV Therapeutics,Inc. (Nasdaq: CVTX ) today announced ... after the market closes on Thursday, July 31,2008. Company ... EDT,2:00 p.m. PDT, on the company,s website., To ... Company,s website at, http://www.cvt.com and go to the ...
Cached Biology Technology:Stem Cell Transplantation Research at The Cancer Center at Hackensack University Medical Center Aims to Develop 'Designer' Transplants 2Stem Cell Transplantation Research at The Cancer Center at Hackensack University Medical Center Aims to Develop 'Designer' Transplants 3Stem Cell Transplantation Research at The Cancer Center at Hackensack University Medical Center Aims to Develop 'Designer' Transplants 4Roche starts acquisition process of ARIUS to gain access to new screening platform for antibody therapeutics 2Roche starts acquisition process of ARIUS to gain access to new screening platform for antibody therapeutics 3Roche starts acquisition process of ARIUS to gain access to new screening platform for antibody therapeutics 4CV Therapeutics to Announce 2008 Second Quarter Financial Results on Thursday, July 31, 2008 2