Navigation Links
NIAID begins clinical trial of West Nile virus vaccine

A small trial testing the safety of an experimental vaccine targeting West Nile virus (WNV) opened today at the National Institutes of Health's (NIH) Clinical Center in Bethesda, MD. The vaccine, which will be tested first in 15 healthy adult volunteers, was developed for human clinical studies by researchers at the National Institute of Allergy and Infectious Diseases' (NIAID) Vaccine Research Center (VRC), and Vical Inc., San Diego, based on an animal vaccine tested at the Centers for Disease Control and Prevention (CDC). Vical also manufactures the experimental vaccine.

"Although the prevalence of West Nile virus disease fluctuates seasonally and regionally, it continues to pose a serious public health threat, especially to older adults and people with weakened immune systems," says Anthony S. Fauci, M.D., director of the NIAID.

WNV, initially isolated in Uganda in 1937, made its first U.S. appearance in New York City in 1999. The virus usually is transmitted to humans through the bite of a mosquito that has been infected after feeding on an infected bird or animal. The virus also can be spread through blood transfusions, organ transplants and breastfeeding, as well as from mother to child during pregnancy. Most people experience no symptoms or only mild symptoms, such as fever, headache and body aches; more serious cases can lead to infections of the brain and nervous system, such as encephalitis or meningitis. In 2004, 2,470 cases of WNV disease were reported in the United States, resulting in 88 deaths. Currently, no WNV vaccine is licensed for use in humans.

The experimental vaccine is composed of a small, circular piece of DNA--called a DNA plasmid--that contains genes that code for two key surface proteins of the West Nile virus. When the vaccine is injected into the muscle, the inner machinery of the muscle cells "reads" the DNA and converts it into two WNV proteins. Recognizing that the proteins are foreign, the muscle cells display
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. NIAID Initiates Trial of Experimental Avian Flu Vaccine
2. New NIAID grants strengthen national biodefense and emerging infectious diseases research network
3. NIAID researchers show how promising TB drug works
4. NIAID DNA vaccine for H5N1 avian influenza enters human trial
5. NIAID expands capability for influenza research and surveillance
6. International trial of two microbicides begins
7. Wyoming cloud seeding experiment begins this month
8. Cancer scientists create human leukemia process to map how disease begins, progresses
9. Roche clinical trial registry and results database launched
10. Compound might defeat African sleeping sickness, clinical trial beginning this month
11. Neurologix announces positive results of gene therapy clinical trial in Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: NIAID begins clinical trial West Nile virus vaccine

(Date:5/19/2015)... , May 19, 2015  Technology is rapidly ... internally and in the cloud. Passwords and their management ... of OTP and standards-based specifications such as those developed ... outmoded use of passwords presents for BYOD, COPE, IoT, ... unified biometric identity protocol. In response ...
(Date:5/11/2015)... , May 11, 2015  Synaptics Incorporated (NASDAQ: ... interface solutions, today announced the appointment of ... Chief Financial Officer, reporting to Rick Bergman ... current Chief Financial Officer, Kathleen Bayless , ... Mr. Ali brings extensive financial management ...
(Date:5/7/2015)... , May 7, 2015 ... fingerprint sensors, FPC1022 and FPC1035, FPC,s smallest touch ... FPC1035 are mainly considered for integration on the ... gives smartphone OEMs increased possibilities to integrate touch ... decreased size also improves possibilities for module manufacturers ...
Breaking Biology News(10 mins):HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2FPC Introduces its Smallest Touch Fingerprint Sensors to Date 2
... the recent opening of its new Biomolecular Labeling Laboratory, ... become one of a small handful of facilities in ... different isotopes to make them easier to analyze. The ... those in biomedical fields who also want to take ...
... one can create a field of science out of thin ... bold concept. But for the emerging field of sustainability ... of potentially divergent theory, practice and policy, the gamble has ... Proceedings of the National Academy of Sciences , scientists from ...
... killing countless coral reefs around the world can now be ... researchers say. Coral researchers and reef managers will be ... allows them to classify specific diseases based on the presence ... to reduce the impact of disease on the world,s imperilled ...
Cached Biology News:Tags? We're it. NIST opens new 'biolabeling' research facility 2Is sustainability science really a science? 2Scientific sleuths pinpoint the guilty coral killers 2
(Date:6/2/2015)... -- GOJO, inventors of PURELL ® Advanced Hand ... the White House Forum.  GOJO was among 150 major ... at the White House Forum to announce commitments over ... antibiotic-resistant bacteria, detect resistant strains, preserve the efficacy of ... infections. "A primary prevention approach to reduce ...
(Date:6/2/2015)... June 2, 2015 MGB ... antibiotic resistance problem  MGB Biopharma, a ... anti-infectives, to address the major global problem of ... a stable intravenous (IV) formulation of MGB-BP-3, designed for ... infections.  The intravenous formulation of MGB-BP-3 ...
(Date:6/2/2015)... 02, 2015 GenoCAD , a ... improve protein expression, announced the formation of its new ... and entrepreneurs with a broad range of experience in ... The team includes: , Jimmy Roussel, Entrepreneur in Residence ... a background in technology and marketing. He has served ...
(Date:6/1/2015)... , June 1, 2015  Turing Pharmaceuticals ... Eliseo Oreste Salinas , MD, MSc,  has joined ... Dr. Salinas, who holds a medical ... brings a record of significant accomplishments in the ... Dr. Salinas has played a leadership ...
Breaking Biology Technology:GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 2GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 3GOJO Among Leaders At The White House Forum On Antibiotic Stewardship 4MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 2MGB Biopharma Succeeds in Developing an IV Formulation of MGB-BP-3 for the Treatment of Systemic Susceptible and Resistant Gram-Positive Hospital-Acquired Infections 3GenoCAD Announces New Board of Advisors, Improves Protein Expression Using Custom Gene Synthesis 2GenoCAD Announces New Board of Advisors, Improves Protein Expression Using Custom Gene Synthesis 3Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 2Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 3
... Boston University engineers have designed cells that can count and ... of genes are activated in a specific order. , Such ... used to count the number of times a cell divides, ... also serve as biosensors that count exposures to different toxins. ...
... with unique QTRAP(R) technologyMONTREAL, May 28 Caprion ... with Applied Biosystems, a division of Life Technologies ... the verification and validation of protein biomarker candidates ... is extending its leadership in mass spectrometry-based biomarker ...
... general health and self-care management by using simple tools ... May 28 Roche, the maker of ACCU-CHEK(R) blood ... availability of two new tools that can help patients ... impact on their blood glucose levels, giving them greater ...
Cached Biology Technology:MIT, BU engineer cellular circuits that count events 2MIT, BU engineer cellular circuits that count events 3Caprion Proteomics Inc. and Applied Bioystems Work Together to Accelerate Protein Biomarker Verification and Validation 2Caprion Proteomics Inc. and Applied Bioystems Work Together to Accelerate Protein Biomarker Verification and Validation 3Caprion Proteomics Inc. and Applied Bioystems Work Together to Accelerate Protein Biomarker Verification and Validation 4Roche Announces Back-to-Basics Approach to Diabetes Care - Simpler is Better 2Roche Announces Back-to-Basics Approach to Diabetes Care - Simpler is Better 3
High voltage electrophoresis power supply...
Rab GDP dissociation inhibitor beta...
The Programmable MP-3500P-F Power Supply can be applied for any Microfluidic application....
BD BioCoat Collagen IV 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of mouse collagen type IV....
Biology Products: