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Nano-particles effective in killing cancer with one-two punch of chemotherapeutics

is water-soluble, stays within the interior of the polymersome until it degrades. According to the researchers, the polymersome and drug combination is self-assembling ?the structure spontaneously forms when all of the components are suitably mixed together.

"Recent studies have shown that cocktails of paclitaxel and doxorubicin lead to better tumor regression than either drug alone, but there hasn't been any carrier system that can carry both drugs as efficiently to a tumor," said Fariyal Ahmed, the lead author, former doctoral student in bioengineering,and now a fellow at Harvard Medical School. "Polymersomes get around those limitations".

Discher developed polymersomes with Penn bioengineer Daniel Hammer in the 1990s. The Discher lab is further studying the drug- and gene-delivery capabilities of polymersomes, tailoring their shapes, sizes, loading and degradability to each application. Discher theorizes that polymersomes could be made capable of traveling to places in the body that are difficult for most drug-carrier systems to access.


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Source:University of Pennsylvania


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