Navigation Links
Mutation improves memory, may lead to memory-enhancing pill

mice were trained to swim to a hidden platform. After several days of training, the altered mice were able to find the platform significantly faster than normal mice could, they reported.

"For example, if a person were reading a page of a textbook, it might take several times to memorize it," Costa-Mattioli said. "A human equivalent of these mice would get the information right away."

The mutant mice also performed better than normal mice in a "fear-conditioning" test. In that test, animals are put into a cage followed by a mild foot shock or are exposed to a tone paired with a foot shock. Their memory for the earlier bad experience is determined based on how much they freeze in response to the "scary" place or sound 24 hr later.

Importantly, the researchers also showed that treatment of animals with a small molecule that increases eIF2a's phosphorylation led to poorer performance on the memory tests.

“These data strengthen the idea that eIF2a phosphorylation is a key, bidirectional point of memory control,?with the ability to turn long-term memory formation on and off, Costa-Mattioli said.

"Taken together, these data strongly support the notion that, under physiological conditions, a decrease in eIF2a phosphorylation constitutes a critical step for the activation of gene expression that leads to the long-term synaptic changes required for memory formation," the researchers concluded. "These findings also raise the interesting possibility that regulators of translation could serve as therapeutic targets for the improvement of memory, for instance in human disorders associated with memory loss."
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
2. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
3. Mutation in blood stem cells provides clues to cancer development
4. Product improves peptide identification for proteomics research
5. Stem cell treatment improves mobility after spinal cord injury
6. Combination therapy improves AIDS-related lymphoma outcome
7. One fish, two fish: New MIT sensor improves fish counts
8. Man-made heart tissue improves cardiac performance
9. Viagra improves high altitude exercise performance up to 45% for some
10. Quitting smoking improves lung function considerably
11. Melatonin improves mood in winter depression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mutation improves memory may lead memory enhancing pill

(Date:8/27/2014)... the Volunteer Wildfire Services of South Africa as "Cape ... residents in certain parts of the province on Monday ... high veld fire danger rating is expected in the ... Kei and Mnquma area. Strong winds often occurred ... bring lightning strikes and subsequent fire and the wind ...
(Date:8/27/2014)... number of consumers are willing to pay a premium ... whether they,re getting what the label claims is another ... devising a new way to make sure farms are ... ACS, Journal of Agricultural and Food Chemistry , ... the Bavarian Health and Food Safety Authority and the ...
(Date:8/27/2014)... of studies have shown that excessive iron ... Parkinson,s disease. Previous studies from Chunyan Guo ... China have shown that baicalin prevented iron ... metal transporter 1 expression, and increased ferroportin ... rotenone-induced Parkinson,s disease rats. However, the relationship ...
Breaking Biology News(10 mins):
... night blindness, an inherited condition that affects one,s ability to ... mutation in a calcium channel protein that shuttles calcium into ... University School of Medicine have teased apart the molecular mechanism ... cells control calcium levels. The discovery, published in the Feb. ...
... a serious toll on plants and animals alike. When cells ... and, without water as a medium, chemicals and enzymes inside ... named "resurrection fern" ( Polypodium polypodioides ), can survive extreme ... their water content. How do the cells in these desiccation-tolerant ...
... March 18, 2010. How did China and Australia develop ... Europe? A panel of U.S. experts will try to ... a workshop at the National Science Foundation (NSF) in Arlington, ... the National Science Foundation and other Federal agencies, the World ...
Cached Biology News:Understanding night blindness and calcium 2Bringing dehydrated plants 'back to life' 2Bringing dehydrated plants 'back to life' 3Workshop on R&D for rapid vaccine development and production in Asia/Australia 2
(Date:8/27/2014)... Aug. 27, 2014 Reportlinker.com announces ... available in its catalogue: Global ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About ... that are readily decomposed by the action ... non-degradable packaging in terms of raw materials, ...
(Date:8/27/2014)... 27, 2014 Research and Markets ... Lactic Acid  (Biodegradable Polymer, Food & Beverage, Personal ... to 2019" report to their offering. ... with an asymmetrical carbon atom. The main applications ... food and beverage, personal care product, and pharmaceutical ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com ... The Graphene Opportunity - A Rational View ... Graphene The New Nanotech? A similar amount ... of applications ranging from microelectronics to water treatment, ... announced the availability of the Graphene Opportunity Report, ...
(Date:8/27/2014)... JUNCTION, N.J. , Aug. 27, 2014 ... innovative drug delivery technologies, today announced that it has ... Jersey Business & Industry Association,s 2014 Awards for ... were selected by an independent panel of judges from ... company volunteers. Award winners will be honored at a ...
Breaking Biology Technology:Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4Tris Pharma Selected as an award winner in the New Jersey Business & Industry Association's 2014 Awards for Excellence 2
... step closer to creating a micro-aircraft that flies with the ... aerodynamic secrets of insect flight. Dr John Young, from ... and a team of animal flight researchers from Oxford University,s ... locusts in action in a wind tunnel, capturing how the ...
... , , SAN ... ("STI"), a privately-held and development-stage biopharmaceutical company with a ... human therapeutic antibodies for the treatment of a variety ... of QuikByte Software, Inc. (OTC Bulletin Board: QBSW), a ...
... , , , , ... independent, nonprofit research and development institute, announced today that John J. ... September 1, 2009. Young will become the SRI Board,s tenth ... the business community. , , "Throughout his career, ...
Cached Biology Technology:Secrets of insect flight revealed 2Sorrento Therapeutics, Inc. and QuikByte Software, Inc. Complete Merger 2Sorrento Therapeutics, Inc. and QuikByte Software, Inc. Complete Merger 3Sorrento Therapeutics, Inc. and QuikByte Software, Inc. Complete Merger 4John J. Young, Jr. Joins SRI Board of Directors 2John J. Young, Jr. Joins SRI Board of Directors 3
... This goat anti-rabbit IgG FITC ... antibody' for immunofluorescent staining on tissues ... antibody is generated in rabbits. It ... controls, such as omitting the primary ...
1000X solution used for inducing CopyControl™ based vectors to high copy numbers...
Request Info...
HAS1 (C-14)...
Biology Products: