Navigation Links
NYU biologists identify gene that coordinates two cellular processes

A team of biologists at New York University's Center for Comparative Functional Genomics has uncovered a dual role for the gene mel-28. The gene plays a part in ensuring that chromosomes are divided properly during cell division and it is required for nuclear envelope function. The findings appear in the journal Current Biology.

The team is using functional genomic tools to study the nematode worm Caenorhabditis elegans (C. elegans), the first animal species whose genome was completely sequenced and a model organism to study how embryos develop. The study appearing in Current Biology was performed by NYU's Fabio Piano, an assistant professor, and Anita Fernandez, a post-doctoral researcher, at the Center for Comparative Functional Genomics.

Biologists can draw connections between genes based on systematically accumulated experimental evidence. Network diagrams that illustrate such connections show that most genes fall into highly interconnected groups called modules. These modules are often enriched for genes that share the same role. In order to determine the functions of genes whose role is unknown, researchers examine genes in the same module whose function has already been discovered. This approach has proven useful for learning about the roles of unknown genes.

Unlike most genes in the network, mel-28 had connections to two distinct modules. Piano and Fernandez tested the idea that mel-28 plays important roles in both chromosome segregation and nuclear envelope function. Part of this undertaking included examining the protein MEL-28, which the gene mel-28 encodes.

By fusing mel-28 to a gene-encoding GFP, a fluorescent marker, and expressing this fusion in early embryos, they visualized the movement of MEL-28 during cell division in living embryos. Consistent with the idea that MEL-28 had function in chromosome segregation and the nuclear envelope, the MEL-28-GFP fusion was observed to shuttle between the nuclear periphe ry and the chromosomes during cell division. Additional functional tests showed that mel-28 was essential to both the integrity of the nuclear envelope and to proper chromosome segregation. This study served as a validation of network modeling as a means to identify genes that coordinate multiple functions.


'"/>

Source:New York University


Related biology news :

1. Octopuses occasionally stroll around on two arms, UC Berkeley biologists report
2. GeneNotes - A novel information management software for biologists
3. NYU biologists map out early stages of embryo formation
4. FSU biologists describe key role of signal-transcribing gene during cell cycle
5. High-tech tags on marine animals yield valuable data for biologists and oceanographers
6. UCSD biologists find new evidence for one-way evolution
7. UC San Diego biologists solve plant growth hormone enigma
8. FSU biologists uncover mechanisms that shape cells for better or worse
9. MIT biologists solve vitamin puzzle
10. Yale biologists trick viruses into extinction
11. Brown cancer biologists identify major player in cell growth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/6/2017)... 6, 2017 Forecasts by Product ... Readers, by End-Use (Transportation & Logistics, Government & Public ... & Fossil Generation Facility, Nuclear Power), Industrial, Retail, Business ... Are you looking for a definitive report on ... ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... Los Angeles, CA (PRWEB) , ... ... ... Pharmaceuticals, Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) ... all uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed ...
(Date:10/10/2017)... research firm Parks Associates announced today that Tom Kerber ... Annual Meeting , October 11 in Scottsdale, Arizona . ... how smart safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... 13 prestigious awards honoring scientists who have made outstanding contributions ... scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for laboratory ...
(Date:10/9/2017)... N.C. (PRWEB) , ... October 09, 2017 , ... At ... announced Dr. Christopher Stubbs, a professor in Harvard University’s Departments of Physics and Astronomy, ... Stubbs was a member of the winning team for the 2015 Breakthrough Prize in ...
Breaking Biology Technology: