Navigation Links
Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

r proteins that are frequently mutated in human cancer," said Dr. David Solit, the study's first author and a medical oncologist at Memorial Sloan-Kettering who is also a member of Dr. Rosen's laboratory. This project, an outgrowth of the Human Genome Project, called the Cancer Genome Project, has the goal of identifying the causative mutations that cause human cancers.

"This represents what we believe will be the first of a series of new drugs that specifically target cancer cells that contain mutations identified by the Cancer Genome sequencing effort," said Dr. Solit. "The hope is that these new targeted therapies will be more effective and less toxic than traditional chemotherapies."

The study's other researchers were Christine A. Pratilas, Ayana Sawai, Andrea Basso, Qing Ye, Jose M. Lobo, and Yuhong She, all of Memorial Sloan-Kettering; Drs. Levi A.Galloway, Gad Getz, Todd R. Golub, and William R. Sellers of Dana-Farber Cancer Institute and Broad Institute of MIT and Harvard; Dr. Iman Osman of New York University Medical College; and Dr. Judith Sebolt-Leopold of Pfizer Global Research and Development.


'"/>

Source:Memorial Sloan-Kettering Cancer Center


Page: 1 2

Related biology news :

1. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
2. Biomarkers isolated from saliva successfully predict oral and breast cancer
3. Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia
4. Ocean climate predicts elk population in Canadian Rockies
5. Understanding biases in epidemic models important when making public health predictions
6. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
7. UNC computer, marine scientists collaborate to predict flow of toxic waters from Katrina
8. Rensselaer researchers develop approach that predicts protein separation behavior
9. Researchers predict infinite genomes
10. Modification of program enables prediction of gene transcription
11. Computers close in on protein structure prediction
Post Your Comments:
(Date:5/23/2013)... Publishing in Neuron , the team reveal the ... in work funded by the Wellcome Trust and BBSRC. ... external stimuli we improve our perceptual abilities. While these ... they can also affect the fidelity of that response. ... Visual Neuroscience explains: "When you communicate with others, you ...
(Date:5/22/2013)... working to improve durability in fuel cell powered ... have discovered links between electrode degradation processes and ... the effects of electrode degradation stressors in the ... lifetime. , The findings of the study, led ... latest in a long-term study at Burnaby-based Ballard ...
(Date:5/22/2013)... approach to genetic engineering drastically reduces the time ... bacteria, the workhorses of biotechnology, scientists are reporting. ... , the method paves the way for more ... environmental cleanup and other activities. , Keith Shearwin ... piece of the genetic material DNA into a ...
Breaking Biology News(10 mins):Tests lead to doubling of fuel cell life 2
... According to modern biology textbooks, a single genetic mutation is ... cells must accumulate a series of mutations that work together ... researchers have shown that distinct cancer-causing mutations in neighboring cells ... Cancer biologists have long known ...
... people have attempted to understand the natural environment. We ... phenomena. Yet despite our persistence over thousands of years, ... understand core processes such as photosynthesis, we do not have ... their photosynthetic capacity. Specific leaf area, or ...
... for the Wildlife Conservation Society have discovered for the ... warblerdubbed in 2007 as "the world,s least known bird ... Pamir Mountains of north-eastern Afghanistan. Using a ... and the first known audio recording of the species, ...
Cached Biology News:Mutations in different cells cooperate to set the stage for cancer 2Mutations in different cells cooperate to set the stage for cancer 3Seeing the forest through the trees and seeing the trees through the leaves 2Wildlife Conservation Society finds 'world's least known bird' breeding in Afghanistan 2Wildlife Conservation Society finds 'world's least known bird' breeding in Afghanistan 3
(Date:5/23/2013)... Patheon Inc ., a leading provider of contract ... will host a complimentary webinar on “Cleaning Validation: Science, ... 4, 2013 at 11 a.m. Eastern Standard Time. ... regulations for cleaning validation. Many companies have incorporated ... evaluation of risk. Some companies have chosen to ...
(Date:5/23/2013)... MARINO, Calif. , May 23, 2013 /PRNewswire/ ... today a strategic alliance with DAK Renewable Research ... the corn oil yield. VG Energy is a ... (OTC Pink: VGLS). VG Energy,s exclusively ... to increase the oil yield in plants, possessing ...
(Date:5/23/2013)... Ill. , May 23, 2013 Z ... providing value-added ingredients to a variety of industries, announced ... in a panel discussion at this year,s National Restaurant ... 20-21, 2013, on behalf of the Research Chefs Association.  ... for Restaurants: The Good, the Bad and the Ugly," ...
(Date:5/23/2013)... During the conduct of research involving ... principles of good clinical practice (GCP) and human ... Lim, Fellow, Clinical Development at Novartis Pharmaceuticals, will ... the International Conference on Harmonization (ICH) Guideline for ... the conduction of clinical trials ,     Apply ...
Breaking Biology Technology:Patheon to Present on “Cleaning Validation: Science, Risk and Novel Approaches to Testing” 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 3Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 2Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 3Adhering to Good Clinical Practice, New Webinar Hosted by Xtalks 2
... 13 Proteon,Therapeutics, Inc. ( http://www.proteontherapeutics.com ), announced ... the European Patent Office. The patent,(No. 1220830) covers ... as elastases for,dilating arteries and veins in humans. ... in June and December of 2006. Proteon Therapeutics,owns ...
... has received its second Frost & Sullivan Technology Award ... the Frost & Sullivan Awards Banquet,Signalife was awarded the ... Monitoring. Signalife,s Chief Executive Officer, Dr.,Lowell Harmison, and its ... accept the award., Signalife, Inc. is in a ...
... Advancing Lead Candidate HspE7 into Phase 2 Clinical Trial in ... ... 13 Nventa Biopharmaceuticals,Corporation announced today financial results for the year ended ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080303/LAM023LOGO ), During 2007, the Company achieved ...
Cached Biology Technology:Proteon Therapeutics Receives European Patent Covering New Method of Dilating Arteries and Veins 2Signalife Wins Second Frost & Sullivan Technology Award 2Signalife Wins Second Frost & Sullivan Technology Award 3Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 2Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 3Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 4Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 5Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 6Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results 7