Navigation Links
Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

r proteins that are frequently mutated in human cancer," said Dr. David Solit, the study's first author and a medical oncologist at Memorial Sloan-Kettering who is also a member of Dr. Rosen's laboratory. This project, an outgrowth of the Human Genome Project, called the Cancer Genome Project, has the goal of identifying the causative mutations that cause human cancers.

"This represents what we believe will be the first of a series of new drugs that specifically target cancer cells that contain mutations identified by the Cancer Genome sequencing effort," said Dr. Solit. "The hope is that these new targeted therapies will be more effective and less toxic than traditional chemotherapies."

The study's other researchers were Christine A. Pratilas, Ayana Sawai, Andrea Basso, Qing Ye, Jose M. Lobo, and Yuhong She, all of Memorial Sloan-Kettering; Drs. Levi A.Galloway, Gad Getz, Todd R. Golub, and William R. Sellers of Dana-Farber Cancer Institute and Broad Institute of MIT and Harvard; Dr. Iman Osman of New York University Medical College; and Dr. Judith Sebolt-Leopold of Pfizer Global Research and Development.


'"/>

Source:Memorial Sloan-Kettering Cancer Center


Page: 1 2

Related biology news :

1. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
2. Biomarkers isolated from saliva successfully predict oral and breast cancer
3. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
4. Ocean climate predicts elk population in Canadian Rockies
5. Understanding biases in epidemic models important when making public health predictions
6. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
7. UNC computer, marine scientists collaborate to predict flow of toxic waters from Katrina
8. Rensselaer researchers develop approach that predicts protein separation behavior
9. Researchers predict infinite genomes
10. Modification of program enables prediction of gene transcription
11. Computers close in on protein structure prediction
Post Your Comments:
(Date:1/22/2015)... TORONTO , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the ... announced the launch of its new website design. ... in its infancy", says Peter O,Neill , founder and ... ever, the industry needs involvement from the key players on ...
(Date:1/22/2015)... N.C. , Jan. 16, 2015  A man-made form ... memory and other mental capabilities in adults with mild ... pilot study led by researchers at Wake Forest Baptist ... adults diagnosed with amnesic mild cognitive impairment (MCI) or ...
(Date:1/22/2015)... , Europe,s most ... Patent Office to present a video retrospective of the most exciting ... Christofer Toumazou and Sophie Wilson   ... the Award   Starting on 22 January 2015 on   ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... you ever wondered how the myriad insect forms—beetles, flies, ... , Insects make up 75% of all species known. ... result of a combination of one or more factors: ... speciation, an ability to adapt to new environments and ...
... leads, no person has managed to live much longer than ... may have extended the average human life span, it is ... of aging lays the blame on the accumulation of damage ... produced by the metabolic activity of mitochondria. , This damage ...
... A gene thought to influence perception and susceptibility to ... than in other primates, and this difference coincides with ... University Bloomington and three other academic institutions. Their report ... Science Biology. , The gene encodes prodynorphin, an ...
Cached Biology News:Adult stem cells aid recovery in animal model of cerebral palsy 2Navigating the brain for sense of direction as paradigm for higher cognitive functions 2'Perception' gene tracked humanity's evolution, scientists say 2'Perception' gene tracked humanity's evolution, scientists say 3
(Date:1/22/2015)... (PRWEB) January 22, 2015 Pipette.com has ... to their comprehensive portfolio of Eppendorf products. , ... to purchase a Centrifuge 5424/5424 R and receive the ... either Eppendorf Research plus or Eppendorf Reference 2 ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Controlled Substance ... Alliance, which helps companies check the legal requirements around ... expand to China. , As their international operations ... globally adopting software solutions built as a result of ...
(Date:1/22/2015)... NEW BRUNSWICK , Nueva Jersey , 22 ... Award for Biomedical Research abre hoy su llamada ... las personas cuya investigación científica ha hecho, o tiene ... de la salud humana. Las nominaciones se aceptarán hasta ...
(Date:1/22/2015)...   GenoSpace , a precision medicine software company that has ... use of genomic, imaging and other biomedical data in research ... Munson , CEO of Aspera, an IBM Company, to its ... http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased to welcome ...
Breaking Biology Technology:Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2Global Compliance Service for Controlled Substances to Expand to China 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2
... , , ... Formation of new blood vessels is fundamental to the development of ... and cell signaling research studies. Blood vessel development is a significant event in ... retinopathy and macular degeneration. , Traditional animal ...
... Z. Yang, Varian, Inc. , ... Bisphenol A (BPA) is a primary raw material used ... plastic. 4-Nonylphenol (4-NP) is a degradation product of alkylphenol ethoxylate detergents ... widely used as an additive in plastics that are used for ...
... and Jeffrey J. , Comerford#, Ph.D , ... Monash University, , Clayton campus, , ... , Varian Australia, , ... Victoria 3170, Australia , E-mail: fluorescence@varianinc.com , ...
Cached Biology Technology:An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis 2An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis 3An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis 4Analysis of Phenolic Estrogen Mimics in River Water by Negative Ion Electrospray LC/MS/MS 2Minimizing Photobleaching of Blue Fluorescent Protein (BFP) using , the Varian Cary Eclipse Fluorescence Spectrophotometer 2Minimizing Photobleaching of Blue Fluorescent Protein (BFP) using , the Varian Cary Eclipse Fluorescence Spectrophotometer 3Minimizing Photobleaching of Blue Fluorescent Protein (BFP) using , the Varian Cary Eclipse Fluorescence Spectrophotometer 4
... The mycobacteria in ... cells to the injection site which enhances ... Freund's Adjuvant is used for the initial ... the subsequent boosts. Antigens (preferably in saline) ...
The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma....
2,4-Dinitrophenyl hapten is conjugated to Keyhole Limpet (KLH) protein through lysine....
Alexa Fluor 350/488/594 Filter Set (Semrock Brightline) *mounted* *Zeiss Axio AF...
Biology Products: