Navigation Links
'Nanospheres' that block pain of sensitive teeth

Nanospheres could help dentists fill the tiny holes in our teeth that make them incredibly sensitive, and that cause severe pain for millions of adults and children worldwide.

Preliminary research presented today at the Institute of Physics conference EMAG-NANO 2005 shows that creating tiny spheres of a ceramic material called hydroxyapatite could be a long term solution or cure for sensitive teeth.

Sensitive teeth or 'dental hypersensitivity' is a condition that arises when the dentine of the tooth is exposed. The dentine is made up of thousands of tiny fluid-filled channels which radiate outwards from the nerve endings at the centre of the tooth. Heat, some chemicals, and physical contact can cause the fluid in these channels to move ?in or out ?triggering the nerve endings and causing sharp pain.

If these channels (or 'tubules') are fully or partially blocked, the flow can be reduced and the pain stopped or significantly reduced. Currently, the only way to treat this condition is through good dental hygiene - using special toothpastes and fluorine mouthwashes which encourage re-mineralization of the dentine coating.

Jonathan Earl, David Wood and Steve Milne from the Institute of Materials Research at the University of Leeds have found that the most successful particle shape for filling these channels is a 'nanosphere' and are now trying to synthesize nanospheres of hydroxyapatite. Hydroxyapatite is a ceramic material which is highly compatible with teeth and bone and so is widely used by medics for bone grafts or dental coatings (because it binds strongly with the bone material).

Earl and his colleagues grew hydroxyapatite at various pH levels to vary the size of the particles it is made up of. At normal pH, it is composed of long rod-like structures but at high pH levels the particles of hydroxyapatite become smaller and more rounded, better for fitting inside the tiny channels in teeth.

To see whether nanospher es would be successful at filling the channels they used commercially available silica nanospheres of around 40nm in diameter.

Earl said: "We found these tiny spheres are really good at filling the channels in teeth, packing inside them quite evenly and going down the holes to a good depth. They'd be the perfect shape of particle for filling these channels and reducing or preventing the pain caused by sensitive teeth".

The next stage of their research will be to work out how to synthesize nanospheres of hydroyapatite or a combination of hydroxyapatite and fluorine which would fill the holes and encourage re-mineralization at the same time and so be an incredibly powerful repair tool for dentists.


'"/>

Source:Institute of Physics


Related biology news :

1. Tamoxifen-like drug suggests new ways to selectively block estrogen
2. New type of rejection blocker protects kidneys after transplant
3. Frog peptides block HIV in lab study
4. Survival of heart patients on beta-blockers varies greatly with genetic variation
5. Newfound roadblock to interferon effectiveness against malignant melanoma
6. UCSD study clarifies insulins role in blocking release of energy in patients with type II diabetes
7. Scientists use gene transfer technology and common virus to block neuropathic pain in animals
8. Scientists use gene transfer technology and common virus to block neuropathic pain
9. Polymer gel can block toxic leakage problem in gene therapy
10. Brainstem blocks pain to protect key behaviors
11. Scientist uses form to explain function of key building blocks of life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... 2016 On Monday, the Department of Homeland ... share solutions for the Biometric Exit Program. The Request ... Protection (CBP), explains that CBP intends to add biometrics ... the United States , in order to deter ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/9/2016)...  Perkotek an innovation leader in attendance control systems is proud to announce the ... employers to make sure the right employees are actually signing in, and to even ... ... ... ...
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016  The Prostate Cancer Foundation ... increasingly precise treatments and faster cures for prostate cancer. Members of the Class ... across 15 countries. Read More About the Class of ... ... ...
(Date:6/23/2016)... ... , ... Supplyframe, the Industry Network for electronics hardware design ... Located in Pasadena, Calif., the Design Lab’s mission is to bring together inventors ... and brought to market. , The Design Lab is Supplyframe’s physical representation of ...
(Date:6/23/2016)... Apellis Pharmaceuticals, Inc. today announced positive ... its complement C3 inhibitor, APL-2. The trials were ... studies designed to assess the safety, tolerability, pharmacokinetics ... healthy adult volunteers. Forty subjects were ... dose (ranging from 45 to 1,440mg) or repeated ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the NASDAQ Composite ... Jones Industrial Average edged 0.27% lower to finish at 17,780.83; ... has initiated coverage on the following equities: Infinity Pharmaceuticals Inc. ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... more about these stocks by accessing their free trade alerts ...
Breaking Biology Technology: