Navigation Links
Mutation improves memory, may lead to memory-enhancing pill

The second component, which follows strong or repetitive training, activates mechanisms that stabilize the memory and nerve connections, resulting in long-term memory, lasting days, weeks, or years.

"Quite different molecular machineries, widely conserved from sea slugs to rodents, are thought to underlie these two components. While modifications of pre-existing proteins are sufficient for the transient changes, new gene expression is required for those that are sustained," the researchers said, emphasizing that a gene's expression depends on both its transcription into messenger RNA and the translation of that messenger RNA into functional proteins.

Sonenberg and Costa-Mattioli earlier found the first genetic evidence that control over protein synthesis plays an important role in the formation of lasting memories.

"Most of the focus on gene control is at the level of transcription," Sonenberg said. "In contrast, here there is control at the level of translation—in making protein from messenger RNA, a less appreciated mode of regulation."

When the regulatory protein eIF2a is chemically modified with the addition of a phosphate to one of its amino acids, it switches on the protein synthesis of another factor that halts production of genes required for the long-term storage of memories. Sonenberg and his colleagues previously discovered that mice lacking the enzyme that performs the phosphorylation reaction have a superior ability to remember new things under certain training conditions.

“Those results led us to suspect that decreasing the phosphorylation of eIF2a enhanced memory storage,?Costa-Mattioli said.

In an effort to validate their earlier findings, the researchers have now generated mice carrying a version of eIF2a that cannot be phosphorylated. The mutant mice have lower levels of phosphorylated eIF2a and showed an improved talent for spatial learning in a water maze test.

In the test, the
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Mutation in clams protects against paralytic shellfish poisoning but raises human health risk
2. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
3. Mutation in blood stem cells provides clues to cancer development
4. Product improves peptide identification for proteomics research
5. Stem cell treatment improves mobility after spinal cord injury
6. Combination therapy improves AIDS-related lymphoma outcome
7. One fish, two fish: New MIT sensor improves fish counts
8. Man-made heart tissue improves cardiac performance
9. Viagra improves high altitude exercise performance up to 45% for some
10. Quitting smoking improves lung function considerably
11. Melatonin improves mood in winter depression
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mutation improves memory may lead memory enhancing pill

(Date:4/20/2015)... , April 20, 2015 Huntington Memorial ... Valley to implant a new miniaturized, wireless monitoring sensor ... is the first and only FDA-approved heart failure monitoring ... admissions when used by physicians to manage heart failure. ... that is implanted in the pulmonary artery (PA) during ...
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... 23, 2015, after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2
... of the Integrated Ocean Drilling Programs Nankai Trough ... the Kii Peninsula today. The expedition science party, ... Dec. 19, 2007, aboard the drilling vessel Chikyu, ... characteristics of the Nankai Trough fault zone. The ...
... for Maritime Systems (CMS) at Stevens Institute of Technology ... Agency for International Development (USAID) that is focused on ... through scientific collaboration. , The collaboration is based on ... for a variety of marine products. The main idea ...
... in German . , Anthropogenic forcing ... so that important components may tip into qualitatively different ... the National Academy of Sciences (PNAS) an international team ... long-term consequences on human and ecological systems. Society ...
Cached Biology News:Scientists obtain core samples from subsea fault system off Japan 2Tipping elements in the Earth's climate system 2Tipping elements in the Earth's climate system 3Tipping elements in the Earth's climate system 4
(Date:5/6/2015)... -- Northwest Biotherapeutics (NASDAQ: NWBO) ("NW Bio"), a U.S. biotechnology company ... announced that Linda Powers , NW Bio CEO, will present ... for solid tumor cancers and the Company,s multiple clinical programs ... , , , DATE: , , , Thursday, May ... , 12:15 PM EDT , , , , LINK: ...
(Date:5/6/2015)... Park Systems , world-leader in ... high vacuum AFM system in the market that meets ... manufacturing. Park NX-Hivac is ideal for academic and industrial ... highly doped semiconductor processing where more highly sophisticated failure ... vacuum scanning spreading resistance microscopy (SSRM) of Park NX-Hivac ...
(Date:5/6/2015)... Histogen, Inc., a regenerative medicine ... cells grown under simulated embryonic conditions, will present ... for melanoma during the 2015 Society of Investigative ... 2015 in Atlanta, GA. , Histogen has previously ... material with anti-oncologic properties, with potential benefit in ...
(Date:5/6/2015)... 2015 The Remedy Group , ... for the specialty pharmacy industry, will be exhibiting, presenting, ... Specialty Pharmacy Summit. The Summit will be held May ... and is the largest annual gathering for the specialty ... from pharmacy providers, pharma/biotech manufacturers, and payers, to learn ...
Breaking Biology Technology:NW Bio To Webcast, Live, at VirtualInvestorConferences.com On May 7 2NW Bio To Webcast, Live, at VirtualInvestorConferences.com On May 7 3Park Systems Introduces Park NX-Hivac, a High Vacuum SSRM AFM System for Optimal Results in Semiconductor Manufacturing Failure Analysis 2Park Systems Introduces Park NX-Hivac, a High Vacuum SSRM AFM System for Optimal Results in Semiconductor Manufacturing Failure Analysis 3Novel Immunomodulatory Treatment Induces Apoptosis in Melanoma 2The Remedy Group presenting at the 2015 Armada Specialty Pharmacy Summit: The Pitfalls to Growth and Maintaining the Patient Experience 2
... Feb. 28 As the leading distributor ... a business,partnership with Spectra Intelligence which allows ... market analyses through the,MarketResearch.com website., The ... world,easy access to complete product descriptions and ...
... Actavis Group, the,international generic pharmaceuticals company, has received ... & Drug,Administration. Distribution of the product will begin ... to Pfizer,s,Camptosar(R) will be available in 40 mg/2 ... is,used in the treatment of patients with metastatic ...
... Barring Importation of CryoCath,s Cryoablation System, SAN ... medical device company focused on the treatment of ... formal complaint with the,United States International Trade Commission ... unfair trade practices by infringing on,several CryoCor patents ...
Cached Biology Technology:MarketResearch.com Announces Distribution of Spectra Intelligence Research 2Actavis Receives Approval for Irinotecan Hydrochloride Injection; Extends US Portfolio with First Injectable Product 2CryoCor Requests International Trade Commission Investigation Into CryoCath for Patent Infringement 2CryoCor Requests International Trade Commission Investigation Into CryoCath for Patent Infringement 3
NAP-2 (5C7)...
IKKbeta/IKK-2 Polyclonal Antibody 100 ug affinity purified rabbit polyclonal antibody. Reacts with human. Tested in Western blotting....
golgi reassembly stacking protein 2, 55kDa...
1, 2 or 8 PreMixes are included as part of the FailSafe™ PCR System....
Biology Products: