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NIH renews network focused on how genes influence drug responses

hared information library for pharmacogenetics research. To protect the privacy of research study participants, names and other identifying information are not stored in this knowledge base. (Russ B. Altman, M.D., Ph.D., Stanford University School of Medicine)

  • Pharmacogenetics of Nicotine Addiction and Treatment--$10 million provided by NIDA, NIGMS, and NCI for a multicenter, interdisciplinary program to examine the genetic basis for individual variation in response to medications for treating tobacco dependence. (Neal L. Benowitz, M.D., University of California, San Francisco)

  • Consortium on Breast Cancer Pharmacogenomics--$11.6 million provided by NIGMS, NIEHS, and ORWH to investigate how genetic differences explain variable responses to tamoxifen and hormone treatments frequently prescribed to treat breast cancer. (David A. Flockhart, M.D., Ph.D., Indiana University School of Medicine)

  • The Pharmacogenetics of Membrane Transporters--$15 million provided by NIGMS, NCI, and NIMH to study how drug response is affected by variability in the genes for "gatekeeper" molecules called membrane transporters, which interact with up to a third of the most commonly used prescription drugs. (Kathleen M. Giacomini, Ph.D., University of California, San Francisco)

  • Pharmacogenomic Evaluation of Antihypertensive Responses--$11.1 million provided by NIGMS to identify which genes play a role in people's widely variable responses to high blood pressure drugs. (Julie A. Johnson, Pharm.D., University of Florida in Gainesville)

  • Pharmacogenetics and Risk of Cardiovascular Disease--$14.8 million
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    • Source:NIH/National Institute of General Medical Sciences


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