Navigation Links
NYU and MSKCC research provides model for understanding chemically induced cancer initiation

A team from the chemistry and biology departments of New York University, in collaboration with Memorial Sloan Kettering Cancer Center (MSKCC), has uncovered a conformational switch--a change in shape in a carcinogen-damaged DNA site--in tumor suppressor genes altered by a known cancer-causing chemical found in cigarette smoke. This finding may open new horizons for understanding the initiation of chemically induced cancers.

The findings appear as the cover story in the latest issue of the Journal of Molecular Biology. This team was headed by Dinshaw Patel at MSKCC, Nicholas Geacintov, chair of NYU's chemistry department, and Suse Broyde, a professor in NYU's biology department.

The studied gene, p53, is an important tumor suppressor gene that plays critical roles in cellular functions such as cell-cycle control, differentiation, and DNA repair. Many different chemical carcinogens, including those that are primary components of cigarette smoke, are known to damage DNA. This damage occurs at special positions of the p53 gene, called mutation hot spots, which have been previously linked with cigarette smoke. This molecular link between chemical DNA damage and cigarette-associated lung cancer has been called the "smoking gun."

In the study, the conformational switch discovered by the research team entails a change in the conformation of a carcinogen-damaged site in a DNA model sequence similar to that in a p53 mutation hot spot. The change is brought about by the presence of a single methyl group (composed only of one carbon and three hydrogen atoms) on a cytosine base adjacent to the damaged site. Without this methyl group, the bulky chemical carcinogen resides at an external binding site in the minor groove of the DNA double helix. However, in the presence of this single methyl group, it assumes an intercalated structure in which the carcinogenic residue is sandwiched between adjacent base pairs in the double helix.

"Such conformational
'"/>

Source:New York University


Page: 1 2

Related biology news :

1. MSKCC researchers uncover structure of key protein complex in cells
2. Columbia research lifts major hurdle to gene therapy for cancer
3. U of M researcher examines newly emerging deadly disease
4. NYU researchers simulate molecular biological clock
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. New research questions basic tenet of neuron function
7. Vital step in cellular migration described by UCSD medical researchers
8. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
9. UCSD researchers maintain stem cells without contaminated animal feeder layers
10. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
11. New protein discovered by Hebrew University researchers
Post Your Comments:
(Date:8/25/2015)... CITY and BELLEVUE, Wash. ... leader in advanced robotic systems, announced today it will ... unmanned ground vehicle (UGV), at the National Tactical Officers ... The Guardian S is the first-ever ... culmination of years of research and in-field trials and ...
(Date:8/20/2015)... The wearable technology market has traditionally ... healthy. However, wearable technology has the potential to ... improve diagnostic capabilities and therapeutic outcomes. Today, Leaf ... Technologies Conference 2015 , where Barrett Larson ... healthcare.    "Over the past decade, ...
(Date:8/19/2015)... , Aug. 19, 2015  VOXX International Corporation ... has entered into a Definitive Agreement to purchase ... iris authentication market leader EyeLock through an acquiring ... have a controlling interest in the acquiring entity. ... completion of due diligence.  Expanding on its existing ...
Breaking Biology News(10 mins):Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5
... CHAMPAIGN, Ill. University of Illinois researchers are using ... weightiest questions in biology the relationship between cell mass ... computer engineering and bioengineering professor Rashid Bashir, published its results ... the National Academy of Sciences . "It,s merging micro-scale ...
... , LA JOLLA, CA-Fisetin, a naturally occurring compound ... slows the onset of motor problems and delays ... to researchers at the Salk Institute for Biological ... of Human Molecular Genetics , sets the ...
... ovarian cancer but new research from the Centenary Institute has ... new way that can break the resistance mechanism. Published ... (FTY720) had a potent effect in human ovarian cancer cells, ... chemotherapeutic drug currently available for the treatment of ovarian cancer. ...
Cached Biology News:Microsensors offer first look at whether cell mass affects growth rate 2Natural compound shows promise against Huntington's disease 2Natural compound shows promise against Huntington's disease 3New treatment to overpower drug resistance in ovarian cancer 2
(Date:8/26/2015)... ... 2015 , ... MediVet Biologics, a leader in Veterinary Regenerative ... open in Manhattan, Kansas in early October, 2015. The location of the lab ... development through collaboration with researchers from Kansas State University’s College of Veterinary Medicine. ...
(Date:8/26/2015)... , Aug. 26, 2015  The Diabetes ... the University of Miami Miller School of Medicine, ... clinical trial to test for the first time ... successfully completed.  This FDA approved Phase I/II study ... transplantation and is an important first step toward ...
(Date:8/26/2015)... China Cord Blood Corporation (NYSE: CO ... provider of cord blood collection, laboratory testing, hematopoietic stem ... that the Company has been informed that Magnum Opus ... by Mr. Yuen Kam, chairman of the board of ... (the "Shares") of  Excellent China Healthcare Investment Limited ("KKR ...
(Date:8/26/2015)... ... ... The 2015 Epigenomics & Metabolomics Meeting in Boston was an ideal ... share the first report on progress with its crowdsourcing campaign designed to evaluate rapidly ... , With a name like “H2A.Z asymmetry,” the new biomarker would require detailed explication ...
Breaking Biology Technology:MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 2MediVet Biologics Animal Health Secures Additional Laboratory Facility in Manhattan, Kansas 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 2China Cord Blood Corporation Receives Notice of Transactions Regarding its 7% Senior Convertible Notes Due 2017 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 2Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 3Asymmetrex Reports Positive Indicators for Crowdsourcing Campaign to Evaluate New Biomarker for Counting Adult Tissue Stem Cells for the First Time 4
... Christine Lawless, MD, has accepted the position as Medical ... medical education (CME), beginning March 2, 2009. Recognized as ... cardiology, Dr. Lawless recently completed her clinical tenure at ... she was Associate Professor of Internal Medicine and Co-Director ...
... March 10 SeqWright, a world-wide leader in custom ... has been granted a California clinical laboratory license. ... and Single Nucleotide Polymorphism (SNP) Genotyping expertise in order ... a significant step forward in the shift towards personalized ...
... American Pacific Corporation (Nasdaq: APFC ) is ... Chemicals LLC (AFC), located near Sacramento California, recently inaugurated ... The new facility can accommodate either batch reactors (20 ... using up to 7 reactors from 0.25 to 1 ...
Cached Biology Technology:Former President of Sports Cardiology Consultants, LLC Christine Lawless, MD, MBA, ABCL, FACC, FACSM, Named Medical Director of CME Enterprise 2California Grants SeqWright License to Operate as a Clinical Laboratory 2AMPAC Fine Chemicals Announces the Inauguration of the New cGMP Continuous Processing Development Facility 2
... consist of seven reduced, denatured proteins (equine ... rabbit muscle GAPDH, bovine muscle actin, BSA, ... ranging from 4.5 to 8.5 and molecular ... 2-D standards provide calibrated references for the ...
The sealed ice cooling unit is used to absorb heat that is generated during transfers performed in the Criterion blotter....
StemSep Anti-Phycoertherin Tetrameric Antibody Complexes, 2 mL for labeling 1x10 9 cells. Cross-linking Reagent for StemSep Separations of Cells Labeled with PE-conjugated Antibody....
4',6-Diamidino-2-phenylindole, dihydrochloride (DAPI)...
Biology Products: