Navigation Links
Nanoparticle assembly enters the fast lane

The speed of nanoparticle assembly can be accelerated with the assistance of the molecule that carries life's genetic instructions, DNA, a team of researchers at the U.S. Department of Energy's Brookhaven National Laboratory recently found. Nanoparticles, particles with dimensions on the order of billionths of a meter, could potentially be used for more efficient energy generation and data storage, as well as improved methods for diagnosing and treating disease. Learning how to control and tailor the assembly of these miniscule particles into larger functional systems remains a major challenge for scientists. The Brookhaven results, published online on October 11, 2006, by the Journal of the American Chemical Society, are a step in that direction.

"Understanding how to self-assemble these types of nanomaterials has applications in all areas of nanotechnology, from optics to electronics to magnetic materials," said the study's lead author Mathew Maye, a Brookhaven chemist. Maye is part of a team of interdisciplinary scientists from Brookhaven's new Center for Functional Nanomaterials (CFN) and the biology department. The researchers found a way to control the assembly of gold nanoparticles using rigid, double-stranded DNA. Their technique takes advantage of this molecule's natural tendency to pair up components called bases, known by the code letters A, T, G and C.

"In biology, DNA is mainly an informational material, while in nanoscience, DNA is an excellent structural material due to its natural ability to self-assemble according to well-specified programmable rules," said Oleg Gang, the Brookhaven physicist who leads the research team. "Using biological materials such as DNA, we are developing approaches to control the assembly of inorganic nano-objects. However, in order to really turn this attractive approach into nanotechnology, we have to understand the complexity of interaction in such hybrid systems."

The synthetic DNA used in th e laboratory is capped onto individual gold nanoparticles and customized to recognize and bind to complementary DNA located on other particles. This process forms clusters, or aggregates, of gold particles.

"It's really by design," Maye said. "We can sit down with a piece of paper, write out a DNA sequence, and control how these nanoparticles will assemble."

One limitation to the assembly process is the use of single-stranded DNA, which can bend backward and attach to the particle's gold surface instead of binding with surrounding nanoparticles. This flexibility, along with the existence of multiple forms of single-stranded DNA, can greatly slow the assembly process. In the Brookhaven study, researchers introduced partially rigid, double-stranded DNA, which forces interacting linker segments of DNA to extend away from the gold surface, allowing for more efficient assembly.

"By using properties of DNA, we can increase assembly kinetics, or speed, by relatively simple means without a lot of synthetic steps," Maye said.

The research team probed the synthesized and assembled nanosystems with multiple imaging techniques, using beams of light and electrons as well as high-intensity x-rays at Brookhaven's National Synchrotron Light Source. The scientists look to further improve the controllability of the system, focusing next on the size of the nanoparticle clusters.
'"/>

Source:DOE/Brookhaven National Laboratory


Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Imaging Lymph Nodes with Nanoparticles
3. Taking Aim With Nanoparticle PEBBLEs
4. Probing The Promise And Perils Of Nanoparticles
5. Nanoparticles offer new hope for detection and treatment
6. Nanoparticle Breast Cancer Drug Approved by FDA
7. Nanoparticles carry cancer-killing drugs into tumor cells
8. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
9. Nanoparticles for delivery of prostate cancer treatment
10. Nanoparticles can track cells deep within living organisms
11. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... 2016 Research and Markets has ... Market 2016-2020,"  report to their offering.  , ... ,The global gait biometrics market is expected to ... period 2016-2020. Gait analysis generates multiple ... used to compute factors that are not or ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... ... 29, 2016 , ... Proove Biosciences, Inc ., the ... launch of the Proove Health Foundation . The Foundation is a non-profit ... use of personalized medicine for tackling the nation’s most-pressing healthcare epidemics. As part ...
(Date:4/29/2016)... ... ... Intelligent Implant Systems announced today that the two-level components for the Revolution™ Spinal System ... These components expand the capabilities of the system and allow Revolution™ to be utilized ... the company has seen significant sales growth in 1Q 2016, and the system is ...
(Date:4/28/2016)... ... April 28, 2016 , ... Next ... a talk on its first-in-class technologies for tissue stem cell counting and expansion ... RNAiMicroRNA Biology to Reprogramming & CRISPR-based Genome Engineering in Burlington, Massachusetts. , The ...
(Date:4/27/2016)... ... April 27, 2016 , ... The Pittcon Organizing Committee is pleased to ... been a volunteer member of Committee since 1987. Since then, he has served in ... treasurer and was chairman for both the program and exposition committees. In his professional ...
Breaking Biology Technology: