Navigation Links
NYU study reveals how brain's immune system fights viral encephalitis

New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brain.

"There is no magic bullet in fighting viral infections in neurons," said NYU Biology Professor Carol Shoshkes Reiss, the study's senior author. "However, these findings show the redundancy of the immune system--when one response fails to fight infection, others step in."

The study was also conducted at NYU, by a post-doctoral fellow, Mark Trottier, Jr., PhD, now at Michigan State, and Beth Palian, currently a doctoral student at the University of Southern California.

Recently, the West Nile virus has been responsible for a viral encephalitis outbreak in the northeast. The NYU researchers set out to determine how the body can fight viral encephalitis. Specifically, they examined how type I interferons--proteins made by the body that are released in response to stimuli, notably infection--work in neurons and to determine if nerve cells' response to interferons is similar to that of other cells.

Examining the effect of the virus in mice and in cell culture, the researchers found that neurons are sensitive to the protective effect of interferons, inducing pathways to fight the virus' spread. However, their findings showed that interferons fight the virus at different stages of the virus' life cycle. First, they inhibit viral RNA and protein synthesis. If this fails, interferons block the virus from forming particles which can be released and infect other neurons. This is critical, since the immune system does not kill infected precious neurons the way it does other cells, which can be replaced.

The researchers attributed the spread of vi ral encephalitis to the inability of lab mice to produce sufficient amounts of interferons to fight the virus.


'"/>

Source:New York University


Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/27/2018)... ... November 27, 2018 , ... Earthres Group, ... as Chief Operating Officer (COO). Dave joins the executive leadership team at ... internal functions. Dave will also serve in a key strategic role by ...
(Date:11/27/2018)... ... November 27, 2018 , ... Victrex has ... solution with a broader range of usage temperature compared to existing polymers such ... its new VICTREX CT™ 200 for dynamic sealing applications where gases such as ...
(Date:11/23/2018)... ... November 23, 2018 , ... ... Mayer, MD, Executive Director of the G. Oppenheimer Center for Neurobiology of Stress ... and doctors from around the world, Dr. Mayer will bring to uBiome his ...
Breaking Biology News(10 mins):
(Date:11/20/2018)... ... November 20, 2018 , ... Each year Forbes receives thousands of ... which highlights outstanding performance by individuals under 30 years of age. The Forbes 30 ... from Sports and Entertainment to Venture Capital and Science. , In 2017, Visikol ...
(Date:11/13/2018)... Springs, GA (PRWEB) , ... November 12, 2018 ... ... dentist with state-of-the-art practices in Alpharetta and Sandy Springs, now welcomes new ... aligners provide a discreet and comfortable alternative to traditional braces in the Sandy ...
(Date:11/9/2018)... ... November 08, 2018 , ... uBiome, the leader ... Executive Officer and President of Andes Biotechnologies, to its Scientific Advisory Board. Joining ... brings to uBiome expertise on the genetic studies of hepatitis viruses. The appointment ...
(Date:11/6/2018)... ... November 06, 2018 , ... Crucial Data Solutions announces the ... management. TrialKit ™, an eClinical platform, has incorporated Apple’s biometric technologies for ... sign in to the app via facial recognition or fingerprint recognition. , ...
Breaking Biology Technology: