Navigation Links
Mutation in clams protects against paralytic shellfish poisoning but raises human health risk

Just like people, clams can be affected by the toxins that cause paralytic shellfish poisoning (PSP), but scientists have now identified a mutation in clams that gives some protection. PSP toxins interfere with nerve function, and the mutation, which changes a single amino acid in a sodium channel, makes nerves less sensitive to those toxins.

The discovery is reported in the April 7 issue of the journal Nature. The authors suggest that it has wide ranging implications for the evolution of shellfish in the presence of toxic algae and increases the risk of PSP to people who eat clams by enabling contaminated clams to survive in the presence of toxins.

The report, "Sodium channel mutation leading to saxitoxin resistance in clams increases risk of PSP," was written by a team of scientists, including Laurie Connell of the University of Maine School of Marine Sciences. It describes differences in the responses of two soft shell clam populations -- one in the Bay of Fundy and the other in the Lawrencetown estuary in Nova Scotia -- to saxitoxin as well as tetrodotoxin, a powerful toxin derived from the puffer fish.

The lead author is V. Monica Bricelj of the Institute for Marine Biosciences in Halifax, Nova Scotia, and in addition to Connell, co-authors are Keiichi Konoki, Todd Scheuer, and William A. Catterall of the University of Washington; Scott P. MacQuarrie of the Institute for Marine Biosciences; and Vera L. Trainer of the National Oceanic and Atmospheric Administration in Seattle.

"Since the 1960s, it's been known that different species of shellfish have different resistance to PSP toxins," says Connell. "This is the first time the source of that resistance has been shown. We now have a marker that can be used to determine if clams have this mutation. It's easy to use and could help reduce the time of clam flat closures (related to red tide)."

Betty Twarog, a neurophysiologist who works at UMaine's Darling Marine Center in Walp
'"/>

Source:University of Maine


Page: 1 2

Related biology news :

1. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
2. Mutation in blood stem cells provides clues to cancer development
3. Mutation improves memory, may lead to memory-enhancing pill
4. RNA found in the cellular centrosome of surf clams
5. Bound for destruction: Ubiquitination protects against improper Notch signaling
6. Experiments provide proof of how traveling in groups protects insects
7. Experiments provide proof of how traveling in groups protects insects
8. Substance protects resilient staph bacteria
9. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
10. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
11. Excess liver gene protects against high-fat diet
Post Your Comments:
(Date:7/31/2014)... biomass burning burning forests to create agricultural ... agriculture and wildfires figures into both climate ... release of a new study by Stanford University ... the degree of that contribution had never been ... paper published July 30 in the Journal ...
(Date:7/31/2014)... State University researchers have completed a 20-year study ... Hills prairie at different times of the year. ... late spring time frame has no measurable negative ... have multiple benefits. , The study was conducted ... Prairie Biological Station fire chief, and Joseph Craine, ...
(Date:7/31/2014)... Neb., July 31, 2014 -- Do people make a ... mothers raise them that way? Is it a matter ... Nebraska-Lincoln and a colleague from Rice University say that ... some people lean left while others lean right. , ... and deep-seated psychology are at the core of political ...
Breaking Biology News(10 mins):Stanford professor finds that wildfires and other burns play bigger role in climate change 2Stanford professor finds that wildfires and other burns play bigger role in climate change 3Stanford professor finds that wildfires and other burns play bigger role in climate change 4Study finds benefits to burning Flint Hills prairie in fall and winter 2Study finds benefits to burning Flint Hills prairie in fall and winter 3Scientists find growing consensus: Political attitudes derive from body and mind 2
... research team has taken a major step forward in understanding ... immune response by combining nanotechnology and cell biology. T cells ... response to infection. Christopher Cairo and his team ... cell response is switched on. Cairo looked at the molecule ...
... of this campus activity is divided into three sessions: ... a patient,s perspective and embryology and ethics related to ... genetic counselors, molecular biologists, cytogeneticists, physicians, nurses, embryologists, patient ... find more information on this event here: http://www.eshre.eu/page.aspx/905 ...
... a molecular-scale version of ice fishing, a team of ... Technology (NIST) have developed methods to measure accurately the ... membranes. The "molecular rulers" they describe in a recent ... nanoporeswhose diameters on average are nearly 10,000 times smaller ...
Cached Biology News:U Alberta-led team studies T cell activation with nanoparticles 2Lollipops and ice fishing: Molecular rulers used to probe nanopores 2
(Date:8/1/2014)... August 01, 2014 Once a decision ... cost? This webinar will discuss how to define your ... Join speakers Bob Allen, Senior Director of Facilities Integration ... Engineering at Fluor Industrial Services, and special guest Carrier ... Planning at Amgen, as they provide an examination of ...
(Date:8/1/2014)... -- Cambrex Corporation (NYSE: CBM ) reports results ... Highlights , Second quarter sales increased 59% ... last year. , Second quarter EBITDA increased 86% to ... last year (see table at the end of this release). ... impact of foreign currency, to between 13% and 16% over ...
(Date:8/1/2014)... ON (PRWEB) August 01, 2014 ... has led to a better understanding embryonic development. ... and reorganize into structurally and functionally distinct tissues ... physical defects. Prof. Todd McDevitt, Melissa Kinney, ... biophysical signals interact with biochemical cues to control ...
(Date:7/31/2014)... August 01, 2014 “2014 ... Polyurethane Resin Industry” is a professional and ... The report introduces Polyurethane Resin basic information, ... chain structure and industry overview. This research ... domestic market as well as global industry ...
Breaking Biology Technology:Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16Study Links Biomechanics and Gene Expression in Stem Cells 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 2Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 3Polyurethane Resin Industry & Thermoplastic Polyurethane Market (China, Global) Analysis Now at DeepResearchReports.com 4
... (Nasdaq: TARG ) today announced the pricing of ... stock at a price,to the public of $10.00 per ... Targanta has granted to the underwriters a 30-day option ... stock at the initial,offering price, less underwriting discounts and ...
... (NSH), a,leading owner and operator of surgical hospitals ... majority stake in Sterling Ridge Surgery,Center, a freestanding ... NSH acquired its share of the fully ... intends to convert the facility,into a surgical hospital ...
... No Water, Produces Pure Glycerin, CHICAGO and ... biodiesel refining and distribution company, announced today,that it ... a novel solid catalyst that converts low-grade fats ... be located in Seymour,Ind., eliminates the need for ...
Cached Biology Technology:Targanta Therapeutics Announces Pricing of its Initial Public Offering 2National Surgical Hospitals Acquires Majority Share of Houston-Area Surgery Center 2New Benefuel Refinery Targets Key Flaws in Biodiesel Production 2New Benefuel Refinery Targets Key Flaws in Biodiesel Production 3
UltraMount is formulated for coverslipping sections stained with alcohol soluble chromogens, such as Fast-Red or AEC. No heating is required prior to use. Coverslips may be removed by soaking in wate...
Agarose, Biotechnology grade, 500g...
AM100 is an aqueous-based, permanent mounting media designed for use with alkaline phosphatase and immunoperoxidase stained tissue sections....
... c-Jun proto-oncogene was first identified as the cellular ... Jun B and Jun D have been shown ... C-terminal regions, which are involved in dimerization and ... involved in transcriptional activation, diverge. ...
Biology Products: