Navigation Links
Mutation in blood stem cells provides clues to cancer development

that cancers use, subverting normal processes and using them for the wrong purpose. The discovery of this mutation means we can look toward interrupting these pathways, systematically, without wiping out the patient's normal blood cells."

PV is diagnosed in approximately 10,000 to 15,000 people in the United States per year, but the disease has a high prevalence, meaning that people suffer from the disease over a long period of time. The major clinical consequence of PV is the development of thrombosis, in part related to the increased viscosity of the blood. The disorder can also lead to scarring of the bone marrow and acute leukemia. Currently, patients are treated by bleeding them (phlebotomy) or administering low-dose chemotherapy. Co-author Jason Gotlib, M.D., M.S., assistant professor of medicine at the Stanford University School of Medicine said, "We now appreciate that the challenge in fighting certain forms of blood cancer is partly due to a reservoir of leukemic stem cells that are resistant to current therapies. The discovery of the JAK2 mutation in stem cells in patients with PV is an important first step in developing treatments which target the earliest population of cells which propagate the disease."

The research also provides more insight into why some patients develop leukemia or other malignancies, while others don't, by identifying determinant cancer genes and the signaling pathways leading to the disease.

"It will tell us more about cancer and how cancer progresses," Jamieson added. "Usually, cancer isn't just there all of a sudden overnight; it develops by a series of mutations."

The next steps are to see how other stem cell functions on this pathway ?such as self-renewal, survival and proliferation, are affected ?and to duplicate this in-vitro research in mouse models. Working with specific inhibitors developed by local pharmaceutical companies, the UCSD and Stanford researchers plan to conduct clinica
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
2. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
3. Mutation improves memory, may lead to memory-enhancing pill
4. White blood cell waste disposal system plays critical regulatory role
5. Epstein-Barr virus protein crucial to its role in blood cancers
6. New insight into regulation of blood stem cells
7. Nano-bumps could help repair clogged blood vessels
8. First technology to remove prions that cause vCJD from blood launched
9. Breakthrough isolating embryo-quality stem cells from blood
10. Thai spice helps cut blood sugar swings
11. Study shows humans have ability to track odors, much like bloodhounds
Post Your Comments:
(Date:12/16/2009)... -- IgeaCare Solutions Inc. is pleased to announce ... communications company previously operating as IgeaCare Systems Inc. ... forward under new leadership and funding. ,, IgeaCare ... the position of Chief Executive Officer. Under his ... a superior servicing and support model; fast and ...
(Date:12/15/2009)... 15 The 2009 Frost & ... is presented to Sagem Securite (Safran Group) ... The award recognises the company,s expertise in ... in offering novel, value-added products to end ... ) ,, "Sagem Securite has been involved ...
(Date:12/15/2009)... Inc. GenWay Clinical Laboratory, San Diego, California, has ... American Pathologists (CAP), based on results of a ... director was advised of this national recognition and ... provided." GenWay Biotech Inc. GenWay Clinical Laboratory is ... The CAP Laboratory Accreditation Program, begun in the ...
Breaking Biology News(10 mins):IgeaCare Solutions Inc. Emerges Under New Leadership and Funding 2Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 2Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 3Frost & Sullivan Recognises Sagem Securite for its Innovative Automated Border Control Systems 4MediciGlobal Achieves Record Number of Awards 51914 1MediciGlobal Achieves Record Number of Awards 51914 2Apieron Inc Files Infringement Complaint Against Aerocrine AB Aerocrine AG and Mr Magnus Pelles 51909 1St Alexius Medical Center Named to Americas Best Hospitals Rankings 51905 1St Alexius Medical Center Named to Americas Best Hospitals Rankings 51905 2
... and then moving into mice and humans, researchers at VIB and ... cancer in all three organisms. Reciprocally, switching off the gene ... cancer. The authors show there is a good chance that the ... their findings in two papers in the leading online open access ...
... method for identifying levels of exposure to environmental arsenic ... naturally in the environment and people can be exposed ... water, food, dust or soil. The risk of exposure ... the natural geology and historic mining activities have led ...
... 22, 2009--Researchers at the Dana-Farber Cancer Institute (Dana-Farber), ... Centers for Disease Control and Prevention (CDC) have ... that neutralize an unprecedented range of influenza A ... pandemic influenza viruses, and some seasonal influenza viruses. ...
Other Biology News:Suppressing cancer with a master control gene 2Arsenic and old toenails 2Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses 2Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses 3
(Date:12/16/2009)... by scientists at the University of East Anglia (UEA) ... domestic or agricultural waste to generate clean electricity. , ... of the National Academy of Sciences (PNAS), the ... by which some bacteria survive by ,breathing rocks,. , ... development of new microbe-based technologies such as fuel cells, ...
(Date:12/16/2009)... Martek Biosciences Corporation (Nasdaq: MATK ) today announced ... year ended October 31, 2009. Revenues for the fourth ... in the fourth quarter of fiscal 2008. Net income ... the fourth quarter of fiscal 2009, a 5% increase ... in last year,s fourth quarter. The fourth quarter ...
(Date:12/16/2009)... Blood America, Inc. (OTC Bulletin Board: CBAI), the ... http://www.cordblood-america.com ) focused on bringing the life ... policy, to families nationwide and internationally, said today ... total of $1.4 million so far in the ... for the year now tops $10 million. ,, ...
(Date:12/16/2009)... DIEGO, Dec. 16 Sequenom, Inc. (Nasdaq: ... Dr. Kenneth Buechler and Mr. David Pendarvis to ... http://www.newscom.com/cgi-bin/prnh/20040415/SQNMLOGO ) ,, Kenneth F. Buechler, Ph.D., ... Biosite Incorporated. From 1988 to 1994, Dr. Buechler ... Biosite, Dr. Buechler was a senior research scientist ...
Breaking Biology Technology:'Rock-breathing' bacteria could generate electricity and clean up oil spills 2Martek Announces Fourth Quarter and FY 2009 Financial Results 2Martek Announces Fourth Quarter and FY 2009 Financial Results 3Martek Announces Fourth Quarter and FY 2009 Financial Results 4Martek Announces Fourth Quarter and FY 2009 Financial Results 5Martek Announces Fourth Quarter and FY 2009 Financial Results 6Martek Announces Fourth Quarter and FY 2009 Financial Results 7Martek Announces Fourth Quarter and FY 2009 Financial Results 8Martek Announces Fourth Quarter and FY 2009 Financial Results 9Martek Announces Fourth Quarter and FY 2009 Financial Results 10Martek Announces Fourth Quarter and FY 2009 Financial Results 11Martek Announces Fourth Quarter and FY 2009 Financial Results 12Martek Announces Fourth Quarter and FY 2009 Financial Results 13Martek Announces Fourth Quarter and FY 2009 Financial Results 14Cord Blood America Says 2009 Debt Reduction Tops $10 Million 2Cord Blood America Says 2009 Debt Reduction Tops $10 Million 3Sequenom Appoints Two New Board Members 2Sequenom Appoints Two New Board Members 3
... MILWAUKEE, WI - Representatives of the Medical College of ... were featured on a Milwaukee business television show, Avante's ... September 27, on WISN. , ,Dr. Jeffrey Smith, clinical ... Wisconsin Medical School was joined by Mike Klein, ...
... from his position as director of the nonpartisan ... the reasons for his ouster. , ,And while Senate ... of an audit of the bureaus performance as the ... John Gard (R-Peshtigo) said the move was simple politics. ...
... Though results for third-quarter publicly traded biotech stocks continue ... be slowing down (or else the rest of the market ... to lead with year-to-date sizzling growth of 42 percent versus ... Jones Industrials respectable growth of 12 percent. The Amex Biotech ...
Other Biology Technology:The Information Age of Healthcare - Leaders featured on local new economy show 2The Information Age of Healthcare - Leaders featured on local new economy show 3Wahl Mute on Firing from Legislative IT Bureau -- but politics could be to blame 2Midwest Public-Sector Biotech Continues to Sizzle 2
... The Fujifilm Life Science LAS-3000 ... technology with a simplified user interface, ... a wide range of modularities. The ... applications, and the perfect standard system ...
... Life Science LAS-3000mini is a compact ... chemiluminescence applications, and the perfect standard ... 's LAS-3000 provides significantly improved system ... Glowell calibration standards validate that Fujis ...
... assays. The TUNEL-based assay kit provides complete ... for convenient detection of DNA fragmentation in ... offers an one-step labeling of apoptotic cells. ... hallmark of apoptosis in mammalian cells. MBLs ...
SDS-OutT Precipitation Reagent...
Biology Products: