Navigation Links
NYU Study Reveals How Brain's Immune System Fights Viral Encephalitis

New York University biologists have uncovered how the innate immune system in mice's brains fights viral infection of neurons. The findings, published as the cover study in the latest issue of Virology, show that proteins in neurons fight the virus at multiple stages--by preventing the formation of viral RNA and proteins, and blocking the virus' release, which could infect other cells in the brain.

"There is no magic bullet in fighting viral infections in neurons," said NYU Biology Professor Carol Shoshkes Reiss, the study's senior author. "However, these findings show the redundancy of the immune system--when one response fails to fight infection, others step in."

The study was also conducted at NYU, by a post-doctoral fellow, Mark Trottier, Jr., PhD, now at Michigan State, and Beth Palian, currently a doctoral student at the University of Southern California.

Recently, the West Nile virus has been responsible for a viral encephalitis outbreak in the northeast. The NYU researchers set out to determine how the body can fight viral encephalitis. Specifically, they examined how type I interferons--proteins made by the body that are released in response to stimuli, notably infection--work in neurons and to determine if nerve cells' response to interferons is similar to that of other cells.

Examining the effect of the virus in mice and in cell culture, the researchers found that neurons are sensitive to the protective effect of interferons, inducing pathways to fight the virus' spread. However, their findings showed that interferons fight the virus at different stages of the virus' life cycle. First, they inhibit viral RNA and protein synthesis. If this fails, interferons block the virus from forming particles which can be released and infect other neurons. This is critical, since the immune system does not kill infected precious neurons the way it does other cells, which can be replaced.

The researchers attributed the spread of vi ral encephalitis to the inability of lab mice to produce sufficient amounts of interferons to fight the virus.


'"/>

Source:New York University


Related biology news :

1. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
2. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
3. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
4. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
5. Study Links Ebola Outbreaks To Animal Carcasses
6. Breakthrough Microarray-based Technology for the Study of Cancer
7. Study finds more than one-third of human genome regulated by RNA
8. Leukemia Drug Breakthrough Study In New England Journal Of Medicine
9. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
10. New Study from Affymetrix Laboratories Points to Changing View of How Genome Works
11. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... SUNNYVALE, Calif. , April 18, 2017  Socionext Inc., a ... prototype of a media edge server, the M820, which features the ... face recognition software provided by Tera Probe, Inc., will be showcased ... and at the NAB show at the Las Vegas ... ...
(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... No two people are believed to ... York University Tandon School of Engineering and Michigan ... partial similarities between prints are common enough that ... and other electronic devices can be more vulnerable ... in the fact that fingerprint-based authentication systems feature ...
Breaking Biology News(10 mins):
(Date:4/25/2017)... ... 25, 2017 , ... L3 Clinical Trials, the Clinical Research ... now a certified iMedNet eClinical and Electronic Data Capture software designer for clinical ... team to build, customize and manage clinical trial data capture and databases for ...
(Date:4/25/2017)... SEATTLE, WA (PRWEB) , ... April 25, 2017 , ... ... technology division of Quorum, will be featured in multiple sessions at this week’s ... range from emerging trends to best practices in clinical research. , "We are excited ...
(Date:4/21/2017)... ... 21, 2017 , ... Having worked on the design of the innovative ... it to top lab design architects from around the country at the Lab Design ... Design and Engineering Greg Casey will be at the show, where they will highlight ...
(Date:4/21/2017)... ... , ... Frederick Innovative Technology Center, Inc. (FITCI), a business ... start-ups, is hosting “Celebration Friday” (a festive gathering highlighting client success stories) and ... networking at 3:30 p.m. at FITCI’s 4539 Metropolitan Court location, off English Muffin ...
Breaking Biology Technology: