Navigation Links
NYU biologists identify gene that coordinates two cellular processes

A team of biologists at New York University's Center for Comparative Functional Genomics has uncovered a dual role for the gene mel-28. The gene plays a part in ensuring that chromosomes are divided properly during cell division and it is required for nuclear envelope function. The findings appear in the journal Current Biology.

The team is using functional genomic tools to study the nematode worm Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop. The study appearing in Current Biology was performed by NYU's Fabio Piano, an assistant professor, and Anita Fernandez, a post-doctoral researcher, at the Center for Comparative Functional Genomics.

Biologists can draw connections between genes based on systematically accumulated experimental evidence. Network diagrams that illustrate such connections show that most genes fall into highly interconnected groups called modules. These modules are often enriched for genes that share the same role. In order to determine the functions of genes whose role is unknown, researchers examine genes in the same module whose function has already been discovered. This approach has proven useful for learning about the roles of unknown genes.

Unlike most genes in the network, mel-28 had connections to two distinct modules. Piano and Fernandez tested the idea that mel-28 plays important roles in both chromosome segregation and nuclear envelope function. Part of this undertaking included examining the protein MEL-28, which the gene mel-28 encodes.

By fusing mel-28 to a gene-encoding GFP, a fluorescent marker, and expressing this fusion in early embryos, they visualized the movement of MEL-28 during cell division in living embryos. Consistent with the idea that MEL-28 had function in chromosome segregation and the nuclear envelope, the MEL-28-GFP fusion was observed to shuttle between the nuclear periphe ry and the chromosomes during cell division. Additional functional tests showed that mel-28 was essential to both the integrity of the nuclear envelope and to proper chromosome segregation. This study served as a validation of network modeling as a means to identify genes that coordinate multiple functions.


'"/>

Source:New York University


Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. NYU biologists map out early stages of embryo formation
4. FSU biologists describe key role of signal-transcribing gene during cell cycle
5. High-tech tags on marine animals yield valuable data for biologists and oceanographers
6. UCSD biologists find new evidence for one-way evolution
7. UC San Diego biologists solve plant growth hormone enigma
8. FSU biologists uncover mechanisms that shape cells for better or worse
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... Research and Markets has announced ... 2016-2020"  report to their offering.  , ,     (Logo: ... analysts forecast the global multimodal biometrics market to ... period 2016-2020.  Multimodal biometrics is being ... the healthcare, BFSI, transportation, automotive, and government for ...
(Date:4/15/2016)... -- Research and Markets has announced the ...  report to their offering.  ,      ... gait biometrics market is expected to grow at ... Gait analysis generates multiple variables such ... compute factors that are not or cannot be ...
(Date:3/31/2016)...   LegacyXChange, Inc. ... LegacyXChange is excited to release its first ... be launched online site for trading 100% guaranteed authentic ... also provide potential shareholders a sense of the value ... industry that is notorious for fraud. The video is ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016   EpiBiome , a precision ... million in debt financing from Silicon Valley Bank (SVB). ... and to advance its drug development efforts, as well ... "SVB has been an incredible strategic partner ... a traditional bank would provide," said Dr. Aeron ...
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... ... 23, 2016 , ... ClinCapture, the only free validated electronic ... showcase its product’s latest features from June 26 to June 30, 2016 for ... Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug Information ...
(Date:6/23/2016)... June 23, 2016 ReportsnReports.com ... report to its pharmaceuticals section with historic and ... and much more. Complete report on ... pages, profiling 15 companies and supported with 261 ... http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The Global Cell ...
Breaking Biology Technology: