Navigation Links
Nanoparticle assembly enters the fast lane

The speed of nanoparticle assembly can be accelerated with the assistance of the molecule that carries life's genetic instructions, DNA, a team of researchers at the U.S. Department of Energy's Brookhaven National Laboratory recently found. Nanoparticles, particles with dimensions on the order of billionths of a meter, could potentially be used for more efficient energy generation and data storage, as well as improved methods for diagnosing and treating disease. Learning how to control and tailor the assembly of these miniscule particles into larger functional systems remains a major challenge for scientists. The Brookhaven results, published online on October 11, 2006, by the Journal of the American Chemical Society, are a step in that direction.

"Understanding how to self-assemble these types of nanomaterials has applications in all areas of nanotechnology, from optics to electronics to magnetic materials," said the study's lead author Mathew Maye, a Brookhaven chemist. Maye is part of a team of interdisciplinary scientists from Brookhaven's new Center for Functional Nanomaterials (CFN) and the biology department. The researchers found a way to control the assembly of gold nanoparticles using rigid, double-stranded DNA. Their technique takes advantage of this molecule's natural tendency to pair up components called bases, known by the code letters A, T, G and C.

"In biology, DNA is mainly an informational material, while in nanoscience, DNA is an excellent structural material due to its natural ability to self-assemble according to well-specified programmable rules," said Oleg Gang, the Brookhaven physicist who leads the research team. "Using biological materials such as DNA, we are developing approaches to control the assembly of inorganic nano-objects. However, in order to really turn this attractive approach into nanotechnology, we have to understand the complexity of interaction in such hybrid systems."

The synthetic DNA used in th e laboratory is capped onto individual gold nanoparticles and customized to recognize and bind to complementary DNA located on other particles. This process forms clusters, or aggregates, of gold particles.

"It's really by design," Maye said. "We can sit down with a piece of paper, write out a DNA sequence, and control how these nanoparticles will assemble."

One limitation to the assembly process is the use of single-stranded DNA, which can bend backward and attach to the particle's gold surface instead of binding with surrounding nanoparticles. This flexibility, along with the existence of multiple forms of single-stranded DNA, can greatly slow the assembly process. In the Brookhaven study, researchers introduced partially rigid, double-stranded DNA, which forces interacting linker segments of DNA to extend away from the gold surface, allowing for more efficient assembly.

"By using properties of DNA, we can increase assembly kinetics, or speed, by relatively simple means without a lot of synthetic steps," Maye said.

The research team probed the synthesized and assembled nanosystems with multiple imaging techniques, using beams of light and electrons as well as high-intensity x-rays at Brookhaven's National Synchrotron Light Source. The scientists look to further improve the controllability of the system, focusing next on the size of the nanoparticle clusters.
'"/>

Source:DOE/Brookhaven National Laboratory


Related biology news :

1. DNA Molecules Used To Assemble Nanoparticles
2. Imaging Lymph Nodes with Nanoparticles
3. Taking Aim With Nanoparticle PEBBLEs
4. Probing The Promise And Perils Of Nanoparticles
5. Nanoparticles offer new hope for detection and treatment
6. Nanoparticle Breast Cancer Drug Approved by FDA
7. Nanoparticles carry cancer-killing drugs into tumor cells
8. Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
9. Nanoparticles for delivery of prostate cancer treatment
10. Nanoparticles can track cells deep within living organisms
11. Cancer tip -- Nanoparticles can damage DNA, increase cancer risk

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2016)... , June 20, 2016 Securus ... justice technology solutions for public safety, investigation, corrections ... the prisons involved, it has secured the final ... (DOC) facilities for Managed Access Systems (MAS) installed. ... additional facilities to be installed by October, 2016. ...
(Date:6/7/2016)... June 7, 2016  Syngrafii Inc. and San ... relationship that includes integrating Syngrafii,s patented LongPen™ eSignature ... This collaboration will result in greater convenience for ... union, while maintaining existing document workflow and compliance ... ...
(Date:6/1/2016)... , June 1, 2016 Favorable ... Election Administration and Criminal Identification to Boost Global Biometrics ... recently released TechSci Research report, " Global Biometrics Market ... Competition Forecast and Opportunities, 2011 - 2021", the global ... by 2021, on account of growing security concerns across ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
(Date:6/23/2016)... LOUISVILLE, Ky. , June 23, 2016 /PRNewswire/ ... from two Phase 1 clinical trials of its ... double-blind, placebo-controlled, single and multiple ascending dose studies ... and pharmacodynamics (PD) of subcutaneous injection in healthy ... APL-2 subcutaneously (SC) either as a single dose ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
(Date:6/23/2016)... , June 23, 2016 ... research report to its pharmaceuticals section with historic ... details and much more. Complete report ... 151 pages, profiling 15 companies and supported with ... http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The Global ...
Breaking Biology Technology: