Navigation Links
NIAID begins clinical trial of West Nile virus vaccine

A small trial testing the safety of an experimental vaccine targeting West Nile virus (WNV) opened today at the National Institutes of Health's (NIH) Clinical Center in Bethesda, MD. The vaccine, which will be tested first in 15 healthy adult volunteers, was developed for human clinical studies by researchers at the National Institute of Allergy and Infectious Diseases' (NIAID) Vaccine Research Center (VRC), and Vical Inc., San Diego, based on an animal vaccine tested at the Centers for Disease Control and Prevention (CDC). Vical also manufactures the experimental vaccine.

"Although the prevalence of West Nile virus disease fluctuates seasonally and regionally, it continues to pose a serious public health threat, especially to older adults and people with weakened immune systems," says Anthony S. Fauci, M.D., director of the NIAID.

WNV, initially isolated in Uganda in 1937, made its first U.S. appearance in New York City in 1999. The virus usually is transmitted to humans through the bite of a mosquito that has been infected after feeding on an infected bird or animal. The virus also can be spread through blood transfusions, organ transplants and breastfeeding, as well as from mother to child during pregnancy. Most people experience no symptoms or only mild symptoms, such as fever, headache and body aches; more serious cases can lead to infections of the brain and nervous system, such as encephalitis or meningitis. In 2004, 2,470 cases of WNV disease were reported in the United States, resulting in 88 deaths. Currently, no WNV vaccine is licensed for use in humans.

The experimental vaccine is composed of a small, circular piece of DNA--called a DNA plasmid--that contains genes that code for two key surface proteins of the West Nile virus. When the vaccine is injected into the muscle, the inner machinery of the muscle cells "reads" the DNA and converts it into two WNV proteins. Recognizing that the proteins are foreign, the muscle cells display them on their surface to alert the body's immune system--both helper T cells, which spur the production of antibodies to block the WNV from gaining entry into cells, and killer T cells, which kill WNV-infected cells outright.

"The DNA vaccine's exploitation of both cellular and antibody immunity offers a potentially potent defense against West Nile virus," says Barney Graham, M.D., Ph.D., chief of the VRC's Clinical Trials Core Laboratory. Adds Dr. Graham, "In our experience in clinical trials, DNA vaccines generally cause few side effects, making them a promising alternative to conventional vaccines."

Although no DNA vaccine has yet been licensed, other DNA vaccines developed by the VRC against HIV/AIDS, Ebola and SARS also are being tested in ongoing trials at NIH.

Fifteen healthy volunteers between the ages of 18 and 50 will receive three injections of the DNA vaccine into the upper arm: one at the start of the trial, a second approximately four weeks later, and a third approximately four weeks after that. To help force the DNA plasmid into muscle cells, the vaccine will be administered by a needle-free injector rather than a conventional needle syringe. Volunteers will be monitored for possible symptoms or side effects as well as the body's ability to generate WNV-specific antibodies and T cells. The vaccine cannot cause West Nile virus infection or disease because it does not contain infectious material from the virus. For more information on the WNV vaccine trial, call the Vaccine Research Center's toll free number 1-866-833-LIFE, or visit the VRC Web site

The vaccine in this study builds upon an experimental vaccine developed by CDC researcher Jeff Chang, D.V.M., Ph.D., of Fort Collins, CO, that has been tested successfully in a variety of animals, including mice, horses and American crows.

Two other human WNV vaccines developed with NIAID support are currently i n Phase I clinical trials. Called chimeric vaccines, these vaccines combine genes of the West Nile virus with genes of a closely related virus--yellow fever virus in the case of a vaccine developed by Acambis, Cambridge, MA, and dengue virus in the case of a vaccine developed by NIAID intramural researchers.



Related biology news :

1. NIAID Initiates Trial of Experimental Avian Flu Vaccine
2. New NIAID grants strengthen national biodefense and emerging infectious diseases research network
3. NIAID researchers show how promising TB drug works
4. NIAID DNA vaccine for H5N1 avian influenza enters human trial
5. NIAID expands capability for influenza research and surveillance
6. International trial of two microbicides begins
7. Wyoming cloud seeding experiment begins this month
8. Cancer scientists create human leukemia process to map how disease begins, progresses
9. Roche clinical trial registry and results database launched
10. Compound might defeat African sleeping sickness, clinical trial beginning this month
11. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
Post Your Comments:

(Date:11/18/2015)... 18, 2015 --> ... new market report titled  Gesture Recognition Market - Global ... - 2021. According to the report, the global gesture recognition market was ... to reach US$29.1 bn by 2021, at a CAGR ... North America dominated the global gesture recognition ...
(Date:11/16/2015)... Calif. , Nov 16, 2015  Synaptics ... of human interface solutions, today announced expansion of ... TouchView ™ touch controller and display driver ... revolution of smartphones. These new TDDI products add ... TD4100 (HD resolution), TD4302 (WQHD resolution), and TD4322 ...
(Date:11/10/2015)... 10, 2015  In this report, the ... of product, type, application, disease indication, and ... report are consumables, services, software. The type ... biomarkers, efficacy biomarkers, and validation biomarkers. The ... diagnostics development, drug discovery and development, personalized ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... - ProMetic Life Sciences Inc. (TSX: PLI) (OTCQX: PFSCF) ("ProMetic" ... , President and Chief Executive Officer of ProMetic, will be ... th Annual Healthcare Conference to be held at the ... st , at 8.50am (ET) and ProMetic,s management team ... presentation will be available live via a webcast accessible at ...
(Date:11/24/2015)... ... ... Whitehouse Laboratories is pleased to announce that it has completed construction on a ... basic USP 61, USP 62 and USP 51 testing specific to raw materials and ... testing performed by one supplier. Management has formally announced that the facility ...
(Date:11/23/2015)... , ... November 23, 2015 , ... ... for the development of its Nexera UC Unified Chromatography system. The award from ... technically significant new products of the year in the analytical and testing category. ...
(Date:11/23/2015)... , Nov. 23, 2015  CryoLife, Inc. (NYSE: CRY ... on cardiac and vascular surgery, announced today that it will ... Healthcare Conference on Wednesday, December 2, 2015 at The New ... . Pat Mackin , President and Chief Executive ... Chief Executive Officer. --> A live webcast ...
Breaking Biology Technology: