( ared a single-celled ancestor. This pr...)NHGRI announces latest sequencing targets

ared a single-celled ancestor. This project targets ten of the earliest branches of animals and fungi along with some of their single-celled relatives providing, for the first time, comprehensive data to fill gaps in our understanding of animal and fungal evolution. Recent research has shown that some genes in the human genome that are responsible for early animal development arose much earlier than thought, in some cases in single-celled organisms. Therefore, this set of ten targets is likely to reveal the origins of other genes important for multi-cellularity in all such animals, including humans. The ten targets, all of which involve relatively small genomes, include six to be sequenced at high-density genome coverage: Capsaspora owczarzak; Sphaeroforma arctica; an Amastigomonas species; a Salpingoeca or Codosiga species; Allomyces macrogynus; and Nucleria simplex; and four to be sequenced at low-density genome coverage: Amoebidium parasiticum; Mortierella verticillata; Spizellomyces punctatus; and a Stephanoeca or Acanthocoepis species.

NHGRI's Large-Scale Sequencing Research Network also includes a portfolio of medical sequencing projects. These projects are designed to use high-throughput sequencing resources to lead to significant medical advances. As more is learned from sequencing and other studies about the genomic contribution to disease, and as the cost of obtaining sequence information decreases, genomic sequence information will become ever more important both for medical research and for providing medically relevant information to individuals. When it becomes affordable for an individual's genome to be fully sequenced, genomic information will allow estimates of future disease risk for individuals, as well as improve prevention, diagnosis and treatment.

Projects given the highest priority will use large-scale sequencing over the next few years to identify the genes responsible for dozens of relatively rare,
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Source:NIH/National Human Genome Research Institute

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