Navigation Links
NIDA study identifies genes that might help some people abstain from smoking

Scientists supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have for the first time identified genes that might increase a person’s ability to abstain from smoking. The breakthrough research was conducted by Dr. George Uhl at NIDA’s Intramural Research Program and a team led by Dr. Jed Rose at the Center for Nicotine and Smoking Cessation Research at Duke University Medical Center.

The study, published in the journal BMC Genetics, available on line April 2, brings researchers a step closer toward tailoring individualized drug therapy for addiction based on an individual’s unique genetic makeup.

“This research marks the first time we’ve been able to identify genes involved in the ability to quit smoking,?says NIDA Director Dr. Nora D. Volkow. “It marks a movement from identifying the genetics of addiction vulnerability to identifying the genetic basis of successful abstinence. This knowledge could impact the success rate of cessation programs by helping health care providers choose the most appropriate treatment based on individual differences.?

Dr. Uhl and his colleagues performed a genome-wide analysis on the DNA of two types of nicotine-dependent individuals, one that was able to successfully quit the cigarette- smoking behavior and one that was not.

“We identified 221 genes that distinguished successful quitters from those who were unsuccessful,?says Dr. Uhl. “We know the functions of about 187 of these genes, but 34 have functions that are unknown at present. We also found that at least 62 of the genes that we had previously identified as playing roles in dependence to other drugs also contribute to nicotine dependence.?

Genes that harbor variants that contribute to both success in quitting smoking and in vulnerability to become dependent on multiple substances include cadherin 13 (a molecule involved in cell adhesion, which governs how cells recognize and connect t
'"/>

Source:NIH/National Institute on Drug Abuse


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
(Date:7/24/2008)...-- A single typhoon in Taiwan buries as much carbo...l the other rains in that country all year long co...niversity study published in a recent issue of the...r to examine the chemistry of stream water and sed...yphoon was happening at full force -- will help sc...
(Date:7/23/2008)...stock manure into a domestic renewable fuel source...hree per cent of North America,s entire consumptio...enhouse gas emissions (GHGs), according to US rese...stitute of Physics, Environmental Research Letter...and Emissions Benefits of Converting Manure to Bio...
(Date:7/23/2008)... Wealthy nations willing to collectively spend abo...of roughly half a billion metric tons of carbon di... suggests. , It would take about that much mone...tation in the world, one of the top contributors t..., If adopted, this type of program could have po...
(Date:7/23/2008)...ummit" will bring together internationally renowne..., Russia, China, Japan, Australia and India to ad... Aug. 2. , "We are bringing together the worl... said summit organizer J. William Schopf, founder ...nd Planetary Physics, Center for the Study of Evol...
Breaking Biology News(10 mins):Study: Typhoons bury tons of carbon in the oceans 2Study: Typhoons bury tons of carbon in the oceans 3Study: Typhoons bury tons of carbon in the oceans 4Cow power could generate electricity for millions 2Paying to save tropical forests could be a way to reduce global carbon emissions 2Paying to save tropical forests could be a way to reduce global carbon emissions 3Paying to save tropical forests could be a way to reduce global carbon emissions 4UCLA 'world summit' to explore ancient life on Earth, and beyond 2Obesity research boosted by watching hunger in the brain 5751 1Obesity research boosted by watching hunger in the brain 5751 2FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change 1141 1FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change 1141 2FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change 1141 3FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change 1141 4FIJI Water announces sustainable growth initiative with commitment to help mitigate climate change 1141 5Engineered weathering process could mitigate global warming 1138 1Engineered weathering process could mitigate global warming 1138 2Engineered weathering process could mitigate global warming 1138 3Good Hygiene Is Key to Preventing MRSA 5748 1Good Hygiene Is Key to Preventing MRSA 5748 2
...ing documentary, showed how the emperor penguins e...bitterly cold months each year. The tight huddling...aving mechanism that allows them to endure their e... that had already shown that emperor penguins who ...rcent of their time in dense huddles and drop thei...
...excited receptors in the brain, say neuroscientist..., Alzheimer,s and other neurodegenerative diseases... Southern California, his graduate student Wei Xu ...olumbia outline their technique in the Feb. 1 issu...tory mice with a decoy peptide containing a snippe...
...shock or stroke could be based on a protein that i...rticle to be published in the November issue of Th...e describe this protein, which may be the key to u...d improve recoveries for patients. , The Italian r... the brain,s response to oxygen deprivation and pl...
... evidence yet that sudden infant death syndrome (S... biological basis. In the November 1 issue of JAMA...nt abnormalities in the brainstem ?a part of the b...y heat, and arousal ?in babies who died from SIDS....n infants after the newborn period, affecting 0.67...
Other Biology News:Huddling and a drop in metabolism allow penguins to survive the South Pole cold 2Huddling and a drop in metabolism allow penguins to survive the South Pole cold 3Huddling and a drop in metabolism allow penguins to survive the South Pole cold 4Decoy pill saves brain cells 2A potential biological cause for sudden infant death syndrome 2A potential biological cause for sudden infant death syndrome 3
(Date:7/25/2008)...Newswire/ -- BioTrends Research Group, Inc.,releas...M) publication, a,syndicated report offering compr...ia and bone and mineral metabolism in Chronic Kidn... information from 182 US,Nephrologists -- data wer...ne 2008., In the renal anemia market, while the u...
(Date:7/25/2008)...X, CALGARY, July 25 / Resv...X:RVX) is pleased to announce effective,immediatel...irectors. On,the subject of her appointment Jan Gr...xciting opportunity for me. The Company has done a...linical trials. I expect the next,foreseeable futu...
(Date:7/25/2008)...swire-FirstCall/ -- Caraco Pharmaceutical,Laborato...first quarter of,Fiscal 2009, ended June 30, 2008,...or the corresponding period of Fiscal 2008. This r...er of Fiscal 2008. Pre-tax income grew,to $14.6 mi...ared to a,pre-tax income of $9.6 million during th...
(Date:7/25/2008)...25 /- REvolution Computing will,lead ...R product at the,upcoming BioC 2008 conference in ... REvolution Computing Director of Community, Dr. D... Training Manager, and Martin Morgan of,the Fred H...ting,s BioC lab,will introduce participants to the...
Breaking Biology Technology:BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 2BioTrends Releases Quarterly TreatmentTrends(TM): Nephrology Report Highlighting Market Trends for Renal Anemia, Hyperphosphatemia, and Secondary Hyperparathyroidism 3Jan Gray Joins Resverlogix Board of Directors 2Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 2Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 3Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 4Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 5Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 6Caraco Pharmaceutical Laboratories, Ltd. Reports Results for the First Quarter of Fiscal Year 2009 7REvolution Computing Offers Hands-On Tutorial of NWS Parallel Computing Environment at BioC 2008 2
...r and commercialization efforts are on the rise in...the Medical College of Wisconsin to intensify its ...opment Corporation (MDC) and the Center for Adva...d a new partnership designed to increase private i...e Energies is also helping to increase technology ...
... , announced today they have signed a distribution...ndependent distributor of advanced clinical in-vit...he companys distribution agreement announced last ...he same goal; to create innovative solutions that ...ico,s highly skilled team provides specialized dia...
...ulty at the University of Wisconsin-Eau Claire are...pportunities to work on research relating to mater...sity to assist local industries. , ,UW-Eau Claires...rt research, facilitate collaboration among scienc... between the university and local industries, and ...
... States are concerned with the increasing trade im... down and begin the process of leveling the playin... for them! , ,As developing nations rush to play ... are often doled out as favors, to friends in high...easons. This occurred in Japan during the 1990s an...
Other Biology Technology:Madison Development Corp. and CATI form tech transfer partnership 2UW-Eau Claire creates Materials Science Center 2UW-Eau Claire creates Materials Science Center 3How do you level the playing field with China? 2How do you level the playing field with China? 3
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi
Mouse monoclonal antibody to RNase L
Anti (porcine) Vitronectin
Rabbit polyclonal to BMP2 BMP2 belongs to the transforming growth factor beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant
Biology Products: