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NHGRI aims to make DNA sequencing faster, more cost effective

make it feasible to sequence a genome for $1,000, as well as two investigators developing "near term" technologies to sequence a genome for $100,000. Both approaches have many complementary elements that integrate biochemistry, chemistry and physics with engineering to enhance the whole effort to develop the next generation of DNA sequencing and analysis technologies. Since 2004, NHGRI has awarded $83 million to investigators to develop both "near term" and revolutionary sequencing technologies.

"It is very important that we encourage and support the development of innovative sequencing technologies. Many of these new approaches have shown significant promise, yet far more exploration and development are needed if they are to be useful to the average researcher or physician," said Jeffery Schloss, Ph.D., NHGRI's program director for technology development. "We look forward to seeing which of these technologies fulfill their promise and achieve the quantum leaps that are needed to take DNA sequencing to the next level."

"$1,000 Genome" Grants

NHGRI's "Revolutionary Genome Sequencing Technologies" grants have as their goal the development of breakthrough technologies that will enable a human-sized genome to be sequenced for $1,000 or less. Grant recipients and their approximate total funding are:

  • John Nelson, Ph.D., General Electric Global Research, Niskayuna, N.Y.,$900,000 (2 years),"Closed Complex Single Molecule Sequencing"

This team will use existing enzyme and dye-tagged nucleotide resources, the building block of DNA, in a novel way that will simplify the fundamental, front-end chemistry of massively parallel sequencing-by-synthesis. This method uses the natural catalytic cycle of DNA polymerase to capture just a single DNA base on an immobilized primer/template. A fluorescence scanner will be used to scan and identify hundreds of thousands of molecules at once. Then the cycle will be repeated. Thi
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Source:NIH/National Human Genome Research Institute


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