Navigation Links
NIDA study identifies genes that might help some people abstain from smoking

Scientists supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have for the first time identified genes that might increase a person’s ability to abstain from smoking. The breakthrough research was conducted by Dr. George Uhl at NIDA’s Intramural Research Program and a team led by Dr. Jed Rose at the Center for Nicotine and Smoking Cessation Research at Duke University Medical Center.

The study, published in the journal BMC Genetics, available on line April 2, brings researchers a step closer toward tailoring individualized drug therapy for addiction based on an individual’s unique genetic makeup.

“This research marks the first time we’ve been able to identify genes involved in the ability to quit smoking,?says NIDA Director Dr. Nora D. Volkow. “It marks a movement from identifying the genetics of addiction vulnerability to identifying the genetic basis of successful abstinence. This knowledge could impact the success rate of cessation programs by helping health care providers choose the most appropriate treatment based on individual differences.?

Dr. Uhl and his colleagues performed a genome-wide analysis on the DNA of two types of nicotine-dependent individuals, one that was able to successfully quit the cigarette- smoking behavior and one that was not.

“We identified 221 genes that distinguished successful quitters from those who were unsuccessful,?says Dr. Uhl. “We know the functions of about 187 of these genes, but 34 have functions that are unknown at present. We also found that at least 62 of the genes that we had previously identified as playing roles in dependence to other drugs also contribute to nicotine dependence.?

Genes that harbor variants that contribute to both success in quitting smoking and in vulnerability to become dependent on multiple substances include cadherin 13 (a molecule involved in cell adhesion, which governs how cells recognize and connect t
'"/>

Source:NIH/National Institute on Drug Abuse


Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. W.M. Keck Foundation funds study of friendly microbes
3. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
4. Genome-wide mouse study yields link to human leukemia
5. Clam embryo study shows pollutant mixture adversely affects nerve cell development
6. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
7. Same mutation aided evolution in many fish species, Stanford study finds
8. Sequencing of marine bacterium will help study of cell communication
9. Genetically modified rice in China benefits farmers health, study finds
10. A new study examines how shared pathogens affect host populations
11. NYU study reveals how brains immune system fights viral encephalitis
Post Your Comments:
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ...
(Date:12/10/2014)... , Dec. 9, 2014 CIE San Diego has launched ... connective tissue that enhances care coordination among social service and ... earned a second $1 million grant from the Alliance Healthcare ... and; will be recognized as a "Live Well San Diego" ...
(Date:12/10/2014)...     Jifflenow to ...   Jifflenow, a leading provider of ... (B2B) events, today announced a partnership with ITN ... (NFC), Bluetooth low energy (BLE), and cloud-based event ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... Thanksgiving, when you bite into the cranberry sauce and the ... from your sister, consider the power of sour.,Neurobiology researchers at ... about how some cells respond to sour tastes. Of ... umami sour is arguably the strongest yet the least ...
... HawaiiIn collaboration with Stanford University and the University ... Southwest Research Station,s Institute of Pacific Islands Forestry ... ecosystems"a mix of native and non-native speciesin an ... forests. The research team, comprised of Dr. ...
... HARBOR, N.Y. (Nov. 23, 2010) -- Specialized white blood ... immunity--helping the body to identify and eliminate "non-self" substances such ... and B cells occurs when immunoreceptors on the cell surface ... This binding activates signaling pathways inside the T cells ...
Cached Biology News:Sour research, sweet results 2US Forest Service and 2 universities team up to develop new ecosystems for Hawaiian forests 2
(Date:1/22/2015)... January 22, 2015 Pipette.com has added ... to their comprehensive portfolio of Eppendorf products. , The ... purchase a Centrifuge 5424/5424 R and receive the following:, ... Eppendorf Research plus or Eppendorf Reference 2 , ...
(Date:1/22/2015)... 2015 Controlled Substance Compliance Services (CSCS), ... companies check the legal requirements around using controlled substances ... , As their international operations expand and become ... solutions built as a result of the first phase ...
(Date:1/22/2015)... Jersey , 22 de enero de 2015  El Dr. ... hoy su llamada a nominaciones para 2015. Este prestigioso ... hecho, o tiene el potencial para hacer, contribuciones destacadas ... se aceptarán hasta el 15 de marzo de 2015 ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2
... VANCOUVER, Aug. 13 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals, Inc. (NASDAQ: ... received approval to begin marketing the Quill(TM) SRS Polydioxanone (PDO), ... are very excited about the approval of the Quill SRS ... in the world. Quill has been lauded in the U.S., ...
... , CARLSBAD, Calif., Aug. 13 ... provider, today announced the Company,s participation at the 2009 Southern California ... Newport Beach, CA on August 18, 2009. , ... Genoptix, will present at the conference on that Tuesday, beginning at ...
... in Teddington have developed imaging technology to be used in ... an impending labour shortage for UK farmers. Annual waste ... can mean up to 100,000 of lost revenue for an ... during research. Falling number of migrant labourers means that healthy ...
Cached Biology Technology:Angiotech receives approval for Quill(TM) SRS PDO, MONODERM(TM), Polypropylene and Nylon product lines for sale in Brazil 2Angiotech receives approval for Quill(TM) SRS PDO, MONODERM(TM), Polypropylene and Nylon product lines for sale in Brazil 3Angiotech receives approval for Quill(TM) SRS PDO, MONODERM(TM), Polypropylene and Nylon product lines for sale in Brazil 4Genoptix Announces Participation at the 2009 Southern California Investor Conference 2UK scientists developing intelligent harvesting robot to save farms up to 100,000 a year 2
Flotillin-2 (ESA) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 29, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
... Product Rabbit polyclonal to Kv4.2 ... to KLH, corresponding to amino acids 23-43 ... Cross-reacts with Rat.Expected to cross-react with ... identity with immunogen), Rabbit (100% identity with ...
Human Presenilin-2 NTF Affinity Purified Polyclonal Ab...
Human/Rat Neurogenin-2 MAb (Clone 7G4) Protein Family: Neural Crest Cell Markers, Transcription Factors...
Biology Products: