Navigation Links
Nanoparticles for delivery of prostate cancer treatment

Alan Garen, professor of molecular biophysics and biochemistry at Yale has received a $100,000 award from the Prostate Cancer Foundation to expand research on the delivery of a targeted therapy for prostate cancer using nanoparticles.

Garen and his collaborator Zhiwei Hu have developed a way to directly target and destroy the blood vessels of solid tumors, thus destroying the tumors while leaving normal tissue unharmed.

The technology uses a synthetic gene encoding an antibody-like molecule that activates an immune response to destroy the tumor blood vessels and associated tumors.

Garen previously received grants from the National Cancer Institute and Breast Cancer Alliance for Icon projects. The grant from the Prostate Cancer Foundation will extend his research to prostate cancer, which is the most common non-skin cancer in the United States.

Prostate cancer strikes one in six men. In 2007 alone, more than 200,000 men will be diagnosed with prostate cancer and more than 25,000 men will die of the disease. As the Baby Boomer generation begins to turn 60, increasing numbers of men are in the highest-risk sector for the disease. Over the next decade, the number of new cases is expected to increase to more than 300,000 annually.

The molecule that Garen and Hu constructed, called an Icon, recognizes the receptor tissue factor (TF) found on cells lining the inner surface of blood vessels in tumors but not in normal tissues. The Icon binds to TF more strongly and specifically than a natural antibody. Because the Icon acts through the blood, it can reach metastatic tumors throughout the body, which is critical for effective cancer therapy.

With the Prostate Foundation funding Garen will test the efficacy and safety of using targeted liposomal nanoparticle vectors ?lipid-covered, gene deli
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Imaging Lymph Nodes with Nanoparticles
3. Probing The Promise And Perils Of Nanoparticles
4. Nanoparticles offer new hope for detection and treatment
5. Nanoparticles carry cancer-killing drugs into tumor cells
6. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
7. Nanoparticles can track cells deep within living organisms
8. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk
9. New methods of gene delivery using lasers
10. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
11. Self-assembled DNA buckyballs for drug delivery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nanoparticles for delivery prostate cancer treatment

(Date:7/24/2014)... own microbial terroir, meaning the microbial populations found on ... product, creating the final flavor according to research published ... Environmental Microbiology . This is the first time investigators ... , Many sake makers inoculate with both bacteria ... the University of California, Davis, but he and his ...
(Date:7/24/2014)... vision specialist at The University of Texas Health Science ... a grant to help Harris County residents whose vision ... , Even with corrective lenses, many people with low ... a variety of low vision devices, such as telescopes, ... loss. , Iyer is using the three-year, $164,645 SightFirst ...
(Date:7/24/2014)... hotspot of biodiversity and one of the most species ... the world. However, current levels of diversity might be ... an increase in the description of new endemic species ... techniques and availability of samples for DNA analysis. ... molecular and morphological analysis, researchers from the University ...
Breaking Biology News(10 mins):The microbes make the sake brewery 2UTHealth Dr. Bhavani Iyer awarded low vision grant 2A tiny new species of frog from Brazil with a heroic name 2
... battle to reduce carbon emissions is at the heart ... of Missouri have discovered that nature has been lending ... in the Department of Forestry discovered that trees submerged ... years, a significantly longer period of time than trees ...
... grew wild in Mexico and were radically different from ... important crops in the world. While the ... Mexico, the time and location of the earliest domestication ... Now, in addition to more traditional macrobotanical and archeological ...
... A detailed analysis of data from nearly 50 ... adjacent Rhode Island Sound has revealed a long-term shift ... effects of global warming. According to Jeremy Collie, ... Graduate School of Oceanography, the fish community has shifted ...
Cached Biology News:Ancient oak trees help reduce global warming 2Early origins of maize in Mexico 2Early origins of maize in Mexico 3Climate change causing significant shift in composition of coastal fish communities 2Climate change causing significant shift in composition of coastal fish communities 3
(Date:7/24/2014)... PRINCETON, N.J. , July 24, 2014 /PRNewswire/ ... largest provider of regulatory and ethical review services ... acquired Alliance Biosciences. Formerly a division of ... Biosciences was the leading biosafety and biosecurity consulting ... . With this addition, WCG,s biosafety division – ...
(Date:7/24/2014)... July 24, 2014  Spherix Incorporated (SPEX) -- an ... monetization of intellectual property, today announced that the Company ... June 30, 2014 on Monday, August 18, 2014 for ... a.m. ET on Monday, August 18, 2014 to discuss ... the company,s CEO, Anthony Hayes . ...
(Date:7/23/2014)... , July 24, 2014 Lyfebulb, the ... Inc. (OTCQX and NASDAQ OMX First North Premier, ... "the Company"), announced a collaboration to increase awareness ... night at an event attended by more than ... Lyfebulb is a health and wellness company dedicated ...
(Date:7/23/2014)... (MIPT and Russian Quantum Center at Skolkovo) and ... and the Institute of Physics in Bratislava, Slovakia) ... of particles passing through an amplifier and, conversely, ... are provided in an article published in the ... , Quantum entangled particles are considered to be ...
Breaking Biology Technology:WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Spherix Schedules Shareholder Update Call 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 2Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 3Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 4Innovative Collaboration To Increase Awareness Of Bullous Pemphigoid, A Rare Autoimmune Disease Of The Skin 5Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4
... Nov. 9, 2011 NewCardio, Inc., (OTC BB: NWCI) ... strategic partner, Clinilabs, will utilize QTinno®, NewCardio,s automated cardiac ... an investigational new drug under development for a central ... will be one important aspect of the trial. ...
... 9, 2011 Rhythm, a biotechnology company developing peptide ... Keith M. Gottesdiener, MD, as Chief Executive Officer. Dr. ... he served as Vice President and Late-Stage Therapeutic Group ... in all therapeutic areas, and previously as head of ...
... data-intensive biomedical and genetic research -- is now ... of researchers including Anton Nekrutenko, an associate professor ... University; Kateryna Makova, an associate professor of biology ... University, developed the new technology, which will help ...
Cached Biology Technology:Clinilabs will Conduct Phase 1 Trial Using QTinno® 2Clinilabs will Conduct Phase 1 Trial Using QTinno® 3Clinilabs will Conduct Phase 1 Trial Using QTinno® 4Clinilabs will Conduct Phase 1 Trial Using QTinno® 5Rhythm Names Keith M. Gottesdiener Chief Executive Officer 2Galaxy DNA-analysis software is now available 'in the cloud' 2Galaxy DNA-analysis software is now available 'in the cloud' 3
... for imaging of chemiluminescent, fluorescent and colorimetric ... control for users who wish to change ... A range of high resolution, cooled cameras ... and chemiluminescent applications , Interchangeable filters ...
... features a 4.1 mega pixel digital color ... TLC color images., The cabinet features ... longwave UV tubes positioned on two sides ... fluorescence studies , Interior overhead white ...
Request Info...
... ICE-LAP3 Mch3 Lyophilized ... of enzyme regulation and kinetics, cleavage of target substrates, ... units/mg protein. One unit is defined as ... of Ac-DEVD-pNA Cat. No. 235400 per hour at 37 ...
Biology Products: