Navigation Links
NYU biologists map out early stages of embryo formation

A team of genomic researchers headed by biologists at New York University's Center for Comparative Functional Genomics, in collaboration with researchers at Harvard University, the Max Planck Institute, and Cenix Biosciences, has mapped out a preliminary molecular diagram of the early stages of embryo formation, offering for the first time a global look at how a single cell begins its path into a multi-cellular organism. The findings are reported in the August 11 issue of the journal Nature.

The team is studying the function of the genome of Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop.

With the complete genome sequence of C. elegans, the researchers sought to comprehend how the parts encoded by the genome are used to build complex dynamical biological systems--in this case, an engineering diagram for embryo formation. Using a new way to combine results from different functional genomic approaches including RNA interference (RNAi), a method for studying the function of genes in vivo, the researchers were able to develop a first-draft diagram for the early embryo at the molecular level, describing how its components fit together both physically and logically.

"These results point to a high level of coordination among a relatively small number of molecular machines required for proper early embryonic development in C. elegans," said Fabio Piano, an assistant professor in NYU's Department of Biology, who headed the research team. "This may also be the case for human embryogenesis. The diagrams linking all these genes reveal discrete patterns of interconnections, allowing us to begin to visualize the molecular network underlying a complex process like early embryogenesis as a whole."

These analyses suggest that out of the almost 20,000 genes in C. elegans, the embryo requires a core set of less than 1,000 genes to coordinate the early e vents that guide the development of the animal. The results further suggest specific roles for new genes that had not been studied before, and functional tests of a subset of these supported the predictions.

Describing how embryos function at the molecular level may help understand how human embryos develop, and may also provide new insights for cancer research since genes acting in early embryogenesis are often erroneously reactivated in cancer cells.

The research is the latest in a series of studies conducted at NYU's Center for Comparative Functional Genomics in collaboration with researchers at Harvard and Yale Universities, which set the stage for these most recent findings. An essential aspect of these studies was the coordination between experts in cell and molecular biology and those with computational and mathematical backgrounds.


'"/>

Source:New York University


Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. FSU biologists describe key role of signal-transcribing gene during cell cycle
4. High-tech tags on marine animals yield valuable data for biologists and oceanographers
5. UCSD biologists find new evidence for one-way evolution
6. UC San Diego biologists solve plant growth hormone enigma
7. FSU biologists uncover mechanisms that shape cells for better or worse
8. NYU biologists identify gene that coordinates two cellular processes
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/21/2016)... 22, 2016 Unique technology ... for superior security   Xura, ... of secure digital communications services, today announced it is ... offer enterprise customers, particularly those in the Financial Services ... voice authentication within a mobile app, alongside, and in ...
(Date:3/15/2016)... , March 15, 2016 --> ... published by Transparency Market Research "Digital Door Lock Systems Market ... 2015 - 2023," the global digital door lock systems market ... in 2014 and is forecast to grow at a CAGR ... micro, small and medium enterprises (MSMEs) across the world and ...
(Date:3/14/2016)... , Allemagne, March 14, 2016 ... ) - --> - Renvoi : image ... --> --> ... biométriques, fournit de nouveaux lecteurs d,empreintes digitales pour ... de DERMALOG sera utilisé pour produire des cartes ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... ... 2016 , ... Doctors in Italy say mesothelioma patients with the highest levels ... levels. Surviving Mesothelioma has just posted an article on the new research. Click ... La Spezia, Italy tested the blood serum, tumors, and lung fluid of 45 ...
(Date:5/31/2016)... ... May 31, 2016 , ... The Academy of Model Aeronautics is thrilled ... on display Memorial Day through Labor Day 2016. Bill Chaffee’s Boeing P-12B will be ... , Bill Chaffee won first place for Senior Scale Model at the 1930 National ...
(Date:5/27/2016)... ... May 27, 2016 , ... Weeks after hosting a ... Phoenix, Dr. Michael Fitzmaurice, hand surgeon and founder of the Fitzmaurice Hand Institute, has ... Wrist MRI machine is a state-of-the-art technology and only 1 of about 3 currently ...
(Date:5/27/2016)... ... ... Doctors in Italy, Japan, the UK and the US have reached some surprising ... its link to malignant mesothelioma. Surviving Mesothelioma has just posted the details of their ... , The studies analyzed for the new report included more than 3,447 cancer patients. ...
Breaking Biology Technology: