NHGRI aims to make DNA sequencing faster, more cost effective ( to tailor an alternative protein pore ...)

NHGRI aims to make DNA sequencing faster, more cost effective

to tailor an alternative protein pore, Mycobacterium smegmatis porin A (MspA), for nanopore sequencing.

"$100,000 Genome" Grants

NHGRI's "Near-Term Development for Genome Sequencing" grants will support research aimed at sequencing a human-sized genome at 100 times lower cost than is possible today. There is strong potential that, in less than five years, several of these technologies will be at or near commercial availability. Grant recipients in the current cycle and their approximate total funding are:

Michael L. Metzker, Ph.D., Human Genome Sequencing Center, Baylor College of Medicine, Houston,$500,000 (1 year),"Ultrafast SBS (Sequencing by Synthesis) Method for Large-Scale Human Resequencing"

This team has developed a novel type of fluorescent nucleotide that is modified for sequencing by synthesis. Their goal is to improve the chemical subunits, called reversible terminators, for use in a system that will ultimately be used to sequence DNA templates in high-density arrays, using a sensitive fluorescence detection system.

Steven Jeffrey Gordon, Ph.D., Intelligent Bio-Systems, Inc., Worcester, Mass.,$425,000 (1 year),"High-Throughput DNA Sequencing by Synthesis Platform"

The main goal of this project is to develop a high-speed, massively parallel DNA sequencing system using unique base analogues and the sequencing by synthesis approach, in collaboration with a group at Columbia University. This application is focused on the development of the subsystems required to construct high-density sample arrays on glass chips and to run sequencing by synthesis reactions on them in an automated, high-throughput fashion.

Source:NIH/National Human Genome Research Institute

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( to tailor an alternative protein pore ...)NHGRI aims to make DNA sequencing faster, more cost effective