Navigation Links
Nanotech tools yield DNA transcription breakthrough

Rutgers researcher Richard H. Ebright and his collaborators have resolved key questions regarding transcription, the fundamental life process that was the subject of the 2006 Nobel Prize in Chemistry.

Transcription is the first step in the process cells employ to read and carry out the out instructions contained in genes. Transcription is carried out by a molecular machine known as RNA polymerase, which synthesizes an RNA copy of the information in DNA.

Two papers by Ebright and collaborators in the Nov. 17 issue of the journal Science define for the first time the mechanisms by which the machine begins synthesis of RNA and then breaks free from its initial binding site to move along DNA to continue synthesizing RNA.

The results establish that during transcription initiation the machine remains stationary at its initial binding site and "reels in" adjacent DNA segments, unwinding these segments and pulling the unwound DNA strands into itself. This remarkable mechanism, termed "DNA scrunching," enables the machine to acquire and accumulate the energy it needs to break its binding interactions with the initial binding site, and to begin to move down the gene.

"Our findings were made possible by newly developed, single-molecule methods," said Ebright, a Howard Hughes Medical Institute investigator and professor of chemistry and chemical biology at Rutgers, The State University of New Jersey. "These methods enabled us to analyze and manipulate individual molecules of the machine, one-by-one, as they carried out reactions."

The discoveries significantly advance our understanding of the structure and function of the molecular machine that carries out transcription, setting the stage for new opportunities in combating the bacterial diseases that kill 13 million persons each year worldwide.

"For six decades, antibiotics have been our bulwark against bacterial infectious diseases, but this bulwark now is collapsin
'"/>

Source:Rutgers, the State University of New Jersey


Page: 1 2 3 4

Related biology news :

1. Nanotechnology to provide portable genetic risk detection
2. Nanotechnology may find disease before it starts
3. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
4. Nanotechnology propels advances in regenerative medicine research
5. Nanotechnology shows promise as next wrinkle fighter
6. Nanotechnology meets biology and DNA finds its groove
7. Improved statistical tools reveal many linked loci
8. Virginia Tech group adds tools to DNA-targeted anti-cancer drugs
9. New tools used to control foodborne hepatitis A outbreaks related to green onions
10. MWG Biotech expands siMAX?siRNA portfolio with new scales, lengths and design tools
11. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nanotech tools yield DNA transcription breakthrough

(Date:8/19/2014)... An engineer at the University of Liverpool has found ... to communicate with the body. , Dr Paolo Paoletti, ... developed a mathematical model for earthworms and insect larvae ... bodied animals get around. , The most widely accepted ... which states that the central brain of these creatures ...
(Date:8/19/2014)... Electroacupuncture has traditionally been used to treat pain, ... injury is still unknown. In a recent study ... (Vol. 9, No. 14, 2014), rat models of ... root (associated with upper-limb chronic neuropathic pain) were ... (LI04), Zusanli (ST36) and Yanglingquan (GB34). After electroacupuncture ...
(Date:8/19/2014)... sensors already exist in different forms, they have not ... of production. Now researchers from the University of Surrey ... treated common elastic bands with graphene, to create a ... and can be made cheaply. , Once treated, ... material with graphene - which imparts an electromechanical response ...
Breaking Biology News(10 mins):Secrets of how worms wriggle uncovered 2
... and parasitoids, has been going on for more than 34 ... protected area of approximately 1200 km2 in northwestern Costa Rica. ... butterflies are estimated to live in ACG. Their caterpillars are ... of species. However, most of those wasps have never been ...
... Engineering (NCE) at New Jersey Institute of Technology (NJIT) will host ... in the Campus Center Atrium. Proceeds from the event will ... NCE Dean,s Fund. "NCE has a long tradition ... them hands-on experiences along the way," said Interim Dean Basil C. ...
... from Uppsala University shows that saturated fat builds more fat ... study on humans to show that the fat composition of ... the risk of cardiovascular disease but also determines where the ... recently been published in the American journal Diabetes . ...
Cached Biology News:Almost 200 new species of parasitoid wasps named after local parataxonomists in Costa Rica 2NJIT's Newark College of Engineering announces honorees for annual Salute to Excellence 2NJIT's Newark College of Engineering announces honorees for annual Salute to Excellence 3Abdominal fat accumulation prevented by unsaturated fat 2Abdominal fat accumulation prevented by unsaturated fat 3
(Date:8/18/2014)... NYElectronic devices with unprecedented efficiency and data ... that use built-in electric polarizations to read ... inside most popular data-driven technology. But ferroelectrics ... blocks, including a curious habit of "forgetting" ... the U.S. Department of Energy,s Brookhaven National ...
(Date:8/18/2014)... , Aug. 18, 2014 TNI BioTech, Inc. ... pioneering the manufacturing and marketing of innovative therapies for ... Company is providing a second notice of TNI BioTech,s ... making the announcement, Noreen Griffin , founder and ... advance for your participation in the Annual Meeting. On ...
(Date:8/16/2014)... 2014 Firms in the ... and advisory services to businesses, government bodies and ... services are highly diverse as operators assist a ... from geological and geophysical consulting services to risk ... past five years, the recovery of the Canadian ...
(Date:8/15/2014)... Aug. 15, 2014   Hospira, Inc. (NYSE: ... injectable drugs and infusion technologies, today announced that the ... Conference on Tuesday, Sept. 9, 2014, in ... scheduled to begin at 11:45 a.m. Eastern time on ... all interested parties through a live audiocast accessible via ...
Breaking Biology Technology:Promising ferroelectric materials suffer from unexpected electric polarizations 2Promising ferroelectric materials suffer from unexpected electric polarizations 3Promising ferroelectric materials suffer from unexpected electric polarizations 4TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 2TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 3TNI BioTech Inc., provides 2nd Notice of Annual Meeting September 4, 2014 4Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 2Scientific and Economic Consulting in Canada Industry Market Research Report Now Available from IBISWorld 3
... Mich., Nov. 10 MichBio, the association for,Michigan,s biosciences ... aimed at manufacturers who are looking to diversify into,the ... annual gathering,of biosciences professionals in the state and will ... Novi, MI., Both manufacturing sessions are scheduled for ...
... the Term of the ... ... Processing Ltd.) ( http://www.bsp.co.il/ ), an Israeli company that,develops and markets ... announced that it has signed an,exclusive distribution agreement with CMP Trading ...
... LAS VEGAS, NV, Nov. 10 /PRNewswire-FirstCall/ - Diagnostic ... Company has,entered a purchase agreement to acquire Canadian ... remote readings of MRI,s, CT,PET, CAT and X-rays. ... radiology services to its indigenous community 24hrs per ...
Cached Biology Technology:MichBio Expo Will Feature Sessions for Michigan Manufacturers Interested in Entering Medical Device Market 2BSP Signs Agreement With CMP Trading for Distribution of HyperQ(TM) Stress System, for Early Detection of Ischemic Heart Disease, in South Korea 2Diagnostic Imaging - Enters Purchase Agreement to Acquire Teleradiology Company 2
... tissue panels are designed for studying ... or proteins of interest in different ... positively charged glass slides. Total RNA ... identical format, and cDNA from those ...
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
... The T2-02 diaphragm pump features T ... and achieves remarkable performance and efficiency. With ... performance range, T2-02 is ideal for use ... Offers ultra-compact size, long life, and high ...
Biology Products: