Navigation Links
NYU biologists map out early stages of embryo formation

A team of genomic researchers headed by biologists at New York University's Center for Comparative Functional Genomics, in collaboration with researchers at Harvard University, the Max Planck Institute, and Cenix Biosciences, has mapped out a preliminary molecular diagram of the early stages of embryo formation, offering for the first time a global look at how a single cell begins its path into a multi-cellular organism. The findings are reported in the August 11 issue of the journal Nature.

The team is studying the function of the genome of Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop.

With the complete genome sequence of C. elegans, the researchers sought to comprehend how the parts encoded by the genome are used to build complex dynamical biological systems--in this case, an engineering diagram for embryo formation. Using a new way to combine results from different functional genomic approaches including RNA interference (RNAi), a method for studying the function of genes in vivo, the researchers were able to develop a first-draft diagram for the early embryo at the molecular level, describing how its components fit together both physically and logically.

"These results point to a high level of coordination among a relatively small number of molecular machines required for proper early embryonic development in C. elegans," said Fabio Piano, an assistant professor in NYU's Department of Biology, who headed the research team. "This may also be the case for human embryogenesis. The diagrams linking all these genes reveal discrete patterns of interconnections, allowing us to begin to visualize the molecular network underlying a complex process like early embryogenesis as a whole."

These analyses suggest that out of the almost 20,000 genes in C. elegans, the embryo requires a core set of less than 1,000 genes to coordinate the early e vents that guide the development of the animal. The results further suggest specific roles for new genes that had not been studied before, and functional tests of a subset of these supported the predictions.

Describing how embryos function at the molecular level may help understand how human embryos develop, and may also provide new insights for cancer research since genes acting in early embryogenesis are often erroneously reactivated in cancer cells.

The research is the latest in a series of studies conducted at NYU's Center for Comparative Functional Genomics in collaboration with researchers at Harvard and Yale Universities, which set the stage for these most recent findings. An essential aspect of these studies was the coordination between experts in cell and molecular biology and those with computational and mathematical backgrounds.


'"/>

Source:New York University


Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. FSU biologists describe key role of signal-transcribing gene during cell cycle
4. High-tech tags on marine animals yield valuable data for biologists and oceanographers
5. UCSD biologists find new evidence for one-way evolution
6. UC San Diego biologists solve plant growth hormone enigma
7. FSU biologists uncover mechanisms that shape cells for better or worse
8. NYU biologists identify gene that coordinates two cellular processes
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... ANGELES , June 22, 2016 /PRNewswire/ ... identity management and verification solutions, has partnered ... edge software solutions for Visitor Management, Self-Service ... provides products that add functional enhancements ... partnership provides corporations and venues with an ...
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... has awarded the 44 million US Dollar project, ... Security Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... world leader in the production and implementation of Identity Management ... in January, however Decatur was selected ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the ... at the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application ... team,” said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our ...
(Date:6/23/2016)... June 23, 2016 Apellis Pharmaceuticals, Inc. ... clinical trials of its complement C3 inhibitor, APL-2. ... multiple ascending dose studies designed to assess the ... subcutaneous injection in healthy adult volunteers. ... as a single dose (ranging from 45 to ...
(Date:6/23/2016)... 2016 Andrew D ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
Breaking Biology Technology: